Ifnar1<sup>em2</sup> (interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2) - Rat Genome Database

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Gene: Ifnar1em2 (interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2) Rattus norvegicus
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Symbol: Ifnar1em2
Name: interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2
RGD ID: 12910496
Description: An Ifnar1 target region in exon 4, encoding the IFN-binding domain, was disrupted in the genome of the LEW.1WR1 rat using the CRISPR-Cas9 method. The resulting mutant carries a 81-bp deletion and 4-bp insertion in the exon 4 of Ifnar1 gene.
ASSOCIATED WITH decreased susceptibility to autoimmune diabetes; increased susceptibility to viral infection induced morbidity/mortality; insulitis; ASSOCIATED WITH Cardiovirus Infections; Experimental Diabetes Mellitus
Type: allele  of Ifnar1  
Previously known as: Ifnar1^[em2]; Ifnar1em2
Is Marker For: Strains:   LEW.1WR1-Ifnar1em2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Qaisar N, etal., Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7.

Genomics


Related Rat Strains
The following Strains have been annotated to Ifnar1em2
LEW.1WR1-Ifnar1em2    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information