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Gene: Sting1 (stimulator of interferon response cGAMP interactor 1) Ictidomys tridecemlineatus

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Symbol:

Sting1

Name:

stimulator of interferon response cGAMP interactor 1

RGD ID:

12663976

Description:

ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (inferred); cyclic-di-GMP binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); defense response to virus (ortholog); obsolete cellular response to organic cyclic compound (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); autosomal dominant intellectual developmental disorder 31 (ortholog); brucellosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); endoplasmic reticulum-Golgi intermediate compartment membrane (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Tmem173; transmembrane protein 173

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,048,662 - 153,055,631 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,555,637 - 8,562,885 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,555,966 - 8,562,829 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Toxoplasmosis (ISO)

autosomal dominant intellectual developmental disorder 31 (ISO)

brucellosis (ISO)

Chediak-Higashi syndrome (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chilblain Lupus 1 (ISO)

Chronic Hepatitis B (ISO)

chronic obstructive pulmonary disease (ISO)

Cytomegalovirus Infections (ISO)

esophagus squamous cell carcinoma (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Haemophilus Infections (ISO)

hepatitis B (ISO)

Hereditary Neoplastic Syndromes (ISO)

human immunodeficiency virus infectious disease (ISO)

listeriosis (ISO)

lymphadenitis (ISO)

Neurodevelopmental Disorders (ISO)

Pneumococcal Pneumonia (ISO)

schistosomiasis (ISO)

Silicotuberculosis (ISO)

STING-associated vasculopathy with onset in infancy (ISO)

tuberculosis (ISO)

West Nile encephalitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (IEA)

antiviral innate immune response (IEA)

autophagosome assembly (IEA)

cellular response to exogenous dsRNA (IEA)

cellular response to interferon-beta (IEA,ISO)

cGAS/STING signaling pathway (IEA)

cytoplasmic pattern recognition receptor signaling pathway (IEA)

defense response to virus (IEA,ISO)

innate immune response (IEA)

obsolete cellular response to organic cyclic compound (ISO)

pattern recognition receptor signaling pathway (IEA)

positive regulation of defense response to virus by host (IEA)

positive regulation of DNA-binding transcription factor activity (ISO)

positive regulation of interferon-beta production (IEA)

positive regulation of macroautophagy (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of type I interferon production (IEA)

positive regulation of type I interferon-mediated signaling pathway (IEA)

protein complex oligomerization (IEA,ISO)

protein localization to endoplasmic reticulum (IEA)

proton transmembrane transport (IEA)

regulation of gene expression (IEA,ISO)

regulation of inflammatory response (IEA,ISO)

regulation of metabolic process (IEA,ISO)

reticulophagy (IEA)

Cellular Component

autophagosome (IEA)

autophagosome membrane (IEA)

ciliary basal body (IEA)

cilium (IEA)

cytoplasm (IEA)

cytosol (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA,ISO)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA,ISO)

endosome (IEA)

Golgi apparatus (IEA)

Golgi membrane (IEA,ISO)

membrane (IEA)

mitochondrial outer membrane (IEA)

nucleoplasm (IEA)

perinuclear region of cytoplasm (IEA)

peroxisome (IEA)

STING complex (IEA)

Molecular Function

2',3'-cyclic GMP-AMP binding (IEA)

cyclic-di-GMP binding (IEA)

identical protein binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

protein kinase binding (IEA)

proton channel activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

signaling adaptor activity (IEA)

ubiquitin protein ligase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sting1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,048,662 - 153,055,631 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,555,637 - 8,562,885 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,555,966 - 8,562,829 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STING1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	139,475,533 - 139,482,758 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	139,475,533 - 139,482,935 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	138,855,118 - 138,862,343 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	138,835,733 - 138,842,476 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	134,930,158 - 134,937,391 (-)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	133,997,951 - 134,005,182 (-)	NCBI		HuRef
CHM1_1	5	138,287,678 - 138,294,915 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	140,000,594 - 140,007,823 (-)	NCBI		T2T-CHM13v2.0

Sting1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	35,866,731 - 35,873,607 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	35,866,732 - 35,873,607 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	35,733,678 - 35,740,554 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	35,733,679 - 35,740,554 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	35,893,332 - 35,900,208 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	35,859,652 - 35,866,528 (-)	NCBI		MGSCv36	mm8
Celera	18	36,189,779 - 36,196,655 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.23	NCBI

