Cdkn1b<sup>em1Musc</sup> (cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc) - Rat Genome Database

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Gene: Cdkn1bem1Musc (cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc) Rattus norvegicus
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Symbol: Cdkn1bem1Musc
Name: cyclin-dependent kinase inhibitor 1B; CRISPR/Cas9 induced mutant 1, Musc
RGD ID: 126928147
Description: The CRISPR/Cas9 system targeted to exon 2 of the rat Cdkn1b was injected to zygotes derived from the Sprague-Dawley outbred rat strain. This allele contains 32-bp deletion that disrupts the reading frame of the gene.
ASSOCIATED WITH abnormal mammary gland luminal epithelium morphology; cataract; increased body weight; ASSOCIATED WITH cataract; infertility
Type: allele  of Cdkn1b  
Previously known as: Cdkn1b^[em1Musc]; DEL-32
Is Marker For: Strains:   ACI.Cg.-Cdkn1bem1Musc  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. Ding L, etal., PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar.
2. Personal Communication with Dr. Bart M. G. Smits Personal Communication with Dr. Bart M. G. Smits, PhD

Genomics


Related Rat Strains
The following Strains have been annotated to Cdkn1bem1Musc
ACI.Cg.-Cdkn1bem1Musc    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information