Mkx<sup>em1Asah</sup> (mohawk homeobox; CRISPR/Cas9 system induced mutant 1, Asah)

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Gene: Mkx^em1Asah (mohawk homeobox; CRISPR/Cas9 system induced mutant 1, Asah) Rattus norvegicus

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Symbol:	Mkx^em1Asah
Name:	mohawk homeobox; CRISPR/Cas9 system induced mutant 1, Asah
RGD ID:	126777685
Description:	The CRISPR/Cas9 genome editing system targeting exon 2 of rat Mkx gene was injected to the Wistar embryo to generate this knock out allele with 14- bp deletion causing frameshift mutation in the gene. ASSOCIATED WITH abnormal gait; abnormal tendon collagen fibril morphology; abnormal tendon morphology; ASSOCIATED WITH Heterotopic Ossification
Type:	allele of Mkx
Is Marker For:	Strains: WI-Mkx^em1Asah
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Heterotopic Ossification (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal gait (IMP)

abnormal tendon collagen fibril morphology (IMP)

abnormal tendon morphology (IMP)

decreased tendon stiffness (IMP)

increased bone ossification (IMP)

wavy tail (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.	Suzuki H, etal., Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1.

Genomics

Related Rat Strains

The following Strains have been annotated to Mkx^em1Asah

WI-Mkx^em1Asah

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype