Lepr<sup>em3</sup> (leptin receptor; TALEN induced mutant 3) - Rat Genome Database

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Gene: Leprem3 (leptin receptor; TALEN induced mutant 3) Rattus norvegicus
Symbol: Leprem3
Name: leptin receptor; TALEN induced mutant 3
RGD ID: 12910546
Description: This allele was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 18-bp insertion.
ASSOCIATED WITH impaired glucose tolerance; increased circulating alanine transaminase level; increased circulating aspartate transaminase level; ASSOCIATED WITH obesity
Type: allele  of Lepr  
Previously known as: Lepr^[em3]; Leprem3
Is Marker For: Strains:   SD-Leprem3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View
obesity  (IMP)


References - curated
# Reference Title Reference Citation
1. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.


Related Rat Strains
The following Strains have been annotated to Leprem3



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Leprem3  leptin receptor; TALEN induced mutant 3  Leprem3    changed 629549 APPROVED