Cdkn1b<sup>em4Musc</sup> (cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc) - Rat Genome Database

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Gene: Cdkn1bem4Musc (cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc) Rattus norvegicus
Symbol: Cdkn1bem4Musc
Name: cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 4, Musc
RGD ID: 126928151
Description: The CRISPR/Cas9 system targeted to exon 2 of the rat Cdkn1b was injected to zygotes derived from the Sprague-Dawley outbred rat strain. This allele contains 65-bp deletion that disrupts the reading frame of the gene.
ASSOCIATED WITH abnormal mammary gland luminal epithelium morphology; cataract; increased body weight; ASSOCIATED WITH cataract; infertility
Type: allele  of Cdkn1b  
Previously known as: Cdkn1b^[em4Musc]
Is Marker For: Strains:   ACI.Cg.-Cdkn1bem4Musc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. Ding L, etal., PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar.


Related Rat Strains
The following Strains have been annotated to Cdkn1bem4Musc



Nucleotide Sequences

Additional Information