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Gene: Csf1r^tm(EGFP)Tset (colony stimulating factor 1 receptor; target mutant, Tset) Rattus norvegicus

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Symbol:	Csf1r^tm(EGFP)Tset
Name:	colony stimulating factor 1 receptor; target mutant, Tset
RGD ID:	126781692
Description:	Targeting vector was designed to disrupt the first exon encoding of Csf1r gene with a drug selection cassette by homologous recombination in Rat ESC clone DAK31-C2. Sprague-Dawley females were used as embryo donors and pseudo-pregnant recipients. ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH bone development disease; infertility; lymphopenia
Type:	allele of Csf1r
Previously known as:	Csf1r^[tm(EGFP)Tset]
Is Marker For:	Strains: SD-Csf1r^tm(EGFP)-/-/Tset DA-Csf1r^tm(EGFP)-/-/Hume SD-Csf1r^tm(EGFP)+/-/Tset DA-Csf1r^tm(EGFP)+/-/Hume
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bone development disease (IMP)

infertility (IMP)

lymphopenia (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal brain development (IMP)

abnormal corpus callosum size (IMP)

absent teeth (IMP)

decreased anterior commissure size (IMP)

decreased body weight (IMP)

decreased circulating alanine transaminase level (IMP)

decreased circulating calcium level (IMP)

decreased circulating phosphate level (IMP)

decreased corpora lutea number (IMP)

decreased dentate gyrus size (IMP)

decreased hippocampal commissure size (IMP)

decreased hippocampal fornix size (IMP)

decreased Langerhans cell number (IMP)

decreased macrophage cell number (IMP)

decreased microglial cell number (IMP)

decreased monocyte cell number (IMP)

decreased osteoclast cell number (IMP)

decreased white adipose tissue amount (IMP)

enlarged brain ventricles (IMP)

increased granulocyte number (IMP)

microdontia (IMP)

postnatal growth retardation (IMP)

premature death (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations.	Patkar OL, etal., Neurobiol Dis. 2021 Apr;151:105268. doi: 10.1016/j.nbd.2021.105268. Epub 2021 Jan 12.
2.	Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.	Pridans C, etal., J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24.

Genomics

Related Rat Strains

The following Strains have been annotated to Csf1r^tm(EGFP)Tset

DA-Csf1r^tm(EGFP)+/-/Hume DA-Csf1r^tm(EGFP)-/-/Hume SD-Csf1r^tm(EGFP)+/-/Tset SD-Csf1r^tm(EGFP)-/-/Tset

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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Mammalian Phenotype