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Gene: Alox15 (arachidonate 15-lipoxygenase) Ictidomys tridecemlineatus

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Symbol:

Alox15

Name:

arachidonate 15-lipoxygenase

RGD ID:

12704380

Description:

ENCODES a protein that exhibits arachidonate 12(S)-lipoxygenase activity (ortholog); arachidonate 15-lipoxygenase activity (ortholog); hepoxilin-epoxide hydrolase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); fatty acid oxidation (ortholog); hepoxilin biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); asthma (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

polyunsaturated fatty acid lipoxygenase ALOX15

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	52,659,633 - 52,689,018 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936677	3,232,183 - 3,241,253 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936677	3,232,183 - 3,241,307 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

Alzheimer's disease (ISO)

asthma (ISO)

asthma, nasal polyps, and aspirin intolerance (ISO)

atherosclerosis (ISO)

autism spectrum disorder (ISO)

brain ischemia (ISO)

congestive heart failure (ISO)

diabetic neuropathy (ISO)

diastolic heart failure (ISO)

Esophageal Neoplasms (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

glomerulonephritis (ISO)

hypertension (ISO)

Inflammation (ISO)

Insulin Resistance (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Nasal Polyps (ISO)

peritonitis (ISO)

Reperfusion Injury (ISO)

type 1 diabetes mellitus (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic cell clearance (IEA)

arachidonate metabolic process (IEA,ISO)

bone mineralization (IEA)

cellular response to calcium ion (IEA)

cellular response to interleukin-13 (IEA)

fatty acid metabolic process (IEA)

fatty acid oxidation (ISO)

hepoxilin biosynthetic process (ISO)

linoleic acid metabolic process (IEA,ISO)

lipid metabolic process (IEA)

lipid oxidation (IEA)

lipoxin A4 biosynthetic process (IEA)

lipoxygenase pathway (IEA,ISO)

negative regulation of adaptive immune response (IEA)

ossification (IEA)

phosphatidylethanolamine biosynthetic process (IEA)

positive regulation of actin filament polymerization (IEA)

positive regulation of cell-substrate adhesion (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of heterotypic cell-cell adhesion (ISO)

regulation of engulfment of apoptotic cell (IEA)

regulation of inflammatory response (IEA)

regulation of peroxisome proliferator activated receptor signaling pathway (IEA)

response to endoplasmic reticulum stress (IEA)

wound healing (IEA)

Cellular Component

cytoplasm (IEA)

cytoplasmic side of plasma membrane (IEA)

cytosol (IEA)

lipid droplet (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

arachidonate 12(S)-lipoxygenase activity (IEA,ISO)

arachidonate 15-lipoxygenase activity (IEA,ISO)

dioxygenase activity (IEA)

hepoxilin-epoxide hydrolase activity (ISO)

hydroperoxy icosatetraenoate isomerase activity (ISO)

iron ion binding (IEA)

linoleate 13S-lipoxygenase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

atherosclerosis pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

interleukin-4 signaling pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

type 1 diabetes mellitus pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Alox15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	52,659,633 - 52,689,018 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936677	3,232,183 - 3,241,253 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936677	3,232,183 - 3,241,307 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALOX15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	4,630,919 - 4,641,678 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	4,630,919 - 4,642,294 (-)	Ensembl			hg38	GRCh38
GRCh37	17	4,534,214 - 4,544,973 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	4,480,963 - 4,491,709 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	4,480,964 - 4,491,709	NCBI
Celera	17	4,546,922 - 4,554,338 (-)	NCBI		Celera
Cytogenetic Map	17	p13.2	NCBI
HuRef	17	4,423,571 - 4,434,147 (-)	NCBI		HuRef
CHM1_1	17	4,542,997 - 4,553,746 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	4,520,655 - 4,531,416 (-)	NCBI		T2T-CHM13v2.0

