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Gene: Abl2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) Ictidomys tridecemlineatus

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Symbol:

Abl2

Name:

ABL proto-oncogene 2, non-receptor tyrosine kinase

RGD ID:

12718027

Description:

ENCODES a protein that exhibits ATP binding (inferred); enzyme activator activity (inferred); enzyme binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); actin filament organization (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Abelson tyrosine-protein kinase 2; ABL proto-oncogene 2, non-receptor tyrosine kinase, transcript variant X1; ABL proto-oncogene 2, non-receptor tyrosine kinase, transcript variant X2; c-abl oncogene 2, non-receptor tyrosine kinase; tyrosine-protein kinase ABL2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	91,923,100 - 92,008,043 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	9,824,392 - 9,847,104 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	9,823,790 - 9,847,291 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

1q24 Deletion Syndrome (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (ISO)

actin filament bundle assembly (ISO)

actin filament organization (ISO)

adult walking behavior (ISO)

aggressive behavior (ISO)

alpha-beta T cell differentiation (ISO)

auditory behavior (ISO)

Bergmann glial cell differentiation (ISO)

canonical NF-kappaB signal transduction (ISO)

cell communication (IEA)

cell-cell adhesion (ISO)

cellular response to oxidative stress (IEA)

cellular response to retinoic acid (IEA)

cerebellum morphogenesis (ISO)

circulatory system development (ISO)

dendrite morphogenesis (ISO)

dendritic spine maintenance (ISO)

DN4 thymocyte differentiation (ISO)

epidermal growth factor receptor signaling pathway (ISO)

establishment of localization in cell (ISO)

exploration behavior (ISO)

learning (ISO)

multicellular organism growth (ISO)

negative regulation of cell-cell adhesion (ISO)

negative regulation of endothelial cell apoptotic process (ISO)

negative regulation of Rho protein signal transduction (ISO)

neural tube closure (ISO)

neuroepithelial cell differentiation (ISO)

neuromuscular process controlling balance (ISO)

neuron differentiation (ISO)

neuron remodeling (ISO)

peptidyl-tyrosine phosphorylation (ISO)

phagocytosis (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

platelet-derived growth factor receptor signaling pathway (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of establishment of T cell polarity (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of neuron projection development (IEA,ISO)

positive regulation of T cell migration (ISO)

positive regulation of type II interferon production (ISO)

positive regulation of Wnt signaling pathway, planar cell polarity pathway (ISO)

post-embryonic development (ISO)

protein localization (ISO)

protein phosphorylation (ISO)

regulation of extracellular matrix organization (ISO)

Rho protein signal transduction (ISO)

signaling (IEA)

substrate-dependent cell migration, cell extension (ISO)

synapse maturation (ISO)

visual learning (ISO)

Cellular Component

actin cytoskeleton (ISO)

cytoplasm (IEA)

dendritic spine (ISO)

glutamatergic synapse (ISO)

lamellipodium (ISO)

phagocytic cup (ISO)

postsynapse (ISO)

Molecular Function

ATP binding (IEA)

enzyme activator activity (IEA)

enzyme binding (IEA)

kinase activity (IEA)

magnesium ion binding (IEA)

manganese ion binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

nucleotide binding (IEA)

phosphotyrosine residue binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Abl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	91,923,100 - 92,008,043 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	9,824,392 - 9,847,104 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	9,823,790 - 9,847,291 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	179,099,330 - 179,229,677 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	179,099,330 - 179,229,684 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	179,068,465 - 179,198,812 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	177,335,085 - 177,465,390 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	175,808,413 - 175,930,393	NCBI
Celera	1	152,177,312 - 152,307,714 (-)	NCBI		Celera
Cytogenetic Map	1	q25.2	NCBI
HuRef	1	150,296,029 - 150,426,165 (-)	NCBI		HuRef
CHM1_1	1	180,492,111 - 180,622,356 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	178,454,335 - 178,584,699 (-)	NCBI		T2T-CHM13v2.0

Abl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	156,386,160 - 156,477,189 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	156,386,356 - 156,477,138 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	156,558,590 - 156,649,619 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	156,558,786 - 156,649,568 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	158,488,918 - 158,579,750 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	158,395,726 - 158,479,393 (+)	NCBI		MGSCv36	mm8
Celera	1	158,949,003 - 159,040,041 (+)	NCBI		Celera
Cytogenetic Map	1	G3	NCBI
cM Map	1	67.71	NCBI

