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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Kcne4 | Rat | 17beta-estradiol | multiple interactions | ISO | KCNE4 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of KCNE4 mRNA and [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of KCNE4 mRNA | CTD | PMID:19619570 and PMID:20660070 | Kcne4 | Rat | 17beta-estradiol | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of KCNE4 mRNA | CTD | PMID:19619570 | Kcne4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | KCNE4 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of KCNE4 mRNA | CTD | PMID:19619570 | Kcne4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNE4 mRNA | CTD | PMID:29673856 | Kcne4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNE4 mRNA | CTD | PMID:19619570 | Kcne4 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | Kcne4 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Kcne4 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Kcne4 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KCNE4 mRNA | CTD | PMID:30951980 | Kcne4 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KCNE4 mRNA | CTD | PMID:28973697 | Kcne4 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KCNE4 mRNA | CTD | PMID:24780913 | Kcne4 | Rat | 8-Br-cAMP | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of KCNE4 mRNA | CTD | PMID:22079614 | Kcne4 | Rat | anthra[1,9-cd]pyrazol-6(2H)-one | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | pyrazolanthrone promotes the reaction [Ozone results in increased expression of KCNE4 mRNA] | CTD | PMID:17460151 | Kcne4 | Rat | aristolochic acid A | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KCNE4 mRNA | CTD | PMID:33212167 | Kcne4 | Rat | arsane | decreases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Arsenic results in decreased expression of KCNE4 mRNA | CTD | PMID:19654921 | Kcne4 | Rat | arsenic atom | decreases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Arsenic results in decreased expression of KCNE4 mRNA | CTD | PMID:19654921 | Kcne4 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of KCNE4 gene | CTD | PMID:35440735 | Kcne4 | Rat | benzo[a]pyrene | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to KCNE4 promoter] | CTD | PMID:19654925 | Kcne4 | Rat | benzo[a]pyrene | affects methylation | ISO | KCNE4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KCNE4 exon and Benzo(a)pyrene affects the methylation of KCNE4 promoter | CTD | PMID:27901495 | Kcne4 | Rat | benzo[a]pyrene | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KCNE4 mRNA | CTD | PMID:22228805 and PMID:27195522 | Kcne4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCNE4 mRNA | CTD | PMID:25181051 and PMID:27178563 | Kcne4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCNE4 mRNA | CTD | PMID:30816183 | Kcne4 | Rat | bisphenol A | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of KCNE4 mRNA | CTD | PMID:29275510 | Kcne4 | Rat | bisphenol A | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KCNE4 mRNA | CTD | PMID:30951980 and PMID:32156529 | Kcne4 | Rat | bisphenol A | decreases expression | ISO | Kcne4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of KCNE4 mRNA | CTD | PMID:25594700 | Kcne4 | Rat | bisphenol F | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | bisphenol F results in increased expression of KCNE4 mRNA | CTD | PMID:30951980 | Kcne4 | Rat | cadmium atom | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KCNE4 mRNA | CTD | PMID:37325564 | Kcne4 | Rat | cadmium dichloride | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KCNE4 mRNA | CTD | PMID:37325564 | Kcne4 | Rat | carbon nanotube | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Kcne4 | Rat | CGP 52608 | multiple interactions | ISO | KCNE4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KCNE4 gene] | CTD | PMID:28238834 | Kcne4 | Rat | cisplatin | decreases phosphorylation | ISO | Kcne4 (Mus musculus) | 6480464 | Cisplatin results in decreased phosphorylation of KCNE4 protein | CTD | PMID:22006019 | Kcne4 | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of KCNE4 mRNA | CTD | PMID:24386269 | Kcne4 | Rat | dioxygen | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of KCNE4 mRNA | CTD | PMID:20880076 | Kcne4 | Rat | dioxygen | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KCNE4 mRNA | CTD | PMID:30529165 | Kcne4 | Rat | diquat | decreases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Diquat results in decreased expression of KCNE4 mRNA | CTD | PMID:36851058 | Kcne4 | Rat | doxorubicin | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of KCNE4 mRNA | CTD | PMID:29803840 | Kcne4 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of KCNE4 mRNA | CTD | PMID:29391264 | Kcne4 | Rat | folic acid | decreases expression | ISO | Kcne4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of KCNE4 mRNA | CTD | PMID:25629700 | Kcne4 | Rat | GW 4064 | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | GW 4064 results in increased expression of KCNE4 mRNA | CTD | PMID:26655953 | Kcne4 | Rat | lead(0) | affects expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Lead affects the expression of KCNE4 mRNA | CTD | PMID:28903495 | Kcne4 | Rat | methotrexate | affects expression | ISO | Kcne4 (Mus musculus) | 6480464 | Methotrexate affects the expression of KCNE4 mRNA | CTD | PMID:18502557 | Kcne4 | Rat | nickel atom | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Nickel results in increased expression of KCNE4 mRNA | CTD | PMID:25583101 | Kcne4 | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of KCNE4 mRNA | CTD | PMID:33484710 | Kcne4 | Rat | ozone | multiple interactions | ISO | Kcne4 (Mus musculus) | 6480464 | pyrazolanthrone promotes the reaction [Ozone results in increased expression of KCNE4 mRNA] | CTD | PMID:17460151 | Kcne4 | Rat | paracetamol | affects expression | ISO | Kcne4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KCNE4 mRNA | CTD | PMID:17562736 | Kcne4 | Rat | paracetamol | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KCNE4 mRNA | CTD | PMID:26690555 | Kcne4 | Rat | progesterone | multiple interactions | ISO | KCNE4 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in increased expression of KCNE4 mRNA | CTD | PMID:20660070 | Kcne4 | Rat | progesterone | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Progesterone results in increased expression of KCNE4 mRNA | CTD | PMID:21795739 | Kcne4 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of KCNE4 mRNA | CTD | PMID:33725128 | Kcne4 | Rat | titanium dioxide | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of KCNE4 mRNA | CTD | PMID:23557971 | Kcne4 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of KCNE4 mRNA | CTD | PMID:33387578 | Kcne4 | Rat | triclosan | increases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Triclosan results in increased expression of KCNE4 mRNA | CTD | PMID:30510588 | Kcne4 | Rat | trimellitic anhydride | increases expression | ISO | Kcne4 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of KCNE4 mRNA | CTD | PMID:19042947 | Kcne4 | Rat | urethane | decreases expression | ISO | KCNE4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of KCNE4 mRNA | CTD | PMID:28818685 | Kcne4 | Rat | valproic acid | decreases methylation | ISO | KCNE4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of KCNE4 gene | CTD | PMID:29154799 | |