Fcar (Fc alpha receptor) - Rat Genome Database

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Gene: Fcar (Fc alpha receptor) Rattus norvegicus
Analyze
Symbol: Fcar
Name: Fc alpha receptor (Ensembl:Fc fragment of IgA receptor)
RGD ID: 1303082
Description: Human ortholog(s) of this gene implicated in IgA glomerulonephritis; granulomatosis with polyangiitis; and renal fibrosis. Orthologous to human FCAR (Fc alpha receptor); PARTICIPATES IN phagocytosis pathway; Staphylococcus aureus infection pathway; INTERACTS WITH amphetamine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cd89; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; immunoglobulin alpha Fc receptor
RGD Orthologs
Human
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,669,119 - 78,703,223 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2169,626,458 - 69,660,558 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx174,985,346 - 75,019,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,549,652 - 83,583,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,707,876 - 76,741,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,230,392 - 73,263,462 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,230,390 - 73,264,302 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,285,444 - 75,318,514 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,976,542 - 69,022,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,474,424 - 67,508,554 (+)NCBICelera
RGSC_v3.1169,054,652 - 69,100,762 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. Berthelot L, etal., J Exp Med. 2012 Apr 9;209(4):793-806. doi: 10.1084/jem.20112005. Epub 2012 Mar 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. Kanamaru Y, etal., J Immunol. 2008 Feb 15;180(4):2669-78.
4. IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. Kelley JM, etal., Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20736-41. doi: 10.1073/pnas.1109227109. Epub 2011 Dec 6.
5. Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex. Maruoka T, etal., Immunogenetics 2004 Jan;55(10):712-6. Epub 2003 Nov 26.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Negative regulation of inflammatory responses by immunoglobulin A receptor (FcalphaRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis. Watanabe T, etal., Clin Exp Immunol. 2011 Nov;166(2):235-50. doi: 10.1111/j.1365-2249.2011.04452.x.
Additional References at PubMed
PMID:25339672  


Genomics

Comparative Map Data
Fcar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,669,119 - 78,703,223 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2169,626,458 - 69,660,558 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx174,985,346 - 75,019,443 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,549,652 - 83,583,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,707,876 - 76,741,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,230,392 - 73,263,462 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,230,390 - 73,264,302 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,285,444 - 75,318,514 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4168,976,542 - 69,022,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,474,424 - 67,508,554 (+)NCBICelera
RGSC_v3.1169,054,652 - 69,100,762 (-)NCBI
Cytogenetic Map1q12NCBI
FCAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,874,235 - 54,891,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,874,235 - 54,891,420 (+)Ensemblhg38GRCh38
GRCh371955,385,691 - 55,402,786 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,077,361 - 60,093,651 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341960,077,360 - 60,092,249NCBI
Celera1952,426,154 - 52,442,442 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,708,188 - 51,724,488 (+)NCBIHuRef
CHM1_11955,379,113 - 55,395,493 (+)NCBICHM1_1
T2T-CHM13v2.01957,968,550 - 57,985,728 (+)NCBIT2T-CHM13v2.0
FCAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,012,313 - 61,030,983 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,741,639 - 62,762,425 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,919,345 - 51,935,340 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,614,350 - 60,630,614 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,614,405 - 60,630,480 (+)EnsemblpanPan2panpan1.1
FCAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,709,675 - 102,720,680 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,773,321 - 102,784,329 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01103,376,217 - 103,387,212 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11102,995,899 - 103,006,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,700,005 - 102,711,007 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,472,232 - 103,483,230 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FCAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,074,996 - 59,084,788 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1659,074,979 - 59,084,798 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,998,651 - 54,008,044 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FCAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,498,332 - 47,512,629 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,498,497 - 47,514,417 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604532,031 - 48,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fcar
152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:201
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000029621
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 1 17 86 38 46 16 104 16 5 201 143 15 64 25 55 30 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000025080   ⟹   ENSRNOP00000025080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,616,601 - 69,622,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000029621   ⟹   ENSRNOP00000028910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,616,601 - 69,660,558 (-)Ensembl
Rnor_6.0 Ensembl173,230,392 - 73,264,302 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087826   ⟹   ENSRNOP00000069202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl173,230,390 - 73,263,466 (-)Ensembl
RefSeq Acc Id: NM_201992   ⟹   NP_973721
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,669,119 - 78,703,223 (-)NCBI
mRatBN7.2169,626,458 - 69,660,558 (-)NCBI
Rnor_6.0173,230,392 - 73,263,462 (-)NCBI
Rnor_5.0175,285,444 - 75,318,514 (+)NCBI
RGSC_v3.4168,976,542 - 69,022,651 (-)RGD
Celera167,474,424 - 67,508,554 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_973721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD08446 (Get FASTA)   NCBI Sequence Viewer  
  BAD08447 (Get FASTA)   NCBI Sequence Viewer  
  BAD08448 (Get FASTA)   NCBI Sequence Viewer  
  EDL75825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028910.5
  ENSRNOP00000100574.1
  ENSRNOP00000106283.1
RefSeq Acc Id: NP_973721   ⟸   NM_201992
- Peptide Label: precursor
- UniProtKB: A6KNK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069202   ⟸   ENSRNOT00000087826
Ensembl Acc Id: ENSRNOP00000028910   ⟸   ENSRNOT00000029621
Ensembl Acc Id: ENSRNOP00000025080   ⟸   ENSRNOT00000025080
Protein Domains
Immunoglobulin   Immunoglobulin-like beta-sandwich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRL6-F1-model_v2 AlphaFold D3ZRL6 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303082 AgrOrtholog
BioCyc Gene G2FUF-60830 BioCyc
Ensembl Genes ENSRNOG00000027855 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029621.8 UniProtKB/TrEMBL
  ENSRNOT00000147346.1 UniProtKB/TrEMBL
  ENSRNOT00000155612.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
NCBI Gene 365183 ENTREZGENE
PANTHER IMMUNOGLOBULIN ALPHA FC RECEPTOR UniProtKB/TrEMBL
  MHC CLASS I NK CELL RECEPTOR UniProtKB/TrEMBL
  NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1 UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
PhenoGen Fcar PhenoGen
RatGTEx ENSRNOG00000027855 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0ABK0L8L1_RAT UniProtKB/TrEMBL
  A0ABK0LWG4_RAT UniProtKB/TrEMBL
  A6KNK6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRL6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-11 Fcar  Fc alpha receptor  Fcar  Fc fragment of IgA receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-29 Fcar  Fc fragment of IgA receptor  Fcar  Fc fragment of IgA, receptor for  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-01 Fcar  Fc fragment of IgA, receptor for  Fcar  IgA Fc receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Fcar  IgA Fc receptor      Symbol and Name status set to provisional 70820 PROVISIONAL