Alox15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	70,234,973 - 70,279,465 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	70,234,978 - 70,242,857 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	70,344,147 - 70,390,538 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	70,344,152 - 70,352,031 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	70,157,649 - 70,165,533 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	70,160,348 - 70,168,210 (-)	NCBI		MGSCv36	mm8
Celera	11	77,888,721 - 77,896,673 (-)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.99	NCBI

Alox15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	55,559,060 - 55,567,535 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	55,559,061 - 55,567,723 (-)	Ensembl				GRCr8
mRatBN7.2	10	55,060,169 - 55,068,885 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	55,060,412 - 55,068,874 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	59,739,979 - 59,748,431 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	59,228,481 - 59,236,931 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,727,685 - 54,736,135 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,953,692 - 56,962,145 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,953,691 - 56,962,161 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	56,704,488 - 56,713,186 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	57,185,939 - 57,194,388 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	54,211,640 - 54,220,083 (-)	NCBI		Celera
RGSC_v3.1	10	57,199,562 - 57,208,011 (-)	NCBI
Cytogenetic Map	10	q24	NCBI

Alox15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	10,032,792 - 10,039,323 (-)	Ensembl
ChiLan1.0	NW_004955467	10,032,792 - 10,039,789 (-)	NCBI	ChiLan1.0	ChiLan1.0

ALOX15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	12,246,447 - 12,258,698 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	14,214,750 - 14,226,986 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	4,686,339 - 4,696,877 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	4,677,125 - 4,687,669 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	4,677,125 - 4,687,669 (-)	Ensembl			panPan2	panpan1.1

ALOX15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	31,883,544 - 31,891,357 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	31,882,501 - 32,038,119 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,022,707 - 32,030,999 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	31,988,523 - 31,996,819 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	31,988,497 - 31,996,890 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	31,954,788 - 31,963,077 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	31,914,466 - 31,922,749 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,090,734 - 32,099,028 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

ALOX15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,287,160 - 52,295,871 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	52,287,174 - 52,295,873 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	54,502,074 - 54,510,831 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALOX15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	4,112,795 - 4,121,764 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	4,111,151 - 4,121,645 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666059	17,518,868 - 17,530,240 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040269471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000023746 ⟹ ENSSTOP00000019870

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936677	3,232,183 - 3,241,253 (+)	Ensembl

RefSeq Acc Id:

XM_005337382 ⟹ XP_005337439

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	52,659,633 - 52,669,236 (-)	NCBI
SpeTri2.0	NW_004936677	3,232,183 - 3,241,307 (+)	NCBI

Sequence:

show sequence

TGGAGACAAGCCACTGACGACCCGACTTCCGAGAGGGCGGGGTCTCGGGCTCTATTATTTAATG
CTTCCACCCTTCTTCATCCTCAGAACCCGTTAAGCGGCTTTGAGCAAGATGGGTGTCTATCGCG
TCCGCGTGTCCACTGGTTCCTCTCTCTACGCGGGCTCCGCTAACCACGTGCAGCTGTGGTTGGT
CGGCCAGCACGGGGAGGCAGCGCTCGGCGTGCTGCTAAGGCCAGCCAGAGACCAGGAACAGGAG
TTCAAGGTGGAAGTCTCAGAGTACTTGGGGTCCCTGCTGTTTGTGAAAGTGCGCAAAAGGCACC
TCATTAAGGATGACAACTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCTGGAGGTGGAGGGCC
TGAGTACAGGTTCCCTTGTTACCGTTGGGTGCAGGGCAACCACATCTTGAGCCTTGCTGAGGGC
ACTGGCTGCACAGTTGTTGAAGACTCTCAAGGACTTTTCAAGAAGCACAGGGAAGAGGAACTGG
AAGAGAGAAGGAAGTTGTACAAGTGGGGTAACTGGAAGGCTGGCTTAGTTCTGAATGTGGCTGG
GACTAGTTTATCTGACCTCCCTGAAGATGAGCGATTTCTGGAAAACAAGAGAGTTGACTTTGAA
GGTTCACTGGCCGTAGGGCTGGCTGACCTGGCTGTCAAAAGATCTGTGAATATTCTGAGTAACT
GGAATGATGTGGATGACTATAACCGGATTTTTTGGTGTGGCTACAGCAAGCTGGCTGAGCGAGT
GCGGCAGTCCTGGAAGGAGGATGCCTTCTTTGGGTATCAGTTTCTCAATGGTGCCAACCCCATG
CTGCTGAGGCGCTCCACTCAGCTTCCTGAACGCCTAGTGTTTCCTCCAGGGATGGAGGAACTGC
AGGCTCAGTTGCAGAAGGAGCTCAAGGAAGGCACCTTGTTTGAAGCTGATTTTTACCTACTTGA
TGGGATCAAGGCCAATGTCATCTGTAATCACCAACAGCACCTGGCTGCCCCTCTGGTCATGCTG
AAGCTGCAGCCTGATGGGCAACTCTTACCCATGGTCATTCAGCTCCAACTGCCAAAGATCGGAT
CTATTCCGCCACCCCTTTTCCTGCCCACGGATCCCCCAGTGGTCTGGCTCTTGGCCAAATGCTG
GGTCCGTAGCTCTGAATTCCAGCTTCATGAGCTGCAGTCTCATCTTCTGAGAGGACATTTGATG
GCTGAGGTCTTTGCTGTGGCCACCATGAGGTGCCTTCCATCAGTACATCCTGTCTTCAAGCTTA
TAGTTCCTCACCTTCGATACACCATGGAAATTAACCTTCGGGCCAGGAATGGGCTGGTCTCAGA
CTGTGGAATTTTTGACCAGGTGGTGAGCATAGGTGGGGGAGGCCACCTGGATCTGCTGAGGCGT
GCTGGAGGTCTTCTGACCTATAGCTCATTATGTCCCCCTGACGACTTAGCTGACCGGGGGCTCC
TGGAAGTCAAGTCTTCCTACTATGCTCAAGATGCACTGCGGCTCTGGGAAATCATCCGTCGGTA
TGTGGAAGGAATTATGGATCTGTACTATAAGACAGATGTGGCTGTGAGAGATGACCCTGAGCTG
CAGAACTGGTGTCGAGAGATCACTGAAATTGGGCTGCTAGGGGCCCAGGACCGAGGGTTTCCCA
CCTCTCTCCAGTCTCGGGCCCAGGCTTGCCACTTTGTCACCATGTGCATCTTCACCTGCACTGG
GCAGCACTCTTCCATCCACCTGGGCCAGTTGGATTGGTTCTCTTGGATCCCTAATGCACCCTGC
ACCATGCGGCTGCCCCCACCAACTACCAAGGATGCCACTATGGAGACAGTGATGGCCACACTGC
CCACTGTTAATCAGGCTACTCTCCAGATGTCCATCATTTGGCAACTTGGCAGACGCCAGCCCGT
TATGGTGCCTCTGGGCCAGCATGAGGAGGAGTATTTTTCAACTCCTGGGCCCAAGGCTGTGCTG
AAGAGGTTCAGGGAGGAGCTGGCTGTCCTGGACAAGGAAATCGAGGTCCGGAATGAAAACCTAA
ACATACCCTATGAGTACCTGCGACCCAGCCTGGTGGAAAATAGTGTGGCCATATGAGTGTCCCA
AGCTTTTGGTTGTTTTAGCTCTCCTCCGCCCAAACCACAGCCACCCTTCCCAAATGTGACCTTT
CCCTTGTCTCTGCCCCTTGGAACACATTTCATTTTAGATGCGTCATCTAGGTGCCTCTATTCTT
TCCTCTTTTCCTCCCTCCCTCTCTTCTTTGCTTACCATTCAGATTTCCTCTAGGGCCAATAATA
GCCACCTTTTACAAACTATTTCAAGAATATGATAGAGTGATAGCATATATTGCACGACATCTTT
TAGGAATTGAATTTGATTTTGAACCTAAATTTTAATAACAGCAAAACATGTTTTACACTAGTGA
TAGAAAAGAGCTTACACCCAG

hide sequence

RefSeq Acc Id:

XM_040269471 ⟹ XP_040125405

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	52,659,633 - 52,689,018 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005337439	(Get FASTA)	NCBI Sequence Viewer
	XP_040125405	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000019870.2
GenBank Protein	KAG3270025	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005337439 ⟸ XM_005337382
- Peptide Label:	isoform X1
- UniProtKB:	I3N674 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVYRVRVSTGSSLYAGSANHVQLWLVGQHGEAALGVLLRPARDQEQEFKVEVSEYLGSLLFVK VRKRHLIKDDNWFCNWISVQGPGGGGPEYRFPCYRWVQGNHILSLAEGTGCTVVEDSQGLFKKH REEELEERRKLYKWGNWKAGLVLNVAGTSLSDLPEDERFLENKRVDFEGSLAVGLADLAVKRSV NILSNWNDVDDYNRIFWCGYSKLAERVRQSWKEDAFFGYQFLNGANPMLLRRSTQLPERLVFPP GMEELQAQLQKELKEGTLFEADFYLLDGIKANVICNHQQHLAAPLVMLKLQPDGQLLPMVIQLQ LPKIGSIPPPLFLPTDPPVVWLLAKCWVRSSEFQLHELQSHLLRGHLMAEVFAVATMRCLPSVH PVFKLIVPHLRYTMEINLRARNGLVSDCGIFDQVVSIGGGGHLDLLRRAGGLLTYSSLCPPDDL ADRGLLEVKSSYYAQDALRLWEIIRRYVEGIMDLYYKTDVAVRDDPELQNWCREITEIGLLGAQ DRGFPTSLQSRAQACHFVTMCIFTCTGQHSSIHLGQLDWFSWIPNAPCTMRLPPPTTKDATMET VMATLPTVNQATLQMSIIWQLGRRQPVMVPLGQHEEEYFSTPGPKAVLKRFREELAVLDKEIEV RNENLNIPYEYLRPSLVENSVAI hide sequence

RefSeq Acc Id:	XP_040125405 ⟸ XM_040269471
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000019870 ⟸ ENSSTOT00000023746

Protein Domains

Lipoxygenase PLAT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024123	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023746.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.60	UniProtKB/TrEMBL
	Lipoxygenase-1, Domain 5	UniProtKB/TrEMBL
	PLAT/LH2 domain	UniProtKB/TrEMBL
InterPro	LipOase	UniProtKB/TrEMBL
	LipOase_C	UniProtKB/TrEMBL
	LipOase_C_sf	UniProtKB/TrEMBL
	LipOase_CS	UniProtKB/TrEMBL
	LipOase_Fe_BS	UniProtKB/TrEMBL
	LipOase_mml	UniProtKB/TrEMBL
	PLAT/LH2_dom	UniProtKB/TrEMBL
	PLAT/LH2_dom_sf	UniProtKB/TrEMBL
	PLAT_LOX_verte	UniProtKB/TrEMBL
KEGG Report	iti:101973674	UniProtKB/TrEMBL
NCBI Gene	Alox15	ENTREZGENE
PANTHER	PTHR11771	UniProtKB/TrEMBL
Pfam	Lipoxygenase	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
PRINTS	LIPOXYGENASE	UniProtKB/TrEMBL
	MAMLPOXGNASE	UniProtKB/TrEMBL
PROSITE	LIPOXYGENASE_1	UniProtKB/TrEMBL
	LIPOXYGENASE_2	UniProtKB/TrEMBL
	LIPOXYGENASE_3	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
SMART	LH2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48484	UniProtKB/TrEMBL
	SSF49723	UniProtKB/TrEMBL
UniProt	I3N674	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)