Abl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	71,223,902 - 71,319,770 (+)	NCBI		GRCr8
mRatBN7.2	13	68,673,702 - 68,770,846 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	68,673,722 - 68,839,742 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	71,260,527 - 71,356,363 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	72,580,546 - 72,675,673 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	69,842,041 - 69,937,159 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	74,154,533 - 74,333,244 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	74,154,835 - 74,333,244 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	79,074,821 - 79,253,783 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	71,546,918 - 71,915,301 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	13	68,537,724 - 68,702,946 (+)	NCBI		Celera
Cytogenetic Map	13	q22	NCBI

Abl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	18,437,672 - 18,527,698 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	18,435,984 - 18,527,967 (-)	NCBI	ChiLan1.0	ChiLan1.0

ABL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	70,530,839 - 70,660,797 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	70,195,232 - 70,322,490 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	154,586,423 - 154,711,621 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	158,275,334 - 158,313,954 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	158,280,994 - 158,313,915 (-)	Ensembl	panpan1.1		panPan2

ABL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	20,696,659 - 20,735,362 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	20,700,144 - 20,727,410 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	20,144,587 - 20,259,861 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	20,356,575 - 20,471,864 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	20,356,795 - 20,463,911 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	20,263,283 - 20,379,080 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	20,371,214 - 20,487,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	20,506,417 - 20,622,140 (+)	NCBI		UU_Cfam_GSD_1.0

ABL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	120,892,952 - 120,984,695 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	120,888,891 - 120,984,724 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	132,663,636 - 132,782,743 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	50,106,621 - 50,244,002 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	50,216,483 - 50,241,621 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	51,607,771 - 51,778,370 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	3,160,224 - 3,278,787 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	3,160,528 - 3,280,860 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005319756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021722621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040278312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000029626 ⟹ ENSSTOP00000020777

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936481	9,829,133 - 9,847,104 (+)	Ensembl

Ensembl Acc Id:

ENSSTOT00000030601 ⟹ ENSSTOP00000024509

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936481	9,830,372 - 9,847,104 (+)	Ensembl

Ensembl Acc Id:

ENSSTOT00000041375 ⟹ ENSSTOP00000027066

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936481	9,824,392 - 9,837,061 (+)	Ensembl

RefSeq Acc Id:

XM_005319756 ⟹ XP_005319813

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	91,977,598 - 92,008,043 (+)	NCBI
SpeTri2.0	NW_004936481	9,823,790 - 9,847,291 (+)	NCBI

Sequence:

