Ptpn11 (protein tyrosine phosphatase non-receptor type 11) - Rat Genome Database

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Gene: Ptpn11 (protein tyrosine phosphatase non-receptor type 11) Ictidomys tridecemlineatus
Analyze
Symbol: Ptpn11
Name: protein tyrosine phosphatase non-receptor type 11
RGD ID: 12726557
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); D1 dopamine receptor binding (ortholog); insulin receptor binding (ortholog); INVOLVED IN cellular response to angiotensin (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to insulin-like growth factor stimulus (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); adenocarcinoma (ortholog); FOUND IN mitochondrion (ortholog); plasma membrane raft (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,103,369 - 148,189,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,628,706 - 2,682,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,602,261 - 2,687,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
anogenital venereal wart  (ISO)
aortic valve stenosis  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial heart septal defect 1  (ISO)
atrophic gastritis  (ISO)
autism spectrum disorder  (ISO)
Cafe-au-Lait Spots  (ISO)
cancer  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
cervical cancer  (ISO)
chondroma  (ISO)
Costello syndrome  (ISO)
craniosynostosis  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
Duane retraction syndrome  (ISO)
Dwarfism  (ISO)
embryonal rhabdomyosarcoma  (ISO)
Experimental Leukemia  (ISO)
Failure to Thrive  (ISO)
Fetal Growth Retardation  (ISO)
Funnel Chest  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Haemophilus Infections  (ISO)
Helicobacter Infections  (ISO)
hemorrhagic disease  (ISO)
hepatocellular adenoma  (ISO)
hereditary multiple exostoses  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic scoliosis  (ISO)
influenza  (ISO)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (ISO)
learning disability  (ISO)
leukemia  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
metachondromatosis  (ISO)
microcephaly  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibroma  (ISO)
neurofibromatosis-Noonan syndrome  (ISO)
Noonan Like Syndrome  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 3  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 1  (ISO)
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia  (ISO)
Ollier disease  (ISO)
Osteochondroma  (ISO)
patent ductus arteriosus  (ISO)
patent foramen ovale  (ISO)
ptosis  (ISO)
RASopathy  (ISO)
Right Ventricular Hypertrophy  (ISO)
Romano-Ward Syndrome  (ISO)
scoliosis  (ISO)
spermatogenic failure 57  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
stomach cancer  (ISO)
strabismus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thrombocytopenia  (ISO)
tricuspid valve insufficiency  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrioventricular canal development  (IEA)
axonogenesis  (IEA)
Bergmann glial cell differentiation  (IEA)
brain development  (IEA)
cellular response to angiotensin  (ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cerebellar cortex formation  (IEA)
DNA damage checkpoint signaling  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
ERBB signaling pathway  (IEA)
face morphogenesis  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
genitalia development  (IEA)
glucose homeostasis  (IEA)
heart development  (IEA)
homeostasis of number of cells within a tissue  (IEA)
hormone metabolic process  (IEA)
hormone-mediated signaling pathway  (IEA)
inner ear development  (IEA)
integrin-mediated signaling pathway  (IEA)
intestinal epithelial cell migration  (IEA)
lipid metabolic process  (IEA)
megakaryocyte development  (IEA)
microvillus organization  (IEA)
multicellular organism growth  (IEA)
negative regulation of cell adhesion mediated by integrin  (IEA)
negative regulation of chondrocyte differentiation  (IEA)
negative regulation of cortisol secretion  (IEA)
negative regulation of growth hormone secretion  (IEA)
negative regulation of hormone secretion  (IEA)
negative regulation of insulin secretion  (IEA)
negative regulation of neutrophil activation  (IEA)
negative regulation of T cell proliferation  (IEA)
negative regulation of type I interferon production  (IEA)
neurotrophin TRK receptor signaling pathway  (IEA)
organ growth  (IEA)
peptidyl-tyrosine dephosphorylation  (ISO)
platelet formation  (IEA)
platelet-derived growth factor receptor signaling pathway  (IEA)
positive regulation of D-glucose import  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of hormone secretion  (IEA)
positive regulation of insulin receptor signaling pathway  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IEA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of ossification  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of signal transduction  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
protein dephosphorylation  (ISO)
regulation of cell adhesion mediated by integrin  (IEA)
regulation of MAPK cascade  (IEA)
regulation of protein export from nucleus  (IEA)
regulation of protein-containing complex assembly  (IEA)
signal transduction  (IEA)
smooth muscle cell proliferation  (ISO)
triglyceride metabolic process  (IEA)
vasodilation  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Ptpn11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,103,369 - 148,189,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,628,706 - 2,682,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,602,261 - 2,687,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,418,947 - 112,509,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,418,351 - 112,509,918 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,856,751 - 112,947,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,340,919 - 111,432,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,319,255 - 111,410,436NCBI
Celera12112,483,686 - 112,574,781 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12109,868,826 - 109,960,330 (+)NCBIHuRef
CHM1_112112,825,224 - 112,916,404 (+)NCBICHM1_1
T2T-CHM13v2.012112,395,849 - 112,486,820 (+)NCBIT2T-CHM13v2.0
Ptpn11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,268,596 - 121,329,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,268,596 - 121,329,460 (-)EnsemblGRCm39 Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBIMGSCv36mm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.72NCBI
Ptpn11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,026,079 - 41,085,577 (+)NCBIGRCr8
mRatBN7.21235,365,436 - 35,424,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,383,144 - 35,424,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,539,721 - 36,599,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,150,921 - 37,210,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,203,373 - 36,263,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
RH 3.4 Map12646.0RGD
Cytogenetic Map12q16NCBI
Ptpn11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,934,306 - 9,035,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,934,734 - 9,031,230 (+)NCBIChiLan1.0ChiLan1.0
PTPN11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210120,510,774 - 120,601,930 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112120,507,189 - 120,598,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,016,364 - 110,107,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,412,077 - 113,503,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,435,669 - 113,503,762 (+)Ensemblpanpan1.1panPan2
PTPN11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,989,218 - 10,072,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,989,425 - 10,067,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,107,654 - 10,190,288 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,229,100 - 10,311,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,229,105 - 10,358,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,203,528 - 10,286,110 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,266,437 - 10,349,406 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,314,568 - 10,397,234 (+)NCBIUU_Cfam_GSD_1.0
PTPN11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,202,169 - 39,292,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,703,693 - 41,793,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,658,495 - 107,754,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,658,453 - 107,752,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,330,748 - 137,428,997 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,721,468 - 19,813,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,721,581 - 19,813,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000024462   ⟹   ENSSTOP00000019962
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366682,628,706 - 2,682,448 (+)Ensembl
RefSeq Acc Id: XM_040290939   ⟹   XP_040146873
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118148,103,369 - 148,189,014 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040146873 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000019962.2
GenBank Protein KAG3278951 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040146873   ⟸   XM_040290939
- UniProtKB: I3N6G6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000019962   ⟸   ENSSTOT00000024462
Protein Domains
SH2   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027384 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024462.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene Ptpn11 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr_6 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt I3N6G6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Ptpn11  protein tyrosine phosphatase non-receptor type 11    protein tyrosine phosphatase, non-receptor type 11  Symbol and/or name change 5135510 APPROVED