Kit<sup>Ws</sup> (KIT proto-oncogene receptor tyrosine kinase; mutant 1) - Rat Genome Database

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Gene: KitWs (KIT proto-oncogene receptor tyrosine kinase; mutant 1) Rattus norvegicus
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Symbol: KitWs
Name: KIT proto-oncogene receptor tyrosine kinase; mutant 1
RGD ID: 12910763
Description: A spontaneous 12-bp deletion mutation in the tyrosine kinase domain of the c-Kit gene was identified in the white spotting rat.
ASSOCIATED WITH abnormal interstitial cell of Cajal morphology; absent mast cells; belly spot; ASSOCIATED WITH aplastic anemia
Type: allele  of Kit  
Previously known as: Kit^[Ws]; KitWs
Is Marker For: Strains:   BN-KitWs   Slc:WSRC-KitWs  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats. Albertí E, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1499-510. Epub 2007 Feb 22.
2. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Isozaki K, etal., Gastroenterology. 1995 Aug;109(2):456-64.
3. Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. Katafuchi T, etal., Learn Mem. 2000 Nov-Dec;7(6):383-92.
4. Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit. Morimoto M, etal., Blood. 1993 Dec 1;82(11):3315-20.
5. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Niwa Y, etal., Blood. 1991 Oct 15;78(8):1936-41.
6. Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene. Tsujimura T, etal., Blood 1991 Oct 15;78(8):1942-6.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
KitWs-var1 chr14 32554595 32554606 ATTTCCTTTTAC - deletion mRatBN7.2
KitWs-var1 chr14 35079269 35079280 ATTTCCTTTTAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to KitWs
BN-KitWs     Slc:WSRC-KitWs    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information