show sequence

ATTAAGCTATAGAGCCAATAATGTTAATGGGGGCAGTTATTTCCTGGCTTTGGCTATGAATCAG
ATAGTAACTATTTCTTTGGTTTTGAAATTGTGGTTTCTTGAGCTAACTTGAGTGATGTAAAAGA
TGAGTCTTGTTAGGCGTTTCCTCTTTTAAAAATTTATTTAGTGTTTTATTATAAACAGATTTTC
TCCAAGGAAACATTTCTCTGTAGTCTTACCTCATCACCCTTAGAAATGAAAACCTTCCTATATG
AACTGATAACTTAGTTTATTACTAAGCTATATGTTACTCACATGTGTGATGAAAATAGCCTTGT
GTTTTTATTTTATACACACATGCACATTTCTGCATTTAATATTCCCAGAACTTTCAGAAGTAAT
TCGATTCTGACTCAGTCTTGTGCTGATTACAGGACATTTTCCTTTAGGCTACCCTCCGCCCATT
TTGGGAGTTGTGAGTGTTTATCCTCTTATTGGTTAACTCTGGCCACTGAGTACATGAGTACATG
TCACATGCATGTGGTGTTGCTTGTCAGAGTGGAATTCTAAGACTTCCTCTTTACATAAAGCAGT
TAAACTTTGTGCTTCTGACCAGCGGCATGGTCTTGGGGACAGTTCTGCTTCCACCTAACAGTTA
TGGCAGAGATCAGAACACATCACGTTGCTGCCTGTGCAGTGAGGCCTCAGGATCTGCTGTACCC
AACTTGACAGATCACTTTGCCAGCTGTGTGGAGGATGGATTTGAGGGAGACAAGACTGGAGGCA
ATAGTCCAGAAGCTTTGCACCGCCCTTATGGTTGTGATGTTGAATCCCAGGCACTGAACGAAGC
TATCAGGTGGAGTTCCAAGGAGAACTTGCTTGGAGCCACTGAGAGTGACCCTAATCTCTTTGTT
GCACTTTATGATTTTGTAGCAAGTGGTGATAACACACTCAGCATCACTAAAGGTGAAAAACTAC
GAGTTCTTGGTTATAACCAGAATGGCGAGTGGAGTGAAGTTCGTTCTAAGAATGGACAGGGTTG
GGTGCCAAGCAACTATATCACCCCAGTAAATAGCCTGGAAAAACATTCCTGGTACCATGGGCCT
GTATCACGCAGTGCAGCCGAGTATCTACTCAGCAGTCTAATCAATGGCAGTTTCCTGGTGCGAG
AAAGTGAGAGCAGCCCTGGGCAGCTGTCCATCTCGCTCAGGTATGAGGGGCGTGTGTATCACTA
CAGGATCAATACCACCACAGACGGCAAGGTGTATGTGACTGCTGAGAGCCGCTTTAGCACTTTG
GCAGAGCTTGTTCACCATCATTCCACAGTGGCTGATGGGCTGGTGACAACATTACACTACCCAG
CACCCAAGTGTAATAAGCCAACAGTCTATGGTGTATCCCCCATCCATGACAAATGGGAAATGGA
ACGAACAGATATTACCATGAAGCACAAACTTGGGGGCGGTCAGTATGGAGAGGTTTATGTTGGT
GTCTGGAAAAAATATAGCCTTACAGTTGCTGTGAAAACACTGAAGGAAGATACCATGGAGGTTG
AAGAATTCCTAAAAGAAGCTGCAGTGATGAAGGAAATCAAGCATCCTAATCTGGTGCAACTATT
AGGTGTGTGTACTTTGGAGCCACCATTTTATATTGTGACTGAATACATGCCATATGGAAATCTG
CTTGATTATCTCAGAGAATGCAACCGAGAAGAGGTGACTGCAGTTGTACTGCTTTACATGGCCA
CTCAGATCTCTTCTGCAATGGAGTATTTAGAGAAGAAGAATTTTATCCATAGAGATCTTGCAGC
ACGCAATTGCCTAGTGGGAGAAAACCATGTGGTAAAAGTGGCTGACTTTGGCTTAAGTAGACTG
ATGACTGGAGATACCTATACTGCTCATGCTGGAGCCAAATTTCCTATTAAATGGACAGCACCAG
AGAGTCTTGCCTACAATACTTTCTCAATTAAATCAGATGTCTGGGCTTTTGGGGTACTATTATG
GGAAATCGCTACATATGGAATGTCACCATACCCAGGTATTGACCTGTCTCAGGTCTATGATCTA
CTGGAAAAAGGATATCGAATGGAACAACCTGAGGGATGCCCTCCTAAAGTTTATGAACTTATGA
