Myh7b<sup>em1Blar</sup> (myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar) - Rat Genome Database

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Gene: Myh7bem1Blar (myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar) Rattus norvegicus
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Symbol: Myh7bem1Blar
Name: myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
RGD ID: 126925953
Description: The Myh7b knockout allele was generated using the CRISPR/Cas9 system targeting exon 2 in SD embryos, resulting 7 bases deletion of exon 2 and generated a new termination codon TGA in exon 3.
ASSOCIATED WITH abnormal myocardial fiber calcium currents; abnormal sarcomere morphology; cardiac fibrosis; ASSOCIATED WITH hypertrophic cardiomyopathy
Type: allele  of Myh7b  
Previously known as: Myh7bem1Blar-/-; Myh7b^[em1Blar]
Is Marker For: Strains:   SD-Myh7bem1Blar-/-   SD-Myh7bem1Blar+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway. Chen P, etal., Sci China Life Sci. 2020 Sep;63(9):1347-1362. doi: 10.1007/s11427-019-1627-y. Epub 2020 Mar 17.

Genomics


Related Rat Strains
The following Strains have been annotated to Myh7bem1Blar


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-30 Myh7bem1Blar  myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar  Myh7bem1Blar-/-  myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar  Symbol changed 629549 APPROVED