Sting1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	27,606,196 - 27,612,544 (-)	NCBI		GRCr8
mRatBN7.2	18	27,332,119 - 27,338,371 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	27,332,119 - 27,338,335 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	27,459,541 - 27,465,793 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	28,221,584 - 28,227,830 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	27,556,463 - 27,562,709 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	28,529,537 - 28,535,828 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	28,529,576 - 28,535,828 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	28,242,119 - 28,248,371 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	28,355,029 - 28,357,171 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	27,065,352 - 27,071,596 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

Sting1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	1,083,613 - 1,100,448 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	1,091,022 - 1,097,064 (+)	NCBI	ChiLan1.0	ChiLan1.0

STING1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	134,741,514 - 134,750,786 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	132,881,061 - 132,890,364 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	134,845,689 - 134,852,938 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	140,967,399 - 140,989,653 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	140,967,399 - 140,973,846 (-)	Ensembl	panpan1.1		panPan2

STING1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	34,783,947 - 34,792,204 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	34,784,232 - 34,789,072 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	31,886,015 - 31,894,282 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	35,237,857 - 35,246,124 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	35,217,688 - 35,243,000 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	32,290,300 - 32,298,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	33,156,814 - 33,165,081 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	33,908,726 - 33,916,993 (-)	NCBI		UU_Cfam_GSD_1.0

STING1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	141,358,993 - 141,367,198 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	141,359,402 - 141,367,222 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	147,169,469 - 147,177,263 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STING1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	42,153,576 - 42,160,903 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	42,153,026 - 42,160,907 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	35,727,193 - 35,734,956 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sting1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	32,273,385 - 32,283,235 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	32,277,197 - 32,283,346 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005327275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000028461 ⟹ ENSSTOP00000017977

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936531	8,555,637 - 8,562,885 (-)	Ensembl

RefSeq Acc Id:

XM_005327275 ⟹ XP_005327332

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	153,048,662 - 153,055,631 (+)	NCBI
SpeTri2.0	NW_004936531	8,555,966 - 8,562,829 (-)	NCBI

Sequence:

show sequence

AGGATCTACAACTGGAAATCTGCTTTAAACAATTAACCAGCAATACGTGTGTCGCCTTTGGCCC
TTGTGTGGAGTCCTGCTGGGTGTTTTGGATCCTGGGGACTTGAGAGGAACCTGGTGTACAGGGT
TGTGGCTACAGGCTGTACCCAGACAGGTTTCATTGGCTGCTGGTAGTCGCTGTGCCTGCGCTTC
AACGTCCGACATCTACCAGAAAGGACCTGTGTGTAAGAGGCAGAAGATGCCATGCTCCAGACTG
CATCCATCCATCCCATATCCCAGGGGTCACCGGGCCCAGCAGATGGCCTTGATCCTGCTGGGGG
CCTGCCTGGTGGCCCTTTGGGGACTTGGAAATTCTCCAGACCATACTCTTCAGTACCTGGTATT
CTACTTAGCCTCTCTGCAGTTGGGACTGCTGTTAAAAGGGATCTGCTGTCTGGCCGAGGAGCTA
TGCCACATCCATTCCAGGTACCAGGGTAGCTACTGGAAGGCTGTGAGGGCCTGTGTGGATTGTC
CCATCCGCCGTGGAGCTGTGCTGCTGCTGTCCTGCTATTTCTACTGCTCCCTCCCAAACCCCAC
TGGCCAGCCCCTCAGCTCGATGCTGGCCTTCCTGGGCCTCTCACAGGCCCTGAGCATCCTCCTG
GGTCTCCAGGGCCTGGCTCCAGCTGAAGTCTCTGCAGTCTGCGAAAAAAGGAACTTCAACGTCG
CCCAAGGACTGGCATGGTCATATTATGTTGGATACCTGCGGCTGATCCTGCCAGGACTCCGGGC
TCGGATCCAAATTTATAACCAGTTCCACAACAACATGCTACGAGGTGCAGGGAGCCAACGGCTG
TATATCCTCTTCCCGCTGGAGTGTGGGGTGCCTGATGACCTGAGTGTAGCTGACCCCAACATTC
GCTTCCTGCATACACTGCCCCAGCAGAGTGCTGACCGTGCTGGCATCAAAGGTCGGGTTTACTC
CAACAGCATCTATGAGCTTCTGGAGAATGGGAAGCCGGCAGGTACCTGTGTCCTGGAGTATGCC
ACCCCCTTGCAGACCTTGTTTGCCATGTCACAGGATGGCAGAGCTGGCTTTAGCCGGGAGGATC
GGCTTGAACAGGCCAAACTCTTCTGTCGAACACTTGAGGACATCCTGGCAGAAGTCCCTGAGTG
TCAGAACAACTGTCGCCTCATTGTCTACCAGGAATCTGCAGAGGGGAGCAGCTTCTTGCTGTCA
CAGGAAGTTCTCCGGCACATGCGGCAGGAGGAAAAAGAGGAGGTTACTTTGAGCAGCATGGGAA
CCTCAGTGGTGCCCAGTTCTTCCACCCTGTCCCAAGAGCCCAAGCTCCTCATCAGTGATATGGA
ACAGCCTCTCCCACTCCGCACTGATGTCTTCTGAGGCCCAGGGTCATCTTGCCTGAGCCTTCGA
GAATCAGAACTGGAGCTTGCTTCAACTGCTGGATGTTCAGCAGAGCCATGCCTCCCAAAGAGGA
CTTTACAGAGAAAGTTTCTGGACTTGACATCTCCAGATGAGTCCTGTATCCATGGGCAAGCCAT
TTTACCTTTTTGAGCCAGAATCTCTTCTACAAAATGGGATTATAATTATTGCCCTACCTCACAG
GGTTGTTGTGAGGACTGAGCATATGTAGAAGTTGTATCTAAGCTCTAAGTACCAGGTAAACTTA
AGGGGTATGCCAGTTATTTTCCATTAGACCCTCTAGTGCCCAGGGACAGATTTGTCTGGGTGGC
ATAACAGACTCCCTTGTCCTTGGATTTCTGGTCATGTTTGGTCAATGGGGAGCTTCAGCAGGAG
AATGGAGAGAGGAAGAGGTTGGGGTGTTTATCCCAGCTCCCTCCTGGCAGTTCAGAAGTTGAGT
GGGCCCTCTTGACAAGTGACCCTCCTGGCAAACCTGTCCATCTCTAGGTTTTGGGAACTGCCTC
CTCTCCTTACCCCTGGCAGTGGCATTGGCTCTCCAGTAGAGGCCTCACCCTCATTGTGGTTTCC
TTATGTCCTGCCCTTTCTCAATGTTCTTTTTTATTTGAAGTGGTGGTGGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005327332	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017977.1
GenBank Protein	KAG3266186	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005327332 ⟸ XM_005327275

- UniProtKB:

I3N0T1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPCSRLHPSIPYPRGHRAQQMALILLGACLVALWGLGNSPDHTLQYLVFYLASLQLGLLLKGIC
CLAEELCHIHSRYQGSYWKAVRACVDCPIRRGAVLLLSCYFYCSLPNPTGQPLSSMLAFLGLSQ
ALSILLGLQGLAPAEVSAVCEKRNFNVAQGLAWSYYVGYLRLILPGLRARIQIYNQFHNNMLRG
AGSQRLYILFPLECGVPDDLSVADPNIRFLHTLPQQSADRAGIKGRVYSNSIYELLENGKPAGT
CVLEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILAEVPECQNNCRLIVYQESAEG
SSFLLSQEVLRHMRQEEKEEVTLSSMGTSVVPSSSTLSQEPKLLISDMEQPLPLRTDVF

hide sequence

Ensembl Acc Id:

ENSSTOP00000017977 ⟸ ENSSTOT00000028461

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027444	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028461.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.5200	UniProtKB/TrEMBL
	3.40.50.12100	UniProtKB/TrEMBL
InterPro	STING	UniProtKB/TrEMBL
	STING_C_chordates	UniProtKB/TrEMBL
	STING_C_sf	UniProtKB/TrEMBL
NCBI Gene	Tmem173	ENTREZGENE
PANTHER	PTHR34339	UniProtKB/TrEMBL
	STIMULATOR OF INTERFERON GENES PROTEIN	UniProtKB/TrEMBL
Pfam	TMEM173	UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
UniProt	I3N0T1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-03	Sting1	stimulator of interferon response cGAMP interactor 1	Tmem173	transmembrane protein 173	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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