Bak1 (BCL2 antagonist/killer 1) - Rat Genome Database

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Pathways
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Gene: Bak1 (BCL2 antagonist/killer 1) Ictidomys tridecemlineatus
Analyze
Symbol: Bak1
Name: BCL2 antagonist/killer 1
RGD ID: 12705301
Description: ENCODES a protein that exhibits BH domain binding (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); endocrine pancreas development (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); ataxia telangiectasia (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2 homologous antagonist/killer
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process  (IEA)
apoptotic process involved in blood vessel morphogenesis  (IEA)
apoptotic signaling pathway  (IEA)
B cell apoptotic process  (IEA)
B cell homeostasis  (IEA)
B cell negative selection  (IEA)
blood vessel remodeling  (IEA)
calcium ion transport into cytosol  (IEA)
cellular response to mechanical stimulus  (IEA)
cellular response to UV  (IEA)
endocrine pancreas development  (ISO)
epithelial cell proliferation  (IEA)
establishment of localization in cell  (IEA)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
fibroblast apoptotic process  (IEA)
homeostasis of number of cells  (IEA)
intrinsic apoptotic signaling pathway  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA)
leukocyte homeostasis  (IEA)
limb morphogenesis  (IEA)
mitochondrial fusion  (IEA)
myeloid cell homeostasis  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
peptidyl-serine phosphorylation  (ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of calcium ion transport into cytosol  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (ISO)
post-embryonic camera-type eye morphogenesis  (IEA)
regulation of apoptotic process  (IEA)
regulation of cell cycle  (IEA)
regulation of mitochondrial membrane permeability  (IEA)
regulation of mitochondrial membrane potential  (IEA)
release of cytochrome c from mitochondria  (IEA,ISO)
response to ethanol  (ISO)
response to fungus  (IEA)
response to gamma radiation  (IEA)
response to hydrogen peroxide  (ISO)
response to mycotoxin  (IEA)
response to UV-C  (ISO)
response to xenobiotic stimulus  (ISO)
thymocyte apoptotic process  (IEA)
transmembrane transport  (IEA)
vagina development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,572,552 - 33,580,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,572,547 - 33,580,293 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,540,329 - 33,548,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
T2T-CHM13v2.0633,393,742 - 33,401,466 (-)NCBIT2T-CHM13v2.0
Bak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)EnsemblGRCm39 Ensembl
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBIMGSCv36mm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.65NCBI
Bak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,102,334 - 5,111,615 (-)NCBIGRCr8
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,826,258 - 5,834,812 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,188,000 - 5,196,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,666,112 - 5,674,701 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Celera206,681,267 - 6,689,805 (-)NCBICelera
Cytogenetic Map20p12NCBI
Bak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,036,415 - 2,041,997 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,036,415 - 2,041,997 (-)NCBIChiLan1.0ChiLan1.0
BAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,255,769 - 34,263,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)Ensemblpanpan1.1panPan2
BAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,950,359 - 2,957,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,948,364 - 2,957,018 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,967,686 - 2,970,924 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,282,315 - 3,289,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,280,333 - 3,289,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,950,651 - 2,953,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,031,622 - 3,034,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,129,752 - 3,132,990 (-)NCBIUU_Cfam_GSD_1.0
BAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,808,849 - 29,815,318 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,808,849 - 29,815,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,279,191 - 34,286,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,492,776 - 38,502,534 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,492,858 - 38,501,281 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,412,290 - 33,419,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000002487   ⟹   ENSSTOP00000002224
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,353,227 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000033633   ⟹   ENSSTOP00000029333
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)Ensembl
RefSeq Acc Id: XM_005318805   ⟹   XP_005318862
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494638,605,488 - 38,612,701 (-)NCBI
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040282485   ⟹   XP_040138419
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005318862 (Get FASTA)   NCBI Sequence Viewer  
  XP_040138419 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002224.3
  ENSSTOP00000029333.1
GenBank Protein KAG3289241 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005318862   ⟸   XM_005318805
- Peptide Label: isoform X2
- UniProtKB: A0A287D718 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040138419   ⟸   XM_040282485
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000029333   ⟸   ENSSTOT00000033633
Ensembl Acc Id: ENSSTOP00000002224   ⟸   ENSSTOT00000002487
Protein Domains
Bcl-2 Bcl-2 homology region 1-3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002492 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002487.3 UniProtKB/TrEMBL
  ENSSTOT00000033633.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
NCBI Gene Bak1 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF41 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
PRINTS BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A0A287D718 ENTREZGENE, UniProtKB/TrEMBL
  I3M0I4_ICTTR UniProtKB/TrEMBL