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Gene: Btk (Bruton tyrosine kinase) Ictidomys tridecemlineatus

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Symbol:

Btk

Name:

Bruton tyrosine kinase

RGD ID:

12707326

Description:

ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN cellular response to molecule of fungal origin (ortholog); cellular response to reactive oxygen species (ortholog); eosinophil homeostasis (ortholog); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Adenoviridae Infections (ortholog); agammaglobulinemia (ortholog); agammaglobulinemia 1 (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Bruton tyrosine kinase, transcript variant X1; Bruton tyrosine kinase, transcript variant X2; Bruton tyrosine kinase, transcript variant X3; tyrosine-protein kinase BTK

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BTK (Bruton tyrosine kinase)	NCBI	Ortholog
Mus musculus (house mouse):	Btk (Bruton agammaglobulinemia tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BTK (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Btk (Bruton tyrosine kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	429,224 - 463,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	429,400 - 467,481 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adenoviridae Infections (ISO)

agammaglobulinemia (ISO)

agammaglobulinemia 1 (ISO)

Anaphylaxis (ISO)

arthus reaction (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

B-cell lymphoma (ISO)

Burkitt lymphoma (ISO)

central nervous system lymphoma (ISO)

colitis (ISO)

colon adenocarcinoma (ISO)

colorectal cancer (ISO)

common variable immunodeficiency (ISO)

COVID-19 (ISO)

cryptococcosis (ISO)

deafness-dystonia-optic neuronopathy syndrome (ISO)

developmental and epileptic encephalopathy 9 (ISO)

diffuse large B-cell lymphoma (ISO)

endometriosis of uterus (ISO)

Enterovirus Infections (ISO)

Experimental Arthritis (ISO)

Fabry disease (ISO)

factor VIII deficiency (ISO)

genetic disease (ISO)

Hypothermia (ISO)

influenza A (ISO)

isolated growth hormone deficiency type III (ISO)

leishmaniasis (ISO)

listeriosis (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

mantle cell lymphoma (ISO)

nasopharynx carcinoma (ISO)

oral squamous cell carcinoma (ISO)

Pneumococcal Pneumonia (ISO)

primary immunodeficiency disease (ISO)

ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED (ISO)

Streptococcus pneumonia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked agammaglobulinemia (ISO)

X-Linked Hypogammaglobulinemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell affinity maturation (IEA)

B cell receptor signaling pathway (IEA)

cell maturation (IEA)

cellular response to interleukin-7 (IEA)

cellular response to molecule of fungal origin (ISO)

cellular response to reactive oxygen species (ISO)

eosinophil homeostasis (ISO)

histamine secretion by mast cell (ISO)

intracellular signal transduction (IEA)

monocyte proliferation (ISO)

negative regulation of B cell activation (ISO)

negative regulation of B cell proliferation (IEA)

negative regulation of cytokine production (IEA)

negative regulation of interleukin-10 production (ISO)

negative regulation of leukocyte proliferation (ISO)

neutrophil homeostasis (ISO)

peptidyl-tyrosine autophosphorylation (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of B cell proliferation (ISO)

positive regulation of cGAS/STING signaling pathway (IEA)

positive regulation of immunoglobulin production (ISO)

positive regulation of interleukin-17A production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of NLRP3 inflammasome complex assembly (IEA)

positive regulation of phagocytosis (ISO)

positive regulation of synoviocyte proliferation (ISO)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type I hypersensitivity (ISO)

positive regulation of type III hypersensitivity (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

proteoglycan catabolic process (ISO)

response to lipopolysaccharide (ISO)

Cellular Component

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

cytosol (IEA)

membrane raft (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (ISO)

plasma membrane (IEA)

Molecular Function

ATP binding (IEA)

identical protein binding (IEA)

kinase activity (IEA)

metal ion binding (IEA)

non-membrane spanning protein tyrosine kinase activity (IEA)

nucleotide binding (IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA)

phospholipase activator activity (IEA)

phospholipase binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA,ISO)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

erythropoietin signaling pathway (ISO)

FasL mediated signaling pathway (ISO)

Fc epsilon receptor mediated signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

protein kinase C (PKC) signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	429,224 - 463,441 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	429,400 - 467,481 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BTK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,349,450 - 101,390,796 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,349,338 - 101,390,796 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,604,438 - 100,645,784 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,491,098 - 100,527,838 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,410,586 - 100,447,327	NCBI
Celera	X	101,123,894 - 101,160,669 (-)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,410,583 - 90,447,505 (-)	NCBI		HuRef
CHM1_1	X	100,497,918 - 100,534,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,793,571 - 99,834,908 (-)	NCBI		T2T-CHM13v2.0

Btk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,443,083 - 133,484,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,443,085 - 133,484,319 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,542,334 - 134,583,628 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,542,336 - 134,583,570 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	131,076,880 - 131,117,679 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,888,761 - 129,929,466 (-)	NCBI		MGSCv36	mm8
Celera	X	117,421,885 - 117,462,725 (-)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.18	NCBI

Btk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	102,016,070 - 102,055,448 (-)	NCBI		GRCr8
mRatBN7.2	X	97,722,796 - 97,762,315 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,722,802 - 97,761,853 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,397,016 - 99,436,088 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,907,749 - 102,946,794 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,410,180 - 100,449,237 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,360,922 - 105,390,580 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,360,922 - 105,390,580 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,250,666 - 105,279,934 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,998,935 - 122,030,289 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	122,072,367 - 122,103,722 (-)	NCBI
Celera	X	98,764,036 - 98,794,122 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

Btk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,482,793 - 7,515,120 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,483,819 - 7,515,085 (-)	NCBI	ChiLan1.0	ChiLan1.0

BTK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	100,948,666 - 100,985,544 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	100,952,265 - 100,989,149 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,551,874 - 90,588,786 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,684,017 - 100,720,868 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,684,017 - 100,725,187 (-)	Ensembl	panpan1.1		panPan2

BTK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,270,952 - 75,302,663 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,270,979 - 75,302,562 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,691,359 - 76,723,087 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,691,367 - 76,723,042 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,255,464 - 74,287,205 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,915,885 - 75,947,610 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,678,325 - 75,710,045 (-)	NCBI		UU_Cfam_GSD_1.0

BTK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,981,515 - 83,014,573 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,981,512 - 83,014,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

BTK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,690,569 - 89,727,420 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666065	14,609,796 - 14,647,019 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Btk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,182,682 - 1,216,171 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,173,101 - 1,216,662 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005340689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013365376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021720483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000004745 ⟹ ENSSTOP00000004260

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936813	429,224 - 463,441 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000043134 ⟹ ENSSTOP00000025463

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936813	429,848 - 454,107 (-)	Ensembl

RefSeq Acc Id:

XM_005340689 ⟹ XP_005340746

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	63,011,695 - 63,045,465 (+)	NCBI
SpeTri2.0	NW_004936813	429,400 - 463,411 (-)	NCBI

Sequence:

