Bdnf<sup>em1Sage</sup> (brain-derived neurotrophic factor; ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Bdnfem1Sage (brain-derived neurotrophic factor; ZFN induced mutant 1, Sage) Rattus norvegicus
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Symbol: Bdnfem1Sage
Name: brain-derived neurotrophic factor; ZFN induced mutant 1, Sage
RGD ID: 12902622
Description: This is a ZFN induced knockout allele. Homozygous knockout rats exhibit complete loss of BDNF protein and have a lifespan of 2-3 days.
ASSOCIATED WITH addiction; cocaine preference; high preference for an addictive substance; ASSOCIATED WITH Cocaine-Related Disorders
Type: allele  of Bdnf  
Previously known as: Bdnf^[em1Sage]; Bdnfem1Sage; brain-derived neurotrophic factor; endonuclease induced mutant 1, SAGE
Is Marker For: Strains:   SD-Bdnfem1Sage+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


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Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats. St Laurent R, etal., Neurosci Lett. 2013 Jun 7;544:94-9. doi: 10.1016/j.neulet.2013.03.050. Epub 2013 Apr 9.

Genomics


Related Rat Strains
The following Strains have been annotated to Bdnfem1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Bdnfem1Sage  brain-derived neurotrophic factor; ZFN induced mutant 1, Sage  Bdnfem1Sage  brain-derived neurotrophic factor; endonuclease induced mutant 1, SAGE  Name changed 629549 APPROVED