Cftr<sup>em2Ang</sup> (cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 2, Ang) - Rat Genome Database

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Gene: Cftrem2Ang (cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 2, Ang) Rattus norvegicus
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Symbol: Cftrem2Ang
Name: cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 2, Ang
RGD ID: 126925995
Description: The CRISPR/Cas9 system targeting at exon 3 to create gene knock out was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a frameshift and the creation of one XbaI restriction site and a premature stop codon.
ASSOCIATED WITH abnormal enamel development; abnormal olfactory epithelium physiology; absent vas deferens; ASSOCIATED WITH cystic fibrosis; dental enamel hypoplasia
Type: allele  of Cftr  
Previously known as: CFTR KO; Cftr^[em2Ang]
Is Marker For: Strains:   SD-Cftrem2Ang  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9. Dreano E, etal., Animal Model Exp Med. 2019 Nov 25;2(4):297-311. doi: 10.1002/ame2.12091. eCollection 2019 Dec.

Genomics


Related Rat Strains
The following Strains have been annotated to Cftrem2Ang


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-25 Cftrem2Ang  cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 2, Ang  Cftrem2Ang  cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 1, Ang  Name changed 629549 APPROVED