Bdnf<sup>em1Sage</sup> (brain-derived neurotrophic factor; ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Bdnfem1Sage (brain-derived neurotrophic factor; ZFN induced mutant 1, Sage) Rattus norvegicus
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Symbol: Bdnfem1Sage
Name: brain-derived neurotrophic factor; ZFN induced mutant 1, Sage
RGD ID: 12902622
Description: This is a ZFN induced knockout allele. Homozygous knockout rats exhibit complete loss of BDNF protein and have a lifespan of 2-3 days.
ASSOCIATED WITH addiction; cocaine preference; high preference for an addictive substance; ASSOCIATED WITH Cocaine-Related Disorders
Type: allele  of Bdnf  
Previously known as: Bdnf^[em1Sage]; Bdnfem1Sage; brain-derived neurotrophic factor; endonuclease induced mutant 1, SAGE
Is Marker For: Strains:   SD-Bdnfem1Sage+/-  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats. St Laurent R, etal., Neurosci Lett. 2013 Jun 7;544:94-9. doi: 10.1016/j.neulet.2013.03.050. Epub 2013 Apr 9.

Genomics


Related Rat Strains
The following Strains have been annotated to Bdnfem1Sage
SD-Bdnfem1Sage+/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Bdnfem1Sage  brain-derived neurotrophic factor; ZFN induced mutant 1, Sage  Bdnfem1Sage  brain-derived neurotrophic factor; endonuclease induced mutant 1, SAGE  Name changed 629549 APPROVED