GGGCATGCTGGAAATGGAGCCCTGCTGACAGGCCCTCTTTTGCTGAAACACATCAAGCTTTTGA
AACCATGTTCCATGACTCTAGCATTTCTGAAGAGGTAGCCGAGGAGCTTGGGAGAGCTGCCTCC
TCCTCGTCGGTGGTTCCATACCTGCCCCGATTACCTATACTTCCTTCCAAGATGCGGACCCTGA
AAAAACAGGTGGAGAACAAAGAGAACATTGAAGGAGCACAAGATGCCGCAGAAAATCCTGCCTC
CAGTTCAGCACCAGGGTTCATTAGAAGTACACAGGCCTCCAGTGGGTCCCCAGCACTGCCTCGA
AAACAGAGAGACAAGTCACCCAGCAGCCTCTTGGAAGATGCCAAAGAGACATGCTTCACCAGGG
ATAGGAAGGGAGGCTTCTTCAGTTCCTTCATGAAAAAGAGAAATGCTCCCACACCCCCTAAACG
CAGCAGCTCTTTCCGAGAAATGGAGAATCAGCCCCACAAGAAATATGAACTCACGGGTAACTTC
TCACCTGTTGCTTCTCTACAGCATGCTGACGGGTTCTCTTTCACTCCTGCCCAGCAAGAGACGA
ACCTGGTGCCACCCAAGTGCTATGGGGGGAGCTTTGCACAGAGGAACCTCTGTAATGACGACAG
TGGCGGGGGTGGGGGCAGTGGCGCTGCTGGGGGTGGGTGGTCTGGCATCACAGGCTTCTTTACA
CCTCGCTTAATCAAAAAGACACTGGGCTTACGAGCAGGTAAACCTACAGCCAGTGATGACACTT
CCAAGCCTTTTCCAAGGTCCAACTCTACATCTTCCATGTCCTCAGGGCTTCCAGAGCAGGATAG
GATGGCAATGACCCTTCCCAGGAACTGCCAGAGGTCCAAACTCCAGCTGGAAAGGACAGTGTCC
GCCTCTTCTCAGCCAGAAGAGAATGTGGACAGGGCCAGTGACACGCTTCCAAAAAAATCAGAGG
AAGGTGCTGCTCCAGCCAGGGAGAGACCAAAAGCCAAACTGTTGCCCAGAGGAGCCACAGCACT
TCCTCTGAGAGCCCCTTCTGGGGACCCTGCCATGACCGAGAAGGACTCTCCAGGGGTGGGAACG
GCTGGAGTGGCAGCTGCACCCAAGGGCAAGGAGAGGAATGGTGGGGCACGCCTTGGGACGGCTG
GAGTCCCGGAGGATGGAGAGCAGCCAGGCTGGTCTTCTCCAGCCAAGGCTGCGGCCGTCCTTCC
AACCACTCACAACCACAAAGTGCCAGTCCTCATCTCGCCCACTCTCAAACACACTCCAGCGGAC
GTGCAGCTCATTGGCACAGACTCTCAGGGGAATAAATTCAAGCTCTTATCTGAGCATCAGGTCA
CATCCTCTGCAGACAAGGATCGCCCCCGACGGGTAAAACCAAAGTGTGCCCCACCTCCACCGCC
GGTGATGAGACTCCTGCAGCATCCGTCCGTGTGCTCAGACCCTGCGGAAGAGCCAGCTGCCCTG
ACTGCAGGACAGTCCACGTCAGAAACACAGGAAGGAGGGAAAAAGGCAGCTCCAGGGGCAGTGC
CCATCAGTGGGAAAGCTGGGAGGCCGGTGATGCCTCCACCCCAAGTGCCTCTGCCCACATCTTC
CGTCTCGCCAGCCAAGATGGCCAATGGCACAGCAGGTACTAAGGTGGCTCTGAGAAAAACCAAA
CAGGCAGCTGAGAAAATCTCAGCAGACAAAATCAGCAAAGAGGCCCTGCTGGAATGTGCTGACC
TACTGTCCAGTGCAATCACAGAACCTGTGCCCAATAGCCAGCTGGTCGACACTGGACACCAGCT
GCTCGACTACTGCTCAGGCTATGTGGACTGCATCCCCCAGACTCGCAACAAATTCGCCTTCCGA
GAGGCTGTAAGCAAACTGGAGCTCAGCCTGCAGGAGCTGCAGGTGTCCTCAGCAGTTGCTGCTG
TGCCCGGGGCAAACCCTGTCCTTAATAACTTACTGTCCTGTGTACAGGAAATCAGTGACGTGGT
GCAGAGGTAGCCACTGTTAGTCTGGTGGGAAAATGCGTACACATTTCTGGGGGAGAGGGAAAGG
GACATGTTTTCCTGTGTTCTTGTTTTCAAAAAATGAAAGACTGATACTTGAGTGTGTTTATGTG
AAGTACCTCAGATCCCTGAGTTCTCACGTTTACAGGTTCATCTCAAAAATAAAACACAAATCAT
GTGAA

