Apoe<sup>em1Sage</sup> (apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Apoeem1Sage (apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Apoeem1Sage
Name: apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 12880022
Description: The mutant allele was created by targeting the exon 3 of rat Apoe. This mutant allele has a 16-bp deletion in the gene and resulted in loss of Apoe protein in homozygotes.
ASSOCIATED WITH abnormal aorta morphology; increased systemic arterial blood pressure; ASSOCIATED WITH familial hypercholesterolemia
Type: allele  of Apoe  
Previously known as: Apoe^[em1Sage]; Apoeem1Sage; apolipoprotein E; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
Is Marker For: Strains:   SD-Apoeem1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats. Phillips EH, etal., J Vasc Res. 2018;55(1):1-12. doi: 10.1159/000484086. Epub 2017 Nov 23.

Genomics


Related Rat Strains
The following Strains have been annotated to Apoeem1Sage
SD-Apoeem1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-08 Apoeem1Sage  apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Apoeem1Sage  apolipoprotein E; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Name changed 629549 APPROVED