Nppc<sup>em4Kyo</sup> (natriuretic peptide C; ZFN induced mutant 4, Kyo) - Rat Genome Database

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Gene: Nppcem4Kyo (natriuretic peptide C; ZFN induced mutant 4, Kyo) Rattus norvegicus
Symbol: Nppcem4Kyo
Name: natriuretic peptide C; ZFN induced mutant 4, Kyo
RGD ID: 127284873
Description: This allele was induced by Zinc-finger nucleases (ZFNs) system injuected to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). This Nppcem4Kyo ( delta 774) had a massive deletion within the Nppc gene that included the translation initiation site. Quantitative RT-PCR revealed that the expression of Nppc mRNA in the brain was drastically decreased in homozygous delta 774 mutant rats
ASSOCIATED WITH decreased body length; decreased body weight; decreased cranium length
Type: allele  of Nppc  
Previously known as: Nppc^[em4Kyo]
Is Marker For: Strains:   F344-Nppcem4Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death. Fujii T, etal., PLoS One. 2018 Mar 22;13(3):e0194812. doi: 10.1371/journal.pone.0194812. eCollection 2018.


Related Rat Strains
The following Strains have been annotated to Nppcem4Kyo



Nucleotide Sequences

Additional Information