show sequence

AGACTGTCCTTCCTCTCTGGACTGTAAGAATATGTCTCCAGAGCCAGTGTCTTCGGAGATCGAG
TGCTACCTTCCAAGTCCTGGCATCTCAATGCATCTGGGAAGCTACCTCCATTAAGTCAGAACCA
AGCACACAAGTGAGCCCCAGAAAGAAGAAGTGATGGCTGCAGTGATACTGGAGAGTATCTTTTT
GAAGCGCTCACAGCAAAAAAAGAAAACATCGCCTTTAAACTTCAAGAAGCGTCTCTTTCTCTTG
ACTATGCACAAACTTTCCTACTATGAGTATGACTTTGAACGTGGGAGAAGAGGCAGTAAGAAGG
GTTCAATAGATGTTGAAAAGATCACCTGCGTCGAAACAGTGGTTCCTGAAAAAAATCCTCCCCC
TGAAAGACAAATTCCGAGAAGAGGTGAAGAGTCCAGTGAAATGGAACAGATTTCAATCATTGAA
AGATTTCCTTATCCTTTCCAGGTTGTATATGATGAAGGGCCTCTCTATGTCTTTTCCCCAACTG
AAGAACTGAGAAAGCGTTGGATTCATCAGCTCAAAAATGTAATCCGATACAACAGTGATCTGGT
ACAGAAATACCACCCTTGCTTCTGGATCGATGGGCAGTATCTTTGCTGCTCTCAGACAGCCAAA
AATGCCATGGGCTGCCAAATATTGGAGAACAGGAATGGAAGCTTAAAACCTGGGAGTTCTCACC
GAAAGACAAAAAAGCCTCTTCCCCCCACACCAGAGGAGGACCAGATCTTGAAAAAGCCACTGCC
CCCTGAGCCAACAGCAGCACCAGTCTCCCCGGGAGAGCTGAAAAAGGTTGTGGCCCTTTATGAT
TATATGCCAATGAATGCAAATGACCTACAGCTGAGGAAGGGTGATGAGTATTTTATCCTGGAGG
AGAGCAACCTACCATGGTGGCGAGCACGAGATAAAAATGGGCAGGAAGGCTACATTCCTAGTAA
TTACGTCACTGAAGCAGAAGACTCCATAGAAATGTATGAGTGGTATTCCAAACACATGACTCGG
AGTCAAGCTGAGCAACTACTAAAGCAAGAGGGGAAAGAAGGAGGTTTCATTGTCAGAGACTCGA
GCAAAGCTGGAAAATATACTGTGTCTGTGTTTGCTAAATCTACAGGGGACCCTCAAGGGGTGAT
ACGCCATTATGTTGTGTGTTCCACACCTCAGAGCCAGTATTACCTGGCTGAGAAACACCTTTTC
AGCACCATTCCTGAGCTCATTAATTACCATCAGCATAACTCTGCCGGACTCATATCTAGGCTGA
AATATCCAGTGTCTCAGAAAAACAAGAATGCACCTTCCACTGCAGGCCTGGGCTACGGATCATG
GGAAATCGATCCAAAGGACCTGACTTTCTTGAAGGAGCTTGGAACTGGACAATTTGGAGTAGTA
AAGTATGGGAAATGGAGAGGTCAGTATGATGTGGCCATCAAGATGATCAAAGAAGGCTCCATGT
CTGAAGATGAGTTCATTGAAGAAGCCAAAGTCATGATGAATCTTTCCCATGAGAAGCTGGTGCA
GTTGTATGGCGTCTGCACCAAACAACGCCCCATCTTCATCATCACTGAGTACATGGCCAATGGC
TGCCTCCTGAACTACCTGAGGGAGATGCGCCACCGCTTCCAGACTCAGCAGCTGCTGGAGATGT
GCAAAGATGTCTGTGAAGCCATGGAATACCTGGAGTCAAAGCAGTTCCTTCACCGAGACCTGGC
AGCTCGAAACTGTTTGGTAAATGATCAAGGAGTTGTGAAAGTATCTGACTTTGGCCTGTCCAGA
TATGTCCTGGATGATGAGTACACCAGCTCAGTAGGCTCTAAATTTCCAGTACGGTGGTCTCCAC
CAGAAGTCCTTATGTATAGCAAGTTCAGCAGCAAATCTGACATTTGGGCTTTTGGGGTTTTAAT
GTGGGAAATTTACTCCCTTGGGAAAATGCCATATGAGAGATTTAATAACAGTGAGACTGCTGAA
CATATTGCCAAAGGCCTACGTCTCTATAGGCCTCATCTGGCTTCAGAGAGGGTATATACCATTA
TGTATAGTTGCTGGCATGAGAAAGCAGATGAACGTCCCACTTTCAAAATTCTCCTGAGCAACAT
TCTAGATGTTATGGATGAAGAATCTTGAGCTGGCCCATAAGCTTCTTAGTTCTACTTCTCTCTT
CACAAGCCCCAAATTCATTTTCTCTGAAGAAATTCCAGGCTTGCAGGCTCTAGAGCCTTTATGC
TACCACTGAATACACAAAGGCTCTTCTACATCTAGAAATATAACATCTCTTCTTCAATTTCCCT
GGGATTGAGCTTCTGAGTAAAGGCCAAGGAGTTTCTGTGCCTGGTATTAACCCTCCCTCCCCAA
GAACCCCCACGAAGAGAGGAAATTTCCCAAGACTATTAAGACAGACTGAATTTGGGAAGGAAGT
TTGGGGAGGAGGGAGGCATGTAAATAACCTTGCAAGGGGTCTAAGAGCTCTCTGGTAGGCATTA
GAGCTTGGGGTGGGGCAGAATATGGCAAAATGAAATGGTGTCATAAAAGTGGAGGGGTGTTTGG
ATAAAATAAAATTACTGGAAAGAGTGAA

