Tp53<sup>em1Sage</sup> (tumor protein p53; ZFN induced mutant 1, Sage)

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Gene: Tp53^em1Sage (tumor protein p53; ZFN induced mutant 1, Sage) Rattus norvegicus

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Symbol:	Tp53^em1Sage
Name:	tumor protein p53; ZFN induced mutant 1, Sage
RGD ID:	12904898
Description:	This ZFN allele exhibits a 11 base pair deletion in the rat Tp53 gene. ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH Hypogonadism and Testicular Atrophy
Type:	allele of Tp53
Previously known as:	Tp53 tm1sage; Tp53em1Sage; tumor protein p53; endonuclease induced mutant 1, Sage
Is Marker For:	Strains: SD-Tp53^em1Sage
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hypogonadism and Testicular Atrophy (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal vacuole morphology (IMP)

decreased body weight (IMP)

decreased testis weight (IMP)

increased cellular sensitivity to ionizing radiation (IMP)

increased tumor incidence (IMP)

seminiferous tubule degeneration (IMP)

small epididymis (IMP)

small seminiferous tubules (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat.	Dai MS, etal., Andrology. 2017 Nov;5(6):1141-1152. doi: 10.1111/andr.12409. Epub 2017 Aug 22.
2.	Data curation from Horizon Discovery	Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
3.	Creation and preliminary characterization of a Tp53 knockout rat.	McCoy A, etal., Dis Model Mech. 2013 Jan;6(1):269-78. doi: 10.1242/dmm.009704. Epub 2012 Aug 23.

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Tp53em1Sage-var1	chr10	54307287	54307297	AGATGATATTC	-	deletion	mRatBN7.2
Tp53em1Sage-var1	chr10	56194211	56194221	AGATGATATTC	-	deletion	Rnor_6.0

Related Rat Strains

The following Strains have been annotated to Tp53^em1Sage

SD-Tp53^em1Sage

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-20	Tp53^em1Sage	tumor protein p53; ZFN induced mutant 1, Sage	Tp53^em1Sage	tumor protein p53; endonuclease induced mutant 1, Sage	Name changed	629549	APPROVED

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype