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Gene: Il2rb (interleukin 2 receptor subunit beta) Ictidomys tridecemlineatus

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Symbol:

Il2rb

Name:

interleukin 2 receptor subunit beta

RGD ID:

12727798

Description:

ENCODES a protein that exhibits interleukin-2 binding (ortholog); interleukin-2 receptor activity (ortholog); INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); allergic disease (ortholog); Animal Toxoplasmosis (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interleukin-2 receptor subunit beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,785,491 - 10,797,317 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,795,940 - 3,805,774 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,795,940 - 3,805,822 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

allergic disease (ISO)

Animal Toxoplasmosis (ISO)

asthma (ISO)

autoimmune disease (ISO)

coccidiosis (ISO)

COVID-19 (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

Experimental Liver Cirrhosis (ISO)

Gastro-Enteropancreatic Neuroendocrine Tumor (ISO)

hepatitis B (ISO)

Human Viral Hepatitis (ISO)

ichthyosis (ISO)

immunodeficiency 63 (ISO)

mastocytosis (ISO)

myasthenia gravis (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

parasitic helminthiasis infectious disease (ISO)

pneumonia (ISO)

rheumatoid arthritis (ISO)

Transplant Rejection (ISO)

type 1 diabetes mellitus (ISO)

Viremia (ISO)

visceral leishmaniasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (IEA,ISO)

immunoglobulin mediated immune response (IEA)

interleukin-15-mediated signaling pathway (IEA)

interleukin-2-mediated signaling pathway (IEA)

negative regulation of apoptotic process (IEA,ISO)

positive regulation of phagocytosis (IEA)

Cellular Component

cell surface (IEA,ISO)

external side of plasma membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

coreceptor activity (IEA)

cytokine receptor activity (IEA)

interleukin-15 receptor activity (IEA)

interleukin-2 binding (IEA,ISO)

interleukin-2 receptor activity (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Il2rb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,785,491 - 10,797,317 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,795,940 - 3,805,774 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,795,940 - 3,805,822 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL2RB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	37,125,838 - 37,175,118 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	37,118,666 - 37,175,118 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,521,878 - 37,571,158 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,851,824 - 35,875,908 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,846,381 - 35,870,462	NCBI
Celera	22	21,322,955 - 21,347,014 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,486,973 - 20,511,039 (-)	NCBI		HuRef
CHM1_1	22	37,481,108 - 37,505,190 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,585,773 - 37,635,037 (-)	NCBI		T2T-CHM13v2.0

Il2rb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,363,456 - 78,396,569 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,363,456 - 78,379,471 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,479,256 - 78,511,621 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,479,256 - 78,495,271 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,310,978 - 78,325,496 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,307,803 - 78,322,277 (-)	NCBI		MGSCv36	mm8
Celera	15	79,943,154 - 79,957,670 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.52	NCBI

Il2rb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,913,828 - 111,928,537 (-)	NCBI		GRCr8
mRatBN7.2	7	110,033,341 - 110,048,054 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	110,033,341 - 110,048,054 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,783,773 - 111,798,546 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	114,007,308 - 114,022,077 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,975,130 - 113,989,824 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,701,338 - 119,716,238 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,701,251 - 119,716,238 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,690,375 - 119,705,275 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	106,371,243 - 106,385,925 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Il2rb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,623,154 - 23,640,259 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,623,567 - 23,640,245 (-)	NCBI	ChiLan1.0	ChiLan1.0

IL2RB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,981,923 - 47,006,008 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,670,496 - 49,694,590 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	18,039,469 - 18,069,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,874,889 - 35,899,038 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,874,898 - 35,899,038 (-)	Ensembl	panpan1.1		panPan2

IL2RB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,370,797 - 27,388,775 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,370,797 - 27,388,775 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,325,543 - 27,343,512 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,162,844 - 28,180,818 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,162,844 - 28,180,812 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,884,492 - 27,902,458 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,193,229 - 28,211,199 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,371,136 - 28,389,104 (+)	NCBI		UU_Cfam_GSD_1.0

IL2RB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,628,962 - 10,650,314 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,610,094 - 10,650,315 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,223,970 - 8,247,389 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL2RB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,830,919 - 19,853,534 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,828,898 - 19,852,988 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	105,975,766 - 105,999,423 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il2rb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,672,432 - 10,683,045 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,662,053 - 10,682,891 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013357256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000026766 ⟹ ENSSTOP00000018180

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936492	3,795,940 - 3,805,774 (+)	Ensembl

RefSeq Acc Id:

XM_013357256 ⟹ XP_013212710

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	10,785,491 - 10,797,317 (+)	NCBI
SpeTri2.0	NW_004936492	3,795,940 - 3,805,822 (+)	NCBI

