Spink2 (serine peptidase inhibitor, Kazal type 2) - Rat Genome Database

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Gene: Spink2 (serine peptidase inhibitor, Kazal type 2) Rattus norvegicus
Analyze
Symbol: Spink2
Name: serine peptidase inhibitor, Kazal type 2
RGD ID: 1302956
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in acrosome assembly. Predicted to act upstream of or within several processes, including male germ cell proliferation; negative regulation of serine-type endopeptidase activity; and seminiferous tubule development. Predicted to be located in cytoplasm and neuron projection. Predicted to be active in acrosomal vesicle. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2); INTERACTS WITH acrylamide; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kazal type serine protease inhibitor 2; LOC100910138; serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); serine protease inhibitor Kazal-type 2; serine protease inhibitor Kazal-type 2-like; serine protease inhibitor Kazal-type2; serine protease inhibitor, Kazal type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,321,976 - 31,328,622 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,322,010 - 31,328,622 (+)EnsemblGRCr8
mRatBN7.21430,967,682 - 30,974,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,967,714 - 30,974,326 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,346,157 - 31,352,477 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,654,484 - 32,660,806 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,139,138 - 31,145,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,247,278 - 33,253,913 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,247,274 - 33,253,913 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1433,906,821 - 33,913,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01433,038,333 - 33,044,841 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,245,183 - 33,251,691 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,281,809 - 30,288,317 (+)NCBICelera
RGSC_v3.11433,245,182 - 33,251,442 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2751646   PMID:15057822   PMID:21705336   PMID:24699552   PMID:28554943   PMID:36462395  


Genomics

Comparative Map Data
Spink2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,321,976 - 31,328,622 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,322,010 - 31,328,622 (+)EnsemblGRCr8
mRatBN7.21430,967,682 - 30,974,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,967,714 - 30,974,326 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,346,157 - 31,352,477 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,654,484 - 32,660,806 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,139,138 - 31,145,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,247,278 - 33,253,913 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,247,274 - 33,253,913 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1433,906,821 - 33,913,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01433,038,333 - 33,044,841 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,245,183 - 33,251,691 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,281,809 - 30,288,317 (+)NCBICelera
RGSC_v3.11433,245,182 - 33,251,442 (+)NCBI
Cytogenetic Map14p11NCBI
SPINK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,809,860 - 56,821,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,809,860 - 56,821,742 (-)Ensemblhg38GRCh38
GRCh37457,676,026 - 57,688,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,370,791 - 57,382,650 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34457,516,961 - 57,528,821NCBI
Celera455,182,079 - 55,193,941 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,629,453 - 53,641,463 (-)NCBIHuRef
CHM1_1457,711,128 - 57,723,138 (-)NCBICHM1_1
T2T-CHM13v2.0460,297,771 - 60,309,781 (-)NCBIT2T-CHM13v2.0
Spink2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,352,953 - 77,364,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,352,954 - 77,359,318 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38577,205,106 - 77,216,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,205,107 - 77,211,471 (-)Ensemblmm10GRCm38
MGSCv37577,634,133 - 77,640,478 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36578,279,883 - 78,286,228 (-)NCBIMGSCv36mm8
Celera574,471,870 - 74,478,375 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.53NCBI
Spink2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544714,285,248 - 14,291,835 (+)NCBIChiLan1.0ChiLan1.0
SPINK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,957,685 - 72,969,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,163,245 - 73,175,274 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,101,686 - 67,113,671 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,671,707 - 73,683,685 (+)NCBIPanPan1.1PanPan1.1panPan2
SPINK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11348,952,869 - 48,964,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1348,944,135 - 48,964,831 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1348,843,656 - 48,855,653 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01349,567,563 - 49,580,138 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,444,709 - 49,580,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,239,853 - 49,251,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,768,895 - 48,781,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,713,793 - 49,726,350 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spink2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,328,005 - 27,333,053 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,965,181 - 18,970,209 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,965,186 - 18,970,189 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1855,982,377 - 55,989,592 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,511,290 - 57,518,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,850,394 - 11,862,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606612,518,005 - 12,529,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476112,630,185 - 12,663,637 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink2
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000051031
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat

Markers in Region
BM389183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21430,970,443 - 30,970,641 (+)MAPPERmRatBN7.2
Rnor_6.01433,909,566 - 33,909,763NCBIRnor6.0
Rnor_6.01433,250,031 - 33,250,228NCBIRnor6.0
Rnor_5.01433,694,083 - 33,694,280UniSTSRnor5.0
Rnor_5.01433,040,959 - 33,041,156UniSTSRnor5.0
RGSC_v3.41433,247,809 - 33,248,006UniSTSRGSC3.4
Celera1430,284,435 - 30,284,632UniSTS
RH 3.4 Map14409.9UniSTS
Cytogenetic Map14p11UniSTS
AU049082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21430,967,384 - 30,967,569 (+)MAPPERmRatBN7.2
Rnor_6.01433,246,972 - 33,247,156NCBIRnor6.0
Rnor_6.01433,906,507 - 33,906,691NCBIRnor6.0
Rnor_5.01433,037,900 - 33,038,084UniSTSRnor5.0
Rnor_5.01433,691,024 - 33,691,208UniSTSRnor5.0
RGSC_v3.41433,244,750 - 33,244,934UniSTSRGSC3.4
Celera1430,281,376 - 30,281,568UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 12 39 49 78 66 6 35 5 26 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000051031   ⟹   ENSRNOP00000040692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1433,906,821 - 33,913,450 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075226   ⟹   ENSRNOP00000067011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1433,247,274 - 33,253,913 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114126   ⟹   ENSRNOP00000093491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,322,010 - 31,328,622 (+)Ensembl
mRatBN7.2 Ensembl1430,967,714 - 30,974,326 (+)Ensembl
RefSeq Acc Id: NM_001008870   ⟹   NP_001008870
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,322,114 - 31,328,622 (+)NCBI
mRatBN7.21430,967,818 - 30,974,326 (+)NCBI
Rnor_6.01433,247,405 - 33,253,913 (+)NCBI
Rnor_5.01433,038,333 - 33,044,841 (+)NCBI
RGSC_v3.41433,245,183 - 33,251,691 (+)RGD
Celera1430,281,809 - 30,288,317 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599326   ⟹   XP_017454815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,321,976 - 31,326,368 (+)NCBI
mRatBN7.21430,967,682 - 30,972,072 (+)NCBI
Rnor_6.01433,247,278 - 33,251,659 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008870 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454815 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51396 (Get FASTA)   NCBI Sequence Viewer  
  EDL89879 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093491
GenBank Protein Q6IE49 (Get FASTA)   NCBI Sequence Viewer  
  QGQ76738 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008870   ⟸   NM_001008870
- Peptide Label: precursor
- UniProtKB: Q6IE49 (UniProtKB/Swiss-Prot),   A0A650C5B7 (UniProtKB/TrEMBL),   A0A8I6AIW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454815   ⟸   XM_017599326
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000067011   ⟸   ENSRNOT00000075226
Ensembl Acc Id: ENSRNOP00000040692   ⟸   ENSRNOT00000051031
Ensembl Acc Id: ENSRNOP00000093491   ⟸   ENSRNOT00000114126
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE49-F1-model_v2 AlphaFold Q6IE49 1-86 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302956 AgrOrtholog
BioCyc Gene G2FUF-15985 BioCyc
Ensembl Genes ENSRNOG00000031710 Ensembl
  ENSRNOG00000047065 Ensembl
  ENSRNOG00000066503 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000114126 ENTREZGENE
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  SPINK2 UniProtKB/Swiss-Prot
KEGG Report rno:408234 UniProtKB/Swiss-Prot
NCBI Gene 408234 ENTREZGENE
PANTHER PTHR47608 UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 2 UniProtKB/Swiss-Prot
Pfam Kazal_1 UniProtKB/Swiss-Prot
PhenoGen Spink2 PhenoGen
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031710 RatGTEx
  ENSRNOG00000047065 RatGTEx
  ENSRNOG00000066503 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt A0A650C5B7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIW1 ENTREZGENE, UniProtKB/TrEMBL
  ISK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spink2  serine peptidase inhibitor, Kazal type 2  LOC100910138  serine protease inhibitor Kazal-type 2-like  Data merged from RGD:6500262 737654 PROVISIONAL
2016-03-08 Spink2  serine peptidase inhibitor, Kazal type 2  Spink2  serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910138  serine protease inhibitor Kazal-type 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Spink2  serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)  Spink2  serine peptidase inhibitor, Kazal type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Spink2  serine peptidase inhibitor, Kazal type 2  Spink2  serine protease inhibitor, Kazal type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Spink2  serine protease inhibitor, Kazal type 2      Name updated 1299863 APPROVED
2005-02-14 Spink2  Kazal type serine protease inhibitor 2      Symbol and Name status set to provisional 70820 PROVISIONAL