hide sequence

RefSeq Acc Id:

XM_021722621 ⟹ XP_021578296

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	91,977,599 - 92,008,043 (+)	NCBI
SpeTri2.0	NW_004936481	9,823,791 - 9,847,291 (+)	NCBI

Sequence:

show sequence

TTAAGCTATAGAGCCAATAATGTTAATGGGGGCAGTTATTTCCTGGCTTTGGCTATGAATCAGA
TAGTAACTATTTCTTTGGTTTTGAAATTGTGGTTTCTTGAGCTAACTTGAGTGATGTAAAAGAT
GAGTCTTGTTAGGCGTTTCCTCTTTTAAAAATTTATTTAGTGTTTTATTATAAACAGATTTTCT
CCAAGGAAACATTTCTCTGTAGTCTTACCTCATCACCCTTAGAAATGAAAACCTTCCTATATGA
ACTGATAACTTAGTTTATTACTAAGCTATATGTTACTCACATGTGTGATGAAAATAGCCTTGTG
TTTTTATTTTATACACACATGCACATTTCTGCATTTAATATTCCCAGAACTTTCAGAAGTAATT
CGATTCTGACTCAGTCTTGTGCTGATTACAGGACATTTTCCTTTAGGCTACCCTCCGCCCATTT
TGGGAGTTGTGAGTGTTTATCCTCTTATTGGTTAACTCTGGCCACTGAGTACATGAGTACATGT
CACATGCATGTGGTGTTGCTTGTCAGAGTGGAATTCTAAGACTTCCTCTTTACATAAAGCAGTT
AAACTTTGTGCTTCTGACCAGCGGCATGGTCTTGGGGACAGTTCTGCTTCCACCTAACAGTTAT
GGCAGAGATCAGAACACATCACGTTGCTGCCTGTGCAGTGAGGCCTCAGGATCTGCTGTACCCA
ACTTGACAGATCACTTTGCCAGCTGTGTGGAGGATGGATTTGAGGGAGACAAGACTGGAGGCAA
TAGTCCAGAAGCTTTGCACCGCCCTTATGGTTGTGATGTTGAATCCCAGGCACTGAACGAAGCT
ATCAGGTGGAGTTCCAAGGAGAACTTGCTTGGAGCCACTGAGAGTGACCCTAATCTCTTTGTTG
CACTTTATGATTTTGTAGCAAGTGGTGATAACACACTCAGCATCACTAAAGGTGAAAAACTACG
AGTTCTTGGTTATAACCAGAATGGCGAGTGGAGTGAAGTTCGTTCTAAGAATGGACAGGGTTGG
GTGCCAAGCAACTATATCACCCCAGTAAATAGCCTGGAAAAACATTCCTGGTACCATGGGCCTG
TATCACGCAGTGCAGCCGAGTATCTACTCAGCAGTCTAATCAATGGCAGTTTCCTGGTGCGAGA
AAGTGAGAGCAGCCCTGGGCAGCTGTCCATCTCGCTCAGGTATGAGGGGCGTGTGTATCACTAC
AGGATCAATACCACCACAGACGGCAAGGTGTATGTGACTGCTGAGAGCCGCTTTAGCACTTTGG
CAGAGCTTGTTCACCATCATTCCACAGTGGCTGATGGGCTGGTGACAACATTACACTACCCAGC
ACCCAAGTGTAATAAGCCAACAGTCTATGGTGTATCCCCCATCCATGACAAATGGGAAATGGAA
CGAACAGATATTACCATGAAGCACAAACTTGGGGGCGGTCAGTATGGAGAGGTTTATGTTGGTG
TCTGGAAAAAATATAGCCTTACAGTTGCTGTGAAAACACTGAAGGAAGATACCATGGAGGTTGA
AGAATTCCTAAAAGAAGCTGCAGTGATGAAGGAAATCAAGCATCCTAATCTGGTGCAACTATTA
GGTGTGTGTACTTTGGAGCCACCATTTTATATTGTGACTGAATACATGCCATATGGAAATCTGC
TTGATTATCTCAGAGAATGCAACCGAGAAGAGGTGACTGCAGTTGTACTGCTTTACATGGCCAC
TCAGATCTCTTCTGCAATGGAGTATTTAGAGAAGAAGAATTTTATCCATAGAGATCTTGCAGCA
CGCAATTGCCTAGTGGGAGAAAACCATGTGGTAAAAGTGGCTGACTTTGGCTTAAGTAGACTGA