Sequence:

show sequence

ATGGCAGCCCCTGCTTTGACCTGGAGTCTGCTCCTCCTCCTCCTCCTGCCTCTGGCGTCTGCAG
TGGTGAATGACACGTCGCAGCTCTCGTGCTTCTACAACTCCAAAGCCAACATCTCCTGCGAGTG
GAGCCGGGAGGGGGGCCCGCAGGGCGCGTCCTGCCAGCTCCACGCCAAGTCCAACGTCCGGCCC
TGGAACAAGACCTGCGAGCTGTCCCCGGGCGGGCAGGCGTCCTGGGCCTGCGACCTGCTCCTCG
GGAAGCCGGATTCCCAGCCCGTGAACGCGGTGGACGTCCTCAACATCAGCGTGGTCTGCTGGGA
GGGCGGGCGGTGGCGCCTGCTGAAGAGCCAGGCCTTCAGGCCCTTCCACAGAATGCGCCTCTTG
GCCCCCGACTCCCTCCAGGTCCTCGAGGTGGGGACCCACACGTGCAACGTGACCTGGCGCACCT
CCCTGGTCTCCCACTACATCGAGTCCTACCTGGAGTTCCAGGTCCGCACGCGGACCCCGGGCCA
CAGCTGGGAGGAGGCCGCCCTGCTGAGCCTCAGGCAGCAGCAGCAATGGATCTGGCTGGAGCAG
CTCACCCCGCGCACCCCGTATGAGCTGCAGGTGCGGGTCAGGCCCCGGCGGGGCGACCACACCG
TGTGGAGCCCCTGGAGCCGGCCGCTGGCCTTCAGGACGAGGCCCGCAGCCCCTGGGAAGGACGC
CCTGCCGCTGCCCTGGTTCAGCCACACCATCCTGGGCCTCGGGGTCGCTGTGGGCCTCATGGTC
TCCGTCTACTTCCTGGCCAACTTCGGGTACATCGGGCCGTGGCTGAAGAAGGTTCTGAAGTGTC
GCATCCCAGACCCCTCAGAGTTCTTCTCCCAGCTGAGCTCCGAGCACGGAGGAGACCTGCAGAA
GTGGCTCTGCTCGCCCCTGCCCTCCACCTCCTTCAGCCCGGGCGGCCCCGCGGCCGAGATCTCG
CCGCTGGAAGTGCTGGACAAGGACGCCAAGGCCACACAGCTGCTCCTGCTGCAGCAGGACAAGG
CGCCCTCGCCCTCGCCCAGCGGTCACTCGCAGACCAGCTGCTTCACCAACCAGGGCTACTTCTT
CTTCCACCTTCCCGACGCCCTGGAGATCGAGCCCTGTCAGGTGTACTTCACCTTTGACCCCTGC
GCGGAGGAGGAGCCCGAAGAGGGCGGGCCTGGGGTGCCCACGGGGTCGCCCCTGCCGCCCCTGC
CGCCCTCGAACGGGGACGAGGATGCCTACTGCACCTTCCCCCCAGGGGATGACCTGCTGCTCTT
CTCGCCCGGTCTCCTCGGAGGCTCCCCCAACACTGCCCCCGGGGGCCGTGGGGCCAGCGCAGAG
AGGCCGCCCTCCTCCCTGCAGGAGGGAGCCCCCCAAGACTGGGGCACCCCGTCCCTAGGGCCTC
TTGTCCCGGCAGCCCCCAACCTGGTGGGTTCTCAGTCCTCCCTGGAGCTAGTCCTGGGAGAGGC
TGGGAGGGAGGACCCTGCCCCTGGCCCCAGGGGAGGAGCCGACTCCTGCCCGGCCAGCCCTCCA
GGGCAAGGCTGGGTCAGAGCCCCTACCTCCGGCCTGGCCCTGAACACGGATGCCTACCTGTCCC
TCCAAGAACTCCAGGATCAGGACCCAGCTCACCTGGTGTAGACTGAGGCCAGTGGGGGAAGGCC
AGCCAGCCACTGCGCCAGGCCTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013212710	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000018180.2
GenBank Protein	KAG3291003	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013212710 ⟸ XM_013357256

- UniProtKB:

I3N1D4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAPALTWSLLLLLLLPLASAVVNDTSQLSCFYNSKANISCEWSREGGPQGASCQLHAKSNVRP
WNKTCELSPGGQASWACDLLLGKPDSQPVNAVDVLNISVVCWEGGRWRLLKSQAFRPFHRMRLL
APDSLQVLEVGTHTCNVTWRTSLVSHYIESYLEFQVRTRTPGHSWEEAALLSLRQQQQWIWLEQ
LTPRTPYELQVRVRPRRGDHTVWSPWSRPLAFRTRPAAPGKDALPLPWFSHTILGLGVAVGLMV
SVYFLANFGYIGPWLKKVLKCRIPDPSEFFSQLSSEHGGDLQKWLCSPLPSTSFSPGGPAAEIS
PLEVLDKDAKATQLLLLQQDKAPSPSPSGHSQTSCFTNQGYFFFHLPDALEIEPCQVYFTFDPC
AEEEPEEGGPGVPTGSPLPPLPPSNGDEDAYCTFPPGDDLLLFSPGLLGGSPNTAPGGRGASAE
RPPSSLQEGAPQDWGTPSLGPLVPAAPNLVGSQSSLELVLGEAGREDPAPGPRGGADSCPASPP
GQGWVRAPTSGLALNTDAYLSLQELQDQDPAHLV

hide sequence

Ensembl Acc Id:

ENSSTOP00000018180 ⟸ ENSSTOT00000026766

Protein Domains

Fibronectin type-III

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027203	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026766.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	Hempt_rcpt_S_F1_CS	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	IL2RB_N1	UniProtKB/TrEMBL
NCBI Gene	Il2rb	ENTREZGENE
PANTHER	CYTOKINE RECEPTOR	UniProtKB/TrEMBL
	INTERLEUKIN-2 RECEPTOR SUBUNIT BETA	UniProtKB/TrEMBL
Pfam	IL2RB_N1	UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/TrEMBL
	HEMATOPO_REC_S_F1	UniProtKB/TrEMBL
SMART	FN3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49265	UniProtKB/TrEMBL
UniProt	I3N1D4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)