Tg<sup>rdw</sup> (thyroglobulin; rdw mutant) - Rat Genome Database

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Gene: Tgrdw (thyroglobulin; rdw mutant) Rattus norvegicus
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Symbol: Tgrdw
Name: thyroglobulin; rdw mutant
RGD ID: 12879860
Description: This allele has a spontaneous missense mutation, G2320R, in the thyroglobul gene and this mutation is responsible for the congenital dwarfism in the WIC-TgrdwKts rat strain.
ASSOCIATED WITH abnormal endoplasmic reticulum morphology; decreased body weight; decreased circulating levels of thyroid hormone; ASSOCIATED WITH Dwarfism; hypothyroidism; isolated growth hormone deficiency
Type: allele  of Tg  
Previously known as: Tg^[rdw]; Tgrdw; thyroglobulin; rdw mutant
Is Marker For: Strains:   WIC-Tgrdw/Kts  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rescue from dwarfism by thyroid function compensation in rdw rats. Furudate S, etal., Exp Anim. 2005 Oct;54(5):455-60. doi: 10.1538/expanim.54.455.
2. A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats. Hishinuma A, etal., Endocrinology 2000 Nov;141(11):4050-5.
3. [rdw rats, a new hereditary dwarf model in the rat]. Koto M, etal., Jikken Dobutsu. 1988 Jan;37(1):21-30.
4. Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Sakai Y, etal., Anat Rec. 2000 May 1;259(1):60-6.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tgrdw-var1 chr7 98517376 98517376 G C point_mutation mRatBN7.2
Tgrdw-var1 chr7 107567063 107567063 G C point_mutation Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Tgrdw
WIC-Tgrdw/Kts    


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-28 Tgrdw  thyroglobulin; rdw mutant  Tgrdw  thyroglobulin; mutant 1  Name changed 629549 APPROVED
2017-04-28 Tgrdw  thyroglobulin; mutant 1  Tgm1  thyroglobulin; mutant 1  Symbol changed 629549 APPROVED
2017-04-27 Tgm1  thyroglobulin; mutant 1  Tgm1  thyroglobulin; mutant 1  Symbol changed 629549 APPROVED