Cftr<sup>em1Ang</sup> (cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 1, Ang) - Rat Genome Database

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Gene: Cftrem1Ang (cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 1, Ang) Rattus norvegicus
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Symbol: Cftrem1Ang
Name: cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 1, Ang
RGD ID: 126925993
Description: The CRISPR/Cas9 system targeting at exon 12 to create deletion at codon F508 was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a codon deletion at F508 and the creation of one NdeI restriction site for sequencing identification.
ASSOCIATED WITH abnormal enamel development; abnormal olfactory epithelium physiology; decreased body weight; ASSOCIATED WITH cystic fibrosis; dental enamel hypoplasia
Type: allele  of Cftr  
Previously known as: Cftr^[em1Ang]
Is Marker For: Strains:   SD-Cftrem1Ang  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Characterization of two rat models of cystic fibrosis-KO and F508del CFTR-Generated by Crispr-Cas9. Dreano E, etal., Animal Model Exp Med. 2019 Nov 25;2(4):297-311. doi: 10.1002/ame2.12091. eCollection 2019 Dec.

Genomics


Related Rat Strains
The following Strains have been annotated to Cftrem1Ang


Expression


Sequence

Nucleotide Sequences


Additional Information