TGACTGGAGATACCTATACTGCTCATGCTGGAGCCAAATTTCCTATTAAATGGACAGCACCAGA
GAGTCTTGCCTACAATACTTTCTCAATTAAATCAGATGTCTGGGCTTTTGGGGTACTATTATGG
GAAATCGCTACATATGGAATGTCACCATACCCAGGTATTGACCTGTCTCAGGTCTATGATCTAC
TGGAAAAAGGATATCGAATGGAACAACCTGAGGGATGCCCTCCTAAAGTTTATGAACTTATGAG
GGCATGCTGGAAATGGAGCCCTGCTGACAGGCCCTCTTTTGCTGAAACACATCAAGCTTTTGAA
ACCATGTTCCATGACTCTAGCATTTCTGAAGAGGTAGCCGAGGAGCTTGGGAGAGCTGCCTCCT
CCTCGTCGGTGGTTCCATACCTGCCCCGATTACCTATACTTCCTTCCAAGATGCGGACCCTGAA
AAAACAGGTGGAGAACAAAGAGAACATTGAAGGAGCACAAGATGCCGCAGAAAATCCTGCCTCC
AGTTCAGCACCAGGGTTCATTAGAAGTACACAGGCCTCCAGTGGGTCCCCAGCACTGCCTCGAA
AACAGAGAGACAAGTCACCCAGCAGCCTCTTGGAAGATGCCAAAGAGACATGCTTCACCAGGGA
TAGGAAGGGAGGCTTCTTCAGTTCCTTCATGAAAAAGAGAAATGCTCCCACACCCCCTAAACGC
AGCAGCTCTTTCCGAGAAATGGAGAATCAGCCCCACAAGAAATATGAACTCACGGGGCTTCCAG
AGCAGGATAGGATGGCAATGACCCTTCCCAGGAACTGCCAGAGGTCCAAACTCCAGCTGGAAAG
GACAGTGTCCGCCTCTTCTCAGCCAGAAGAGAATGTGGACAGGGCCAGTGACACGCTTCCAAAA
AAATCAGAGGAAGGTGCTGCTCCAGCCAGGGAGAGACCAAAAGCCAAACTGTTGCCCAGAGGAG
CCACAGCACTTCCTCTGAGAGCCCCTTCTGGGGACCCTGCCATGACCGAGAAGGACTCTCCAGG
GGTGGGAACGGCTGGAGTGGCAGCTGCACCCAAGGGCAAGGAGAGGAATGGTGGGGCACGCCTT
GGGACGGCTGGAGTCCCGGAGGATGGAGAGCAGCCAGGCTGGTCTTCTCCAGCCAAGGCTGCGG
CCGTCCTTCCAACCACTCACAACCACAAAGTGCCAGTCCTCATCTCGCCCACTCTCAAACACAC
TCCAGCGGACGTGCAGCTCATTGGCACAGACTCTCAGGGGAATAAATTCAAGCTCTTATCTGAG
CATCAGGTCACATCCTCTGCAGACAAGGATCGCCCCCGACGGGTAAAACCAAAGTGTGCCCCAC
CTCCACCGCCGGTGATGAGACTCCTGCAGCATCCGTCCGTGTGCTCAGACCCTGCGGAAGAGCC
AGCTGCCCTGACTGCAGGACAGTCCACGTCAGAAACACAGGAAGGAGGGAAAAAGGCAGCTCCA
GGGGCAGTGCCCATCAGTGGGAAAGCTGGGAGGCCGGTGATGCCTCCACCCCAAGTGCCTCTGC
CCACATCTTCCGTCTCGCCAGCCAAGATGGCCAATGGCACAGCAGGTACTAAGGTGGCTCTGAG
AAAAACCAAACAGGCAGCTGAGAAAATCTCAGCAGACAAAATCAGCAAAGAGGCCCTGCTGGAA
TGTGCTGACCTACTGTCCAGTGCAATCACAGAACCTGTGCCCAATAGCCAGCTGGTCGACACTG
GACACCAGCTGCTCGACTACTGCTCAGGCTATGTGGACTGCATCCCCCAGACTCGCAACAAATT
CGCCTTCCGAGAGGCTGTAAGCAAACTGGAGCTCAGCCTGCAGGAGCTGCAGGTGTCCTCAGCA
GTTGCTGCTGTGCCCGGGGCAAACCCTGTCCTTAATAACTTACTGTCCTGTGTACAGGAAATCA
GTGACGTGGTGCAGAGGTAGCCACTGTTAGTCTGGTGGGAAAATGCGTACACATTTCTGGGGGA
GAGGGAAAGGGACATGTTTTCCTGTGTTCTTGTTTTCAAAAAATGAAAGACTGATACTTGAGTG
TGTTTATGTGAAGTACCTCAGATCCCTGAGTTCTCACGTTTACAGGTTCATCTCAAAAATAAAA
CACAAATCATGTGAA