hide sequence

RefSeq Acc Id:

XM_013365376 ⟹ XP_013220830

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI
SpeTri2.0	NW_004936813	429,400 - 467,481 (-)	NCBI

Sequence:

show sequence

CGACCTCTGGCGGCTGAGAGGACTGGATTCCTAGCCGAGGGTGGGAGCTTCAAGGAAGGGCTCT
CTTCTCCTCCATTTCCTCCAGCCTCCAGACTTTGCAACTTTTCATTTTTGGCGGGCGTTGCTAC
GTAGTATCGTTAAGTGAAGGAAGCAGGGCTCTTTCCAGACTTTCTGGCCTCCCTGTCCCTGAGG
GAAGCCGAGACCAGGGTAGAGTGGAGGAGCTCTTCATCTCTGCATTTTATTCCTGTTCCACCTC
AGCACACAAGTGAGCCCCAGAAAGAAGAAGTGATGGCTGCAGTGATACTGGAGAGTATCTTTTT
GAAGCGCTCACAGCAAAAAAAGAAAACATCGCCTTTAAACTTCAAGAAGCGTCTCTTTCTCTTG
ACTATGCACAAACTTTCCTACTATGAGTATGACTTTGAACGTGGGAGAAGAGGCAGTAAGAAGG
GTTCAATAGATGTTGAAAAGATCACCTGCGTCGAAACAGTGGTTCCTGAAAAAAATCCTCCCCC
TGAAAGACAAATTCCGAGAAGAGGTGAAGAGTCCAGTGAAATGGAACAGATTTCAATCATTGAA
AGATTTCCTTATCCTTTCCAGGTTGTATATGATGAAGGGCCTCTCTATGTCTTTTCCCCAACTG
AAGAACTGAGAAAGCGTTGGATTCATCAGCTCAAAAATGTAATCCGATACAACAGTGATCTGGT
ACAGAAATACCACCCTTGCTTCTGGATCGATGGGCAGTATCTTTGCTGCTCTCAGACAGCCAAA
AATGCCATGGGCTGCCAAATATTGGAGAACAGGAATGGAAGCTTAAAACCTGGGAGTTCTCACC
GAAAGACAAAAAAGCCTCTTCCCCCCACACCAGAGGAGGACCAGATCTTGAAAAAGCCACTGCC
CCCTGAGCCAACAGCAGCACCAGTCTCCCCGGGAGAGCTGAAAAAGGTTGTGGCCCTTTATGAT
TATATGCCAATGAATGCAAATGACCTACAGCTGAGGAAGGGTGATGAGTATTTTATCCTGGAGG
AGAGCAACCTACCATGGTGGCGAGCACGAGATAAAAATGGGCAGGAAGGCTACATTCCTAGTAA
TTACGTCACTGAAGCAGAAGACTCCATAGAAATGTATGAGTGGTATTCCAAACACATGACTCGG
AGTCAAGCTGAGCAACTACTAAAGCAAGAGGGGAAAGAAGGAGGTTTCATTGTCAGAGACTCGA
GCAAAGCTGGAAAATATACTGTGTCTGTGTTTGCTAAATCTACAGGGGACCCTCAAGGGGTGAT
ACGCCATTATGTTGTGTGTTCCACACCTCAGAGCCAGTATTACCTGGCTGAGAAACACCTTTTC
