Tp53<sup>em1Sage</sup> (tumor protein p53; ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Tp53em1Sage (tumor protein p53; ZFN induced mutant 1, Sage) Rattus norvegicus
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Symbol: Tp53em1Sage
Name: tumor protein p53; ZFN induced mutant 1, Sage
RGD ID: 12904898
Description: This ZFN allele exhibits a 11 base pair deletion in the rat Tp53 gene.
ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH Hypogonadism and Testicular Atrophy
Type: allele  of Tp53  
Previously known as: Tp53 tm1sage; Tp53em1Sage; tumor protein p53; endonuclease induced mutant 1, Sage
Is Marker For: Strains:   SD-Tp53em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Dai MS, etal., Andrology. 2017 Nov;5(6):1141-1152. doi: 10.1111/andr.12409. Epub 2017 Aug 22.
2. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
3. Creation and preliminary characterization of a Tp53 knockout rat. McCoy A, etal., Dis Model Mech. 2013 Jan;6(1):269-78. doi: 10.1242/dmm.009704. Epub 2012 Aug 23.

Genomics


Related Rat Strains
The following Strains have been annotated to Tp53em1Sage


Expression


Sequence

Nucleotide Sequences

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Tp53em1Sage-var1 chr10 54307287 54307297 AGATGATATTC - deletion
Tp53em1Sage-var1 chr10 56194211 56194221 AGATGATATTC - deletion

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Tp53em1Sage  tumor protein p53; ZFN induced mutant 1, Sage  Tp53em1Sage  tumor protein p53; endonuclease induced mutant 1, Sage  Name changed 629549 APPROVED