Tomm40 (translocase of outer mitochondrial membrane 40) - Rat Genome Database

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Gene: Tomm40 (translocase of outer mitochondrial membrane 40) Rattus norvegicus
Analyze
Symbol: Tomm40
Name: translocase of outer mitochondrial membrane 40
RGD ID: 1303022
Description: Enables monoatomic cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; intermembrane space assembly pathway of mitochondrial protein import; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mitochondrial import receptor subunit TOM40 homolog; mitochondrial outer membrane protein of 38 kDa; OM38; outer membrane protein 38 kDa; TOM40; translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog; translocase of outer mitochondrial membrane 40 homolog (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,486,745 - 88,498,833 (-)NCBIGRCr8
mRatBN7.2179,358,781 - 79,370,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,754,076 - 84,765,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,305,430 - 93,316,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,509,183 - 86,520,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,617,749 - 80,630,253 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,883,227 - 81,895,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,008,895 - 79,020,420 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,087,005 - 79,098,531 (-)NCBI
Celera173,818,380 - 73,829,904 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glafenine  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
2. Bax inserts into the mitochondrial outer membrane by different mechanisms. Cartron PF, etal., FEBS Lett. 2008 Sep 3;582(20):3045-51. doi: 10.1016/j.febslet.2008.07.047. Epub 2008 Aug 5.
3. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM and Kowluru RA, Diabetes Metab Res Rev. 2013 Mar;29(3):204-13. doi: 10.1002/dmrr.2384.
12. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13. Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. Suzuki H, etal., J Biol Chem 2000 Dec 1;275(48):37930-6.
14. Membrane-embedded C-terminal segment of rat mitochondrial TOM40 constitutes protein-conducting pore with enriched beta-structure. Suzuki H, etal., J Biol Chem. 2004 Nov 26;279(48):50619-29. Epub 2004 Sep 3.
15. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
16. Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Yamase Y, etal., Biomed Rep. 2015 Jul;3(4):491-498. doi: 10.3892/br.2015.457. Epub 2015 Apr 29.
Additional References at PubMed
PMID:11745481   PMID:12198123   PMID:12931191   PMID:14651853   PMID:15136728   PMID:15644312   PMID:17437969   PMID:18614015   PMID:20107041   PMID:23376485   PMID:24746669   PMID:28376086  
PMID:30121780   PMID:30296408  


Genomics

Comparative Map Data
Tomm40
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,486,745 - 88,498,833 (-)NCBIGRCr8
mRatBN7.2179,358,781 - 79,370,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,754,076 - 84,765,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,305,430 - 93,316,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,509,183 - 86,520,735 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,617,749 - 80,630,253 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,883,227 - 81,895,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,008,895 - 79,020,420 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,087,005 - 79,098,531 (-)NCBI
Celera173,818,380 - 73,829,904 (-)NCBICelera
Cytogenetic Map1q21NCBI
TOMM40
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,891,254 - 44,903,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,890,569 - 44,903,689 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,394,511 - 45,406,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,086,334 - 50,098,783 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,086,333 - 50,098,775NCBI
Celera1942,198,820 - 42,211,268 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,824,784 - 41,837,732 (+)NCBIHuRef
CHM1_11945,397,251 - 45,409,700 (+)NCBICHM1_1
T2T-CHM13v2.01947,715,975 - 47,728,385 (+)NCBIT2T-CHM13v2.0
Tomm40
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,435,238 - 19,449,370 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,435,238 - 19,449,363 (-)EnsemblGRCm39 Ensembl
GRCm38719,701,313 - 19,715,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,701,313 - 19,715,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,286,662 - 20,300,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,859,840 - 18,873,778 (-)NCBIMGSCv36mm8
Celera717,107,398 - 17,121,516 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Tomm40
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,987,261 - 1,996,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,987,063 - 1,997,329 (+)NCBIChiLan1.0ChiLan1.0
TOMM40
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,050,714 - 51,065,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,922,618 - 52,935,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,839,025 - 41,851,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,445,268 - 50,457,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,444,475 - 50,457,729 (+)Ensemblpanpan1.1panPan2
TOMM40
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,530,233 - 110,541,049 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,530,597 - 110,541,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,011,176 - 110,021,984 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,060,001 - 111,070,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,060,005 - 111,071,097 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,734,654 - 110,745,459 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,370,126 - 110,380,934 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,238,917 - 111,249,729 (-)NCBIUU_Cfam_GSD_1.0
Tomm40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,152,860 - 17,162,972 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,500,244 - 1,510,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM40
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,359,595 - 51,369,908 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,359,948 - 51,369,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,257,121 - 47,266,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM40
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,363,060 - 38,375,098 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,363,176 - 38,375,218 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,932,848 - 17,945,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm40
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,740,549 - 1,751,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,740,450 - 1,751,066 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tomm40
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:63
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000025281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH141850  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,358,945 - 79,359,138 (+)MAPPERmRatBN7.2
Rnor_6.0180,617,914 - 80,618,106NCBIRnor6.0
Rnor_5.0181,883,392 - 81,883,584UniSTSRnor5.0
RGSC_v3.4179,008,655 - 79,008,847UniSTSRGSC3.4
Celera173,818,140 - 73,818,332UniSTS
RH 3.4 Map1819.8UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025281   ⟹   ENSRNOP00000025281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,358,786 - 79,370,915 (-)Ensembl
Rnor_6.0 Ensembl180,618,154 - 80,630,038 (-)Ensembl
RefSeq Acc Id: NM_212520   ⟹   NP_997685
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,486,745 - 88,498,833 (-)NCBI
mRatBN7.2179,358,781 - 79,370,870 (-)NCBI
Rnor_6.0180,618,154 - 80,630,038 (-)NCBI
Rnor_5.0181,883,227 - 81,895,703 (-)NCBI
RGSC_v3.4179,008,895 - 79,020,420 (-)RGD
Celera173,818,380 - 73,829,904 (-)RGD
Sequence:
RefSeq Acc Id: NP_997685   ⟸   NM_212520
- UniProtKB: G3V8F5 (UniProtKB/TrEMBL),   A6J8T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025281   ⟸   ENSRNOT00000025281

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q75Q40-F1-model_v2 AlphaFold Q75Q40 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689781
Promoter ID:EPDNEW_R305
Type:single initiation site
Name:Tomm40_1
Description:translocase of outer mitochondrial membrane 40
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,629,954 - 80,630,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303022 AgrOrtholog
BioCyc Gene G2FUF-60487 BioCyc
Ensembl Genes ENSRNOG00000018556 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025281.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Porin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:308416 UniProtKB/Swiss-Prot
NCBI Gene 308416 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10802 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Porin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tomm40 PhenoGen
RatGTEx ENSRNOG00000018556 RatGTEx
UniProt A6J8T5 ENTREZGENE, UniProtKB/TrEMBL
  A6J8T8_RAT UniProtKB/TrEMBL
  A6J8T9_RAT UniProtKB/TrEMBL
  A6J8U1_RAT UniProtKB/TrEMBL
  A6J8U3_RAT UniProtKB/TrEMBL
  G3V8F5 ENTREZGENE, UniProtKB/TrEMBL
  Q75Q40 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm40  translocase of outer mitochondrial membrane 40  Tomm40  translocase of outer mitochondrial membrane 40 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tomm40  translocase of outer mitochondrial membrane 40 homolog (yeast)    translocase of outer mitochondrial membrane 40  Name updated 1299863 APPROVED
2005-01-04 Tomm40  translocase of outer mitochondrial membrane 40  TOM40  translocase of outer mitochondrial membrane 40  Symbol updated 1299863 PROVISIONAL
2005-01-04   translocase of outer mitochondrial membrane 40  TOM40  TOM40 protein  Name updated 1299863 PROVISIONAL