Ahr<sup>em2Sage</sup> (aryl hydrocarbon receptor; ZFN induced mutant2, Sage) - Rat Genome Database

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Gene: Ahrem2Sage (aryl hydrocarbon receptor; ZFN induced mutant2, Sage) Rattus norvegicus
Symbol: Ahrem2Sage
Name: aryl hydrocarbon receptor; ZFN induced mutant2, Sage
RGD ID: 126790510
Description: ZFN constructs were designed to target exon 2 which contains the DNA binding bHLH motif of the AHR gene. The ZFN system was injected to embryos from outbred Sprague Dawle from Harlan and one founder contained a 29-bp deletion in the rat Ahr gene. The deletion resulted in a premature stop codon within exon 2.
ASSOCIATED WITH abnormal kidney medullary ray morphology; abnormal urothelium morphology; absent ductus venosus
Type: allele  of Ahr  
Is Marker For: Strains:   SD-Ahrem2Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Harrill JA, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.
2. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.


Related Rat Strains
The following Strains have been annotated to Ahrem2Sage



Nucleotide Sequences

Additional Information