Abcb1a<sup>em1Sage</sup> (ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Abcb1aem1Sage (ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage) Rattus norvegicus
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Symbol: Abcb1aem1Sage
Name: ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage
RGD ID: 12904058
Description: This ZFN mutant allelic contain a 20-bp deletion within Abcba1 gene, resulting knockout of protein expression via Western blot.
ASSOCIATED WITH abnormal xenobiotic pharmacokinetics
Type: allele  of Abcb1a  
Previously known as: Abcb1a tm1sage; Abcb1aem1Sage; Abcb1a^[em1Sage]; Abcb1aem1Sage; ATP binding cassette subfamily B member 1A; endonuclease induced mutant 1, Sage
Is Marker For: Strains:   SD-Abcb1aem1Sage -/-   SD-Abcb1aem1Sage Abcg2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats. Liu X, etal., Drug Metab Dispos. 2014 Apr;42(4):482-91. doi: 10.1124/dmd.113.055590. Epub 2014 Jan 7.
3. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.

Genomics


Related Rat Strains
The following Strains have been annotated to Abcb1aem1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-24 Abcb1aem1Sage  ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage  Abcb1aem1Sage  ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage  Symbol changed 629549 APPROVED
2017-06-20 Abcb1aem1Sage  ATP binding cassette subfamily B member 1A; ZFN induced mutant 1, Sage  Abcb1aem1Sage  ATP binding cassette subfamily B member 1A; endonuclease induced mutant 1, Sage  Name changed 629549 APPROVED