Fmr1 (Fragile X messenger ribonucleoprotein 1) - Rat Genome Database

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Gene: Fmr1 (Fragile X messenger ribonucleoprotein 1) Ictidomys tridecemlineatus
Analyze
Symbol: Fmr1
Name: Fragile X messenger ribonucleoprotein 1
RGD ID: 12682124
Description: ENCODES a protein that exhibits chromatin binding (ortholog); dynein complex binding (ortholog); microtubule binding (ortholog); INVOLVED IN cellular response to L-glutamate (ortholog); cellular response to potassium ion (ortholog); central nervous system development (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); Cajal body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FMRP translational regulator 1; fragile X mental retardation 1; fragile X mental retardation 1, transcript variant X1; fragile X mental retardation 1, transcript variant X2; fragile X mental retardation 1, transcript variant X3; fragile X mental retardation 1, transcript variant X4; fragile X mental retardation 1, transcript variant X5; fragile X mental retardation 1, transcript variant X6; fragile X mental retardation 1, transcript variant X7; fragile X mental retardation 1, transcript variant X8; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; synaptic functional regulator FMR1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365131,289,558 - 1,327,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365131,290,038 - 1,327,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
cellular response to L-glutamate  (ISO)
cellular response to potassium ion  (ISO)
cellular response to virus  (IEA)
central nervous system development  (ISO)
dendritic spine development  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
DNA repair  (IEA)
evoked excitatory postsynaptic potential  (ISO)
excitatory chemical synaptic transmission  (ISO)
glutamate receptor signaling pathway  (ISO)
inhibitory chemical synaptic transmission  (ISO)
intracellular glutamate homeostasis  (ISO)
locomotory exploration behavior  (ISO)
membraneless organelle assembly  (IEA)
miRNA-mediated post-transcriptional gene silencing  (ISO)
modulation by host of viral RNA genome replication  (IEA)
mRNA export from nucleus  (IEA)
mRNA processing  (IEA)
mRNA transport  (IEA)
negative regulation of cytoplasmic translation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of long-term synaptic depression  (ISO)
negative regulation of miRNA-mediated gene silencing  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of protein processing  (ISO)
negative regulation of receptor internalization  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
negative regulation of translation  (IEA)
negative regulation of translational initiation  (ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
nervous system development  (IEA)
ovarian follicle development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intracellular transport of viral material  (IEA)
positive regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of miRNA-mediated gene silencing  (IEA)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (IEA)
positive regulation of synaptic transmission  (ISO)
positive regulation of translation  (IEA)
regulation of alternative mRNA splicing, via spliceosome  (IEA)
regulation of dendritic spine development  (IEA)
regulation of filopodium assembly  (IEA)
regulation of mRNA stability  (IEA)
regulation of neuronal action potential  (IEA,ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of translation  (IEA)
regulation of translation at postsynapse, modulating synaptic transmission  (ISO)
regulation of translation at presynapse, modulating synaptic transmission  (IEA)
response to activity  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to interleukin-17  (ISO)
response to light stimulus  (ISO)
RNA splicing  (IEA)
social behavior  (ISO)
stress granule assembly  (IEA)
transmission of nerve impulse  (ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Fmr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365131,289,558 - 1,327,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365131,290,038 - 1,327,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X147,911,919 - 147,951,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX147,911,919 - 147,951,125 (+)EnsemblGRCh38hg38GRCh38
GRCh37X146,993,437 - 147,032,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X146,801,201 - 146,840,303 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X146,699,054 - 146,738,157NCBI
CeleraX147,345,446 - 147,384,585 (+)NCBICelera
Cytogenetic MapXq27.3NCBI
HuRefX135,963,879 - 135,993,282 (+)NCBIHuRef
CHM1_1X146,904,323 - 146,943,501 (+)NCBICHM1_1
T2T-CHM13v2.0X146,176,547 - 146,215,797 (+)NCBIT2T-CHM13v2.0
Fmr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,722,144 - 67,761,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)EnsemblGRCm39 Ensembl
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBIMGSCv36mm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
Fmr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,284,857 - 152,322,686 (+)NCBIGRCr8
mRatBN7.2X147,240,239 - 147,278,057 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,240,301 - 147,278,050 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX149,444,285 - 149,482,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X152,978,628 - 153,016,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,519,276 - 150,557,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Cytogenetic MapXq37NCBI
Fmr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955498566,688 - 595,360 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955498566,741 - 594,837 (+)NCBIChiLan1.0ChiLan1.0