AGCACCATTCCTGAGCTCATTAATTACCATCAGCATAACTCTGCCGGACTCATATCTAGGCTGA
AATATCCAGTGTCTCAGAAAAACAAGAATGCACCTTCCACTGCAGGCCTGGGCTACGGATCATG
GGAAATCGATCCAAAGGACCTGACTTTCTTGAAGGAGCTTGGAACTGGACAATTTGGAGTAGTA
AAGTATGGGAAATGGAGAGGTCAGTATGATGTGGCCATCAAGATGATCAAAGAAGGCTCCATGT
CTGAAGATGAGTTCATTGAAGAAGCCAAAGTCATGATGAATCTTTCCCATGAGAAGCTGGTGCA
GTTGTATGGCGTCTGCACCAAACAACGCCCCATCTTCATCATCACTGAGTACATGGCCAATGGC
TGCCTCCTGAACTACCTGAGGGAGATGCGCCACCGCTTCCAGACTCAGCAGCTGCTGGAGATGT
GCAAAGATGTCTGTGAAGCCATGGAATACCTGGAGTCAAAGCAGTTCCTTCACCGAGACCTGGC
AGCTCGAAACTGTTTGGTAAATGATCAAGGAGTTGTGAAAGTATCTGACTTTGGCCTGTCCAGA
TATGTCCTGGATGATGAGTACACCAGCTCAGTAGGCTCTAAATTTCCAGTACGGTGGTCTCCAC
CAGAAGTCCTTATGTATAGCAAGTTCAGCAGCAAATCTGACATTTGGGCTTTTGGGGTTTTAAT
GTGGGAAATTTACTCCCTTGGGAAAATGCCATATGAGAGATTTAATAACAGTGAGACTGCTGAA
CATATTGCCAAAGGCCTACGTCTCTATAGGCCTCATCTGGCTTCAGAGAGGGTATATACCATTA
TGTATAGTTGCTGGCATGAGAAAGCAGATGAACGTCCCACTTTCAAAATTCTCCTGAGCAACAT
TCTAGATGTTATGGATGAAGAATCTTGAGCTGGCCCATAAGCTTCTTAGTTCTACTTCTCTCTT
CACAAGCCCCAAATTCATTTTCTCTGAAGAAATTCCAGGCTTGCAGGCTCTAGAGCCTTTATGC
TACCACTGAATACACAAAGGCTCTTCTACATCTAGAAATATAACATCTCTTCTTCAATTTCCCT
GGGATTGAGCTTCTGAGTAAAGGCCAAGGAGTTTCTGTGCCTGGTATTAACCCTCCCTCCCCAA
GAACCCCCACGAAGAGAGGAAATTTCCCAAGACTATTAAGACAGACTGAATTTGGGAAGGAAGT
TTGGGGAGGAGGGAGGCATGTAAATAACCTTGCAAGGGGTCTAAGAGCTCTCTGGTAGGCATTA
GAGCTTGGGGTGGGGCAGAATATGGCAAAATGAAATGGTGTCATAAAAGTGGAGGGGTGTTTGG
ATAAAATAAAATTACTGGAAAGAGTGAA

hide sequence

RefSeq Acc Id:

XM_021720483 ⟹ XP_021576158

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	63,007,672 - 63,045,710 (+)	NCBI
SpeTri2.0	NW_004936813	429,400 - 454,197 (-)	NCBI