hide sequence

RefSeq Acc Id:

XM_040278312 ⟹ XP_040134246

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	91,923,100 - 92,008,043 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005319813	(Get FASTA)	NCBI Sequence Viewer
	XP_021578296	(Get FASTA)	NCBI Sequence Viewer
	XP_040134246	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000020777.2
	ENSSTOP00000024509.1
	ENSSTOP00000027066.1
GenBank Protein	KAG3258646	(Get FASTA)	NCBI Sequence Viewer
	KAG3258647	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005319813 ⟸ XM_005319756
- Peptide Label:	isoform X1
- UniProtKB:	I3N8T1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSHACGVACQSGILRLPLYIKQLNFVLLTSGMVLGTVLLPPNSYGRDQNTSRCCLCSEASGSAV PNLTDHFASCVEDGFEGDKTGGNSPEALHRPYGCDVESQALNEAIRWSSKENLLGATESDPNLF VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHG PVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDGKVYVTAESRFST LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYV GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGN LLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAA SSSSVVPYLPRLPILPSKMRTLKKQVENKENIEGAQDAAENPASSSAPGFIRSTQASSGSPALP RKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGN FSPVASLQHADGFSFTPAQQETNLVPPKCYGGSFAQRNLCNDDSGGGGGSGAAGGGWSGITGFF TPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTV SASSQPEENVDRASDTLPKKSEEGAAPARERPKAKLLPRGATALPLRAPSGDPAMTEKDSPGVG TAGVAAAPKGKERNGGARLGTAGVPEDGEQPGWSSPAKAAAVLPTTHNHKVPVLISPTLKHTPA DVQLIGTDSQGNKFKLLSEHQVTSSADKDRPRRVKPKCAPPPPPVMRLLQHPSVCSDPAEEPAA LTAGQSTSETQEGGKKAAPGAVPISGKAGRPVMPPPQVPLPTSSVSPAKMANGTAGTKVALRKT KQAAEKISADKISKEALLECADLLSSAITEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAF REAVSKLELSLQELQVSSAVAAVPGANPVLNNLLSCVQEISDVVQR hide sequence

RefSeq Acc Id:	XP_021578296 ⟸ XM_021722621
- Peptide Label:	isoform X3
- UniProtKB:	A0A287CTA2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSHACGVACQSGILRLPLYIKQLNFVLLTSGMVLGTVLLPPNSYGRDQNTSRCCLCSEASGSAV PNLTDHFASCVEDGFEGDKTGGNSPEALHRPYGCDVESQALNEAIRWSSKENLLGATESDPNLF VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHG PVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDGKVYVTAESRFST LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYV GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGN LLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAA SSSSVVPYLPRLPILPSKMRTLKKQVENKENIEGAQDAAENPASSSAPGFIRSTQASSGSPALP RKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGL PEQDRMAMTLPRNCQRSKLQLERTVSASSQPEENVDRASDTLPKKSEEGAAPARERPKAKLLPR GATALPLRAPSGDPAMTEKDSPGVGTAGVAAAPKGKERNGGARLGTAGVPEDGEQPGWSSPAKA AAVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSADKDRPRRVKPKCA PPPPPVMRLLQHPSVCSDPAEEPAALTAGQSTSETQEGGKKAAPGAVPISGKAGRPVMPPPQVP LPTSSVSPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSAITEPVPNSQLVD TGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAVAAVPGANPVLNNLLSCVQE ISDVVQR hide sequence

RefSeq Acc Id:	XP_040134246 ⟸ XM_040278312
- Peptide Label:	isoform X2
- UniProtKB:	I3N8T1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000027066 ⟸ ENSSTOT00000041375

Ensembl Acc Id:

ENSSTOP00000020777 ⟸ ENSSTOT00000029626

Ensembl Acc Id:

ENSSTOP00000024509 ⟸ ENSSTOT00000030601

Protein Domains

Protein kinase SH2 SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021312	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000029626.2	UniProtKB/TrEMBL
	ENSSTOT00000030601.1	UniProtKB/TrEMBL
	ENSSTOT00000041375.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	Nucleotidyltransferases domain 2	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	ABL_SH2	UniProtKB/TrEMBL
	F-actin-binding	UniProtKB/TrEMBL
	Grb2-like	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
NCBI Gene	Abl2	ENTREZGENE
PANTHER	PROTEIN ENHANCER OF SEVENLESS 2B	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	F_actin_bind	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	FABD	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A287CTA2	ENTREZGENE, UniProtKB/TrEMBL
	A0A287D0F2_ICTTR	UniProtKB/TrEMBL
	I3N8T1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar