Kit<sup>Ws</sup> (KIT proto-oncogene receptor tyrosine kinase; mutant 1) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: KitWs (KIT proto-oncogene receptor tyrosine kinase; mutant 1) Rattus norvegicus
Analyze
Symbol: KitWs
Name: KIT proto-oncogene receptor tyrosine kinase; mutant 1
RGD ID: 12910763
Description: A spontaneous 12-bp deletion mutation in the tyrosine kinase domain of the c-Kit gene was identified in the white spotting rat.
ASSOCIATED WITH abnormal interstitial cell of Cajal morphology; absent mast cells; belly spot; ASSOCIATED WITH aplastic anemia
Type: allele  of Kit  
Previously known as: KitWs
Is Marker For: Strains:   BN-KitWs  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats. Albertí E, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1499-510. Epub 2007 Feb 22.
2. Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. Katafuchi T, etal., Learn Mem. 2000 Nov-Dec;7(6):383-92.
3. Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit. Morimoto M, etal., Blood. 1993 Dec 1;82(11):3315-20.
4. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Niwa Y, etal., Blood. 1991 Oct 15;78(8):1936-41.
5. Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene. Tsujimura T, etal., Blood 1991 Oct 15;78(8):1942-6.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
KitWs-var1 chr14 32554595 32554606 ATTTCCTTTTAC - deletion mRatBN7.2
KitWs-var1 chr14 35079269 35079280 ATTTCCTTTTAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to KitWs


Expression


Sequence

Nucleotide Sequences


Additional Information