Sequence:

show sequence

GGGAACCAGGAGGGATGAGAATTAATGCAGTGGAATCTCAAGAACTTTCATTATCAACAGCACA
CAAGTGAGCCCCAGAAAGAAGAAGTGATGGCTGCAGTGATACTGGAGAGTATCTTTTTGAAGCG
CTCACAGCAAAAAAAGAAAACATCGCCTTTAAACTTCAAGAAGCGTCTCTTTCTCTTGACTATG
CACAAACTTTCCTACTATGAGTATGACTTTGAACGTGGGAGAAGAGGCAGTAAGAAGGGTTCAA
TAGATGTTGAAAAGATCACCTGCGTCGAAACAGTGGTTCCTGAAAAAAATCCTCCCCCTGAAAG
ACAAATTCCGAGAAGAGGTGAAGAGTCCAGTGAAATGGAACAGATTTCAATCATTGAAAGATTT
CCTTATCCTTTCCAGGTTGTATATGATGAAGGGCCTCTCTATGTCTTTTCCCCAACTGAAGAAC
TGAGAAAGCGTTGGATTCATCAGCTCAAAAATGTAATCCGATACAACAGTGATCTGGTACAGAA
ATACCACCCTTGCTTCTGGATCGATGGGCAGTATCTTTGCTGCTCTCAGACAGCCAAAAATGCC
ATGGGCTGCCAAATATTGGAGAACAGGAATGGAAGCTTAAAACCTGGGAGTTCTCACCGAAAGA
CAAAAAAGCCTCTTCCCCCCACACCAGAGGAGGACCAGATCTTGAAAAAGCCACTGCCCCCTGA
GCCAACAGCAGCACCAGTCTCCCCGGGAGAGCTGAAAAAGGTTGTGGCCCTTTATGATTATATG
CCAATGAATGCAAATGACCTACAGCTGAGGAAGGGTGATGAGTATTTTATCCTGGAGGAGAGCA
ACCTACCATGGTGGCGAGCACGAGATAAAAATGGGCAGGAAGGCTACATTCCTAGTAATTACGT
CACTGAAGCAGAAGACTCCATAGAAATGTATGAGTGGTATTCCAAACACATGACTCGGAGTCAA
GCTGAGCAACTACTAAAGCAAGAGGGGAAAGAAGGAGGTTTCATTGTCAGAGACTCGAGCAAAG
CTGGAAAATATACTGTGTCTGTGTTTGCTAAATCTACAGGGGACCCTCAAGGGGTGATACGCCA
TTATGTTGTGTGTTCCACACCTCAGAGCCAGTATTACCTGGCTGAGAAACACCTTTTCAGCACC
ATTCCTGAGCTCATTAATTACCATCAGCATAACTCTGCCGGACTCATATCTAGGCTGAAATATC
CAGTGTCTCAGAAAAACAAGAATGCACCTTCCACTGCAGGCCTGGGCTACGGATCATGGGAAAT
CGATCCAAAGGACCTGACTTTCTTGAAGGAGCTTGGAACTGGACAATTTGGAGTAGTAAAGTAT
GGGAAATGGAGAGGTCAGTATGATGTGGCCATCAAGATGATCAAAGAAGGCTCCATGTCTGAAG
ATGAGTTCATTGAAGAAGCCAAAGTCATGATGAATCTTTCCCATGAGAAGCTGGTGCAGTTGTA
TGGCGTCTGCACCAAACAACGCCCCATCTTCATCATCACTGAGTACATGGCCAATGGCTGCCTC
CTGAACTACCTGAGGGAGATGCGCCACCGCTTCCAGACTCAGCAGCTGCTGGAGATGTGCAAAG
ATGTCTGTGAAGCCATGGAATACCTGGAGTCAAAGCAGTTCCTTCACCGAGACCTGGCAGCTCG
AAACTGTTTGGTAAATGATCAAGGAGTTGTGAAAGTATCTGACTTTGGCCTGTCCAGATATGTC
CTGGATGATGAGTACACCAGCTCAGTAGGCTCTAAATTTCCAGTACGGTGGTCTCCACCAGAAG
TCCTTATGTATAGCAAGTTCAGCAGCAAATCTGACATTTGGGCTTTTGGGGTTTTAATGTGGGA
AATTTACTCCCTTGGGAAAATGCCATATGAGAGATTTAATAACAGTGAGACTGCTGAACATATT
GCCAAAGGCCTACGTCTCTATAGGCCTCATCTGGCTTCAGAGAGGGTATATACCATTATGTATA
GTTGCTGGCATGAGAAAGCAGATGAACGTCCCACTTTCAAAATTCTCCTGAGCAACATTCTAGA
TGTTATGGATGAAGAATCTTGAGCTGGCCCATAAGCTTCTTAGTTCTACTTCTCTCTTCACAAG
CCCCAAATTCATTTTCTCTGAAGAAATTCCAGGCTTGCAGGCTCTAGAGCCTTTATGCTACCAC
TGAATACACAAAGGCTCTTCTACATCTAGAAATATAACATCTCTTCTTCAATTTCCCTGGGATT
GAGCTTCTGAGTAAAGGCCAAGGAGTTTCTGTGCCTGGTATTAACCCTCCCTCCCCAAGAACCC
CCACGAAGAGAGGAAATTTCCCAAGACTATTAAGACAGACTGAATTTGGGAAGGAAGTTTGGGG
AGGAGGGAGGCATGTAAATAACCTTGCAAGGGGTCTAAGAGCTCTCTGGTAGGCATTAGAGCTT
GGGGTGGGGCAGAATATGGCAAAATGAAATGGTGTCATAAAAGTGGAGGGGTGTTTGGATAAAA
TAAAATTACTGGAAAGAGTGAA

