Cryba1<sup>Nuc1Dbsa</sup> (crystallin, beta A1;Nuc1 mutant, Dbsa) - Rat Genome Database

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Gene: Cryba1Nuc1Dbsa (crystallin, beta A1;Nuc1 mutant, Dbsa) Rattus norvegicus
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Symbol: Cryba1Nuc1Dbsa
Name: crystallin, beta A1;Nuc1 mutant, Dbsa
RGD ID: 126925758
Description: This spontaneous mutation was identified in the offspring of pregnant Sprague-Dawley rats purchased from Taconic Farms. This mutant exhibited abnormal eye phenotype including nuclear cataracts and was called Nuc1 rat. Sequencing of the mutant allele revealed a 27 base pair insertion in exon 6 of Cryba1.
ASSOCIATED WITH abnormal astrocyte morphology; abnormal autophagy; abnormal retina ganglion layer morphology; ASSOCIATED WITH cataract; microphthalmia; Reticular Dystrophy of Retinal Pigment Epithelium
Type: allele  of Cryba1  
Is Marker For: Strains:   SD-Cryba1Nuc1Dbsa  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. A spontaneous mutation affects programmed cell death during development of the rat eye. Sinha D, etal., Exp Eye Res. 2005 Mar;80(3):323-35. doi: 10.1016/j.exer.2004.09.014.
2. betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Sinha D, etal., Mol Cell Neurosci. 2008 Jan;37(1):85-95. Epub 2007 Aug 31.
3. Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat. Zigler JS, etal., J Cell Sci. 2011 Feb 15;124(Pt 4):523-31. doi: 10.1242/jcs.078790. Epub 2011 Jan 25.

Genomics


Related Rat Strains
The following Strains have been annotated to Cryba1Nuc1Dbsa


Expression


Sequence

Nucleotide Sequences


Additional Information