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Gene: Ucp1 (uncoupling protein 1) Ictidomys tridecemlineatus

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Symbol:

Ucp1

Name:

uncoupling protein 1

RGD ID:

12646701

Description:

ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); oxidative phosphorylation uncoupler activity (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); cellular response to dehydroepiandrosterone (ortholog); cellular response to hormone stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); congestive heart failure (ortholog); dilated cardiomyopathy (ortholog); FOUND IN mitochondrial inner membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mitochondrial brown fat uncoupling protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UCP1 (uncoupling protein 1)	NCBI	Ortholog
Mus musculus (house mouse):	Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ucp1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ucp1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UCP1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UCP1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UCP1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UCP1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ucp1 (uncoupling protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	49,820,808 - 49,828,140 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936535	7,258,343 - 7,265,398 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936535	7,258,146 - 7,265,475 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

congestive heart failure (ISO)

Diabetic Nephropathies (ISO)

dilated cardiomyopathy (ISO)

Huntington's disease (ISO)

hypertension (ISO)

Insulin Resistance (ISO)

obesity (ISO)

prediabetes syndrome (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive thermogenesis (IEA)

brown fat cell differentiation (IEA,ISO)

cellular response to cold (IEA)

cellular response to dehydroepiandrosterone (ISO)

cellular response to fatty acid (IEA)

cellular response to hormone stimulus (IEA,ISO)

cellular response to reactive oxygen species (IEA)

diet induced thermogenesis (IEA)

mitochondrial transmembrane transport (IEA)

mitochondrial transport (ISO)

monoatomic ion transmembrane transport (IEA)

positive regulation of cold-induced thermogenesis (IEA)

proton transmembrane transport (IEA,ISO)

regulation of reactive oxygen species biosynthetic process (IEA)

regulation of transcription by RNA polymerase II (IEA,ISO)

response to nutrient levels (IEA)

response to temperature stimulus (IEA)

transmembrane transport (IEA)

Cellular Component

mitochondrial envelope (IEA)

mitochondrial inner membrane (IEA,ISO)

mitochondrion (IEA)

Molecular Function

cardiolipin binding (IEA)

GDP binding (ISO)

GTP binding (ISO)

long-chain fatty acid binding (IEA)

oxidative phosphorylation uncoupler activity (IEA,ISO)

protein binding (ISO)

proton transmembrane transporter activity (IEA)

purine ribonucleotide binding (IEA)

transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ucp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	49,820,808 - 49,828,140 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936535	7,258,343 - 7,265,398 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936535	7,258,146 - 7,265,475 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UCP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	140,559,431 - 140,568,961 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	140,559,431 - 140,568,961 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	141,480,585 - 141,490,115 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	141,700,500 - 141,709,457 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	141,838,654 - 141,847,612	NCBI
Celera	4	138,811,044 - 138,819,947 (-)	NCBI		Celera
Cytogenetic Map	4	q31.1	NCBI
HuRef	4	137,211,503 - 137,220,406 (-)	NCBI		HuRef
CHM1_1	4	141,458,398 - 141,467,306 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	143,879,138 - 143,888,662 (-)	NCBI		T2T-CHM13v2.0

Ucp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	84,016,977 - 84,025,085 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	84,016,981 - 84,025,081 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	83,290,348 - 83,298,456 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	83,290,352 - 83,298,452 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	85,814,247 - 85,822,355 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	86,180,467 - 86,188,157 (+)	NCBI		MGSCv36	mm8
Celera	8	87,564,747 - 87,572,801 (+)	NCBI		Celera
Cytogenetic Map	8	C2	NCBI
cM Map	8	39.65	NCBI

Ucp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	41,713,350 - 41,721,421 (-)	NCBI		GRCr8
mRatBN7.2	19	24,808,782 - 24,816,853 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	24,808,783 - 24,816,852 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	31,627,843 - 31,635,958 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	32,282,249 - 32,290,366 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	34,500,303 - 34,508,418 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	24,456,976 - 24,464,808 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	24,456,976 - 24,464,807 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	35,434,980 - 35,442,812 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	26,527,548 - 26,535,621 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	26,532,373 - 26,540,447 (-)	NCBI
Celera	19	24,348,444 - 24,356,517 (-)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

Ucp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	3,274,810 - 3,283,237 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	3,253,363 - 3,282,518 (+)	NCBI	ChiLan1.0	ChiLan1.0

UCP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	138,435,652 - 138,445,332 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	138,823,275 - 138,832,954 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	132,921,033 - 132,930,714 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	144,230,858 - 144,239,803 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	144,230,858 - 144,240,178 (-)	Ensembl	panpan1.1		panPan2

UCP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	2,254,881 - 2,289,902 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	2,528,227 - 2,536,537 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	2,346,071 - 2,354,913 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	2,344,973 - 2,354,916 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	2,283,269 - 2,291,546 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	2,644,470 - 2,652,732 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	3,000,436 - 3,008,747 (+)	NCBI		UU_Cfam_GSD_1.0