hide sequence

RefSeq Acc Id:

XM_040283504 ⟹ XP_040139438

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	63,011,700 - 63,045,710 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005340746	(Get FASTA)	NCBI Sequence Viewer
	XP_013220830	(Get FASTA)	NCBI Sequence Viewer
	XP_021576158	(Get FASTA)	NCBI Sequence Viewer
	XP_040139438	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004260.2
	ENSSTOP00000025463.1
GenBank Protein	KAG3272604	(Get FASTA)	NCBI Sequence Viewer
	KAG3272605	(Get FASTA)	NCBI Sequence Viewer
	KAG3272606	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_013220830 ⟸ XM_013365376
- Peptide Label:	isoform X2
- UniProtKB:	I3M4T4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTMHKLSYYEYDFERGRRGSKKGSIDVEKITCV ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL KNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTP EEDQILKKPLPPEPTAAPVSPGELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD KNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF AKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQKNKNA PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKV MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS KSDIWAFGVLMWEIYSLGKMPYERFNNSETAEHIAKGLRLYRPHLASERVYTIMYSCWHEKADE RPTFKILLSNILDVMDEES hide sequence

RefSeq Acc Id:	XP_005340746 ⟸ XM_005340689
- Peptide Label:	isoform X2
- UniProtKB:	I3M4T4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTMHKLSYYEYDFERGRRGSKKGSIDVEKITCV ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL KNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTP EEDQILKKPLPPEPTAAPVSPGELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD KNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF AKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQKNKNA PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKV MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS KSDIWAFGVLMWEIYSLGKMPYERFNNSETAEHIAKGLRLYRPHLASERVYTIMYSCWHEKADE RPTFKILLSNILDVMDEES hide sequence

RefSeq Acc Id:

XP_021576158 ⟸ XM_021720483

- Peptide Label:

isoform X1

- Sequence:

show sequence

MQWNLKNFHYQQHTSEPQKEEVMAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTMHKLSYYEY
DFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVY
DEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN
RNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPVSPGELKKVVALYDYMPMNANDLQ
LRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQE
GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYH
QHNSAGLISRLKYPVSQKNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD
VAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR
HRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS
VGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFNNSETAEHIAKGLRLYR
PHLASERVYTIMYSCWHEKADERPTFKILLSNILDVMDEES

hide sequence

RefSeq Acc Id:	XP_040139438 ⟸ XM_040283504
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSSTOP00000025463 ⟸ ENSSTOT00000043134

Ensembl Acc Id:

ENSSTOP00000004260 ⟸ ENSSTOT00000004745

Protein Domains

PH Protein kinase SH2 SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004722	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004745.3	UniProtKB/TrEMBL
	ENSSTOT00000043134.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	BTK_SH3	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
NCBI Gene	Btk	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TECBTKDOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
SMART	BTK	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A287CW11_ICTTR	UniProtKB/TrEMBL
	I3M4T4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)