FMR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X147,227,441 - 147,266,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X147,231,048 - 147,269,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X147,366,713 - 147,405,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensemblpanpan1.1panPan2
FMR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X116,249,079 - 116,287,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX116,249,142 - 116,321,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX102,141,952 - 102,179,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X118,308,237 - 118,346,144 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX118,308,224 - 118,346,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X115,421,122 - 115,459,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X117,632,687 - 117,670,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X117,359,050 - 117,396,958 (+)NCBIUU_Cfam_GSD_1.0
FMR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX120,361,367 - 120,399,831 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X120,361,232 - 120,400,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X137,792,642 - 137,831,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX122,635,439 - 122,674,355 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606560,266,278 - 60,318,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624883645,449 - 682,292 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624883645,524 - 681,705 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003266   ⟹   ENSSTOP00000002918
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365131,293,327 - 1,318,710 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000039371   ⟹   ENSSTOP00000025824
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365131,289,558 - 1,327,856 (-)Ensembl
RefSeq Acc Id: XM_005325138   ⟹   XP_005325195
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,291,047 - 1,327,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005325140   ⟹   XP_005325197
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,291,054 - 1,327,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013358547   ⟹   XP_013214001
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,290,039 - 1,327,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013358549   ⟹   XP_013214003
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,290,039 - 1,327,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013358550   ⟹   XP_013214004
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,290,039 - 1,327,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013358551   ⟹   XP_013214005
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,290,039 - 1,327,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040286531   ⟹   XP_040142465
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,286,773 - 114,321,108 (+)NCBI
RefSeq Acc Id: XM_040286542   ⟹   XP_040142476
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X114,299,582 - 114,324,847 (+)NCBI
RefSeq Acc Id: XP_005325195   ⟸   XM_005325138
- Peptide Label: isoform X1
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL),   A0A287CX40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005325197   ⟸   XM_005325140
- Peptide Label: isoform X4
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013214005   ⟸   XM_013358551
- Peptide Label: isoform X7
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013214004   ⟸   XM_013358550
- Peptide Label: isoform X6
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013214001   ⟸   XM_013358547
- Peptide Label: isoform X2
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013214003   ⟸   XM_013358549
- Peptide Label: isoform X3
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040142465   ⟸   XM_040286531
- Peptide Label: isoform X5
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040142476   ⟸   XM_040286542
- Peptide Label: isoform X8
- UniProtKB: I3M1Y9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000002918   ⟸   ENSSTOT00000003266
Ensembl Acc Id: ENSSTOP00000025824   ⟸   ENSSTOT00000039371
Protein Domains
Agenet-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003260 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003266.3 UniProtKB/TrEMBL
  ENSSTOT00000039371.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/TrEMBL
InterPro Agenet-like_dom UniProtKB/TrEMBL
  FMR1 UniProtKB/TrEMBL
  FMRP_KH0 UniProtKB/TrEMBL
  FXMR_C2 UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/TrEMBL
  KH_dom UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  KH_I_FMR1_rpt1 UniProtKB/TrEMBL
  KH_I_FMR1_rpt2 UniProtKB/TrEMBL
  Tudor_Agenet_FMR1_rpt1 UniProtKB/TrEMBL
  Tudor_Agenet_FMR1_rpt2 UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/TrEMBL
NCBI Gene Fmr1 ENTREZGENE
PANTHER PTHR10603 UniProtKB/TrEMBL
  SYNAPTIC FUNCTIONAL REGULATOR FMR1 UniProtKB/TrEMBL
Pfam Agenet UniProtKB/TrEMBL
  FXMR_C2 UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/TrEMBL
  KH_1 UniProtKB/TrEMBL
  KH_9 UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/TrEMBL
PROSITE AGENET_LIKE UniProtKB/TrEMBL
  KH_TYPE_1 UniProtKB/TrEMBL
SMART SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
UniProt A0A287CX40 ENTREZGENE, UniProtKB/TrEMBL
  I3M1Y9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-05 Fmr1  Fragile X messenger ribonucleoprotein 1  Fmr1  FMRP translational regulator 1  Symbol and/or name change 5135510 APPROVED
2019-08-27 Fmr1  FMRP translational regulator 1  Fmr1  fragile X mental retardation 1  Symbol and/or name change 5135510 APPROVED