UCP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	86,522,028 - 86,526,162 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	91,981,524 - 91,985,738 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UCP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	87,492,444 - 87,502,894 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	87,492,195 - 87,502,665 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	67,019,274 - 67,029,935 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ucp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004625006	155,100 - 162,551 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004625006	155,179 - 162,544 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005327565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MT114189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000003103 ⟹ ENSSTOP00000002774

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936535	7,258,343 - 7,265,398 (+)	Ensembl

RefSeq Acc Id:

XM_005327565 ⟹ XP_005327622

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405301	49,820,808 - 49,828,140 (+)	NCBI
SpeTri2.0	NW_004936535	7,258,146 - 7,265,475 (+)	NCBI

Sequence:

show sequence

GGGAGACGCGCGGGCTCGGTTGCACCACTGCGCTCCGCCTGCAGCCGTCACCTCTGGACTGCCA
CCTCCCTGGTGGTGGCTGTCCCAGAAGTCAGAGAGTGGGCTCGCTGCCCAGGCCGGGAGGGAAA
AGAACTTCCAACTTGGAGGTTGGAGCCTTTCGCTCTTGCCAGGCGCCTGGCCCCGCTTTCTGAG
TGAGGATGGTGAGCCCCACGGCCTCCGACGTGCACCCGACCATGGGCATCAAGATCGTCTCAGC
CGGAGTGTCAGCCTGCTTGGCGGATGTGATCACCTTCCCGCTGGACACCGCCAAAGTCCGGCTA
CAGATCCAAGGCGAATTCCCTGTCTCCAGCGGTATTACGTATAAAGGAGTCCTGGGAACAATCA
CCACCCTGGCCAAAACCGAAGGGCCCATGAAACTGTACAGCGGGCTGCCCGCGGGACTGCAAAG
GCAAATCAGCTTCGCCTCTCTTAGGATCGGCCTCTACGATTCTGTCCAGGAGTTCTTCACCTCA
GGGGATGAAACACCCAGCTTGGGAAGCAAAATCTCAGCCGGACTCACAACTGGAGGAGTGGCAG
TGTTCATTGGGCAGCCCACCGAGGTGGTGAAGGTCAGGCTCCAAGCACAGAGCCACCTACACGG
TCTCAAACCTCGCTACACCGGGACCTACAACGCGTACAGAATTATAGCAACAACAGAGAGCTTC
AGGAGTCTTTGGAAAGGGACTACTCCTAATCTGTTGAGAAATGTCATCATCAATTGCACAGAGT
TGGTAACATATGACCTGATGAAGGGGGCTCTTGTGAGAAACAAAATCCTAGCAGATGATGTCCC
CTGCCACCTGCTGTCCGCTTTCGTCGCTGGATTTTGCACCACACTCCTGTCCTCGCCTGCTGAT
GTAGTGAAGACCAGATTTATTAACTCTCCGCCAGGGCAGTATACCAGCGTGCCCAGATGTGCAA
TGACAATGCTCCACCAGGAAGGGCCGTCGGCATTTTTCAAAGGATTTCTACCTTCCTTCCTGCG
ACTGGCATCCTGGAACCTCATTATGTTCGTGAGCTTTGAACAGCTGAAACGAGAATTGATGAAG
TCCAGGCAGACAGTGGACTGCGCCACATGATCAGCTTCCAGAAAAGCATGTAGCACATCAGAGG
GAATTGCTGATTGGATCCCTAATAAAAACAACCCCCAAACGAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005327622	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000002774.3
GenBank Protein	KAG3276159	(Get FASTA)	NCBI Sequence Viewer
	QLM02921	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005327622 ⟸ XM_005327565

- UniProtKB:

I3M1P1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVSPTASDVHPTMGIKIVSAGVSACLADVITFPLDTAKVRLQIQGEFPVSSGITYKGVLGTITT
LAKTEGPMKLYSGLPAGLQRQISFASLRIGLYDSVQEFFTSGDETPSLGSKISAGLTTGGVAVF
IGQPTEVVKVRLQAQSHLHGLKPRYTGTYNAYRIIATTESFRSLWKGTTPNLLRNVIINCTELV
TYDLMKGALVRNKILADDVPCHLLSAFVAGFCTTLLSSPADVVKTRFINSPPGQYTSVPRCAMT
MLHQEGPSAFFKGFLPSFLRLASWNLIMFVSFEQLKRELMKSRQTVDCAT

hide sequence

Ensembl Acc Id:

ENSSTOP00000002774 ⟸ ENSSTOT00000003103

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000003104	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000003103.3	UniProtKB/TrEMBL
Gene3D-CATH	1.50.40.10	UniProtKB/TrEMBL
InterPro	Mit_carrier	UniProtKB/TrEMBL
	Mito_Metabolite_Transporter	UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Ucp1	ENTREZGENE
PANTHER	MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED	UniProtKB/TrEMBL
	PTHR45618:SF19	UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/TrEMBL
PRINTS	MTUNCOUPLING	UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103506	UniProtKB/TrEMBL
UniProt	I3M1P1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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