Ephb1 (EPH receptor B1) - Rat Genome Database

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Gene: Ephb1 (EPH receptor B1) Ictidomys tridecemlineatus
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Symbol: Ephb1
Name: EPH receptor B1
RGD ID: 12646334
Description: ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN axon guidance (ortholog); camera-type eye morphogenesis (ortholog); central nervous system projection neuron axonogenesis (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH aortic dissection (ortholog); autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-B receptor 1; ephrin type-B receptor 1-like; LOC110598325
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560271,079,838 - 71,501,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365297,839,768 - 8,261,942 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365298,006,780 - 8,261,923 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
axon guidance  (IEA,ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
camera-type eye morphogenesis  (IEA,ISO)
cell adhesion  (IEA)
cell chemotaxis  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cell-substrate adhesion  (IEA)
central nervous system projection neuron axonogenesis  (IEA,ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
cranial nerve development  (IEA,ISO)
dendritic spine development  (IEA,ISO)
dendritic spine morphogenesis  (IEA,ISO)
detection of temperature stimulus involved in sensory perception of pain  (IEA)
ephrin receptor signaling pathway  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA)
establishment of cell polarity  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
hindbrain tangential cell migration  (ISO)
immunological synapse formation  (ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
modulation of chemical synaptic transmission  (IEA)
negative regulation of satellite cell differentiation  (IEA)
negative regulation of skeletal muscle satellite cell proliferation  (IEA)
nervous system development  (IEA)
neural precursor cell proliferation  (IEA)
neurogenesis  (IEA)
optic nerve morphogenesis  (IEA,ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of synapse assembly  (IEA)
protein autophosphorylation  (ISO)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of JNK cascade  (IEA)
retinal ganglion cell axon guidance  (IEA,ISO)
skeletal muscle satellite cell activation  (IEA)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ephb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560271,079,838 - 71,501,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365297,839,768 - 8,261,942 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365298,006,780 - 8,261,923 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383134,795,260 - 135,260,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3134,795,260 - 135,260,467 (+)EnsemblGRCh38hg38GRCh38
GRCh373134,514,102 - 134,979,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363135,996,950 - 136,461,999 (+)NCBINCBI36Build 36hg18NCBI36
Build 343135,996,957 - 136,462,003NCBI
Celera3132,940,535 - 133,405,242 (+)NCBICelera
Cytogenetic Map3q22.2NCBI
HuRef3131,890,822 - 132,356,715 (+)NCBIHuRef
CHM1_13134,478,274 - 134,942,745 (+)NCBICHM1_1
T2T-CHM13v2.03137,540,631 - 138,005,927 (+)NCBIT2T-CHM13v2.0
Ephb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399101,799,327 - 102,231,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9101,799,327 - 102,231,892 (-)EnsemblGRCm39 Ensembl
GRCm389101,922,128 - 102,354,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,922,128 - 102,354,693 (-)EnsemblGRCm38mm10GRCm38
MGSCv379101,824,458 - 102,257,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369101,778,391 - 102,210,896 (-)NCBIMGSCv36mm8
Celera9101,458,328 - 101,902,746 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map954.15NCBI
Ephb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88111,386,432 - 111,823,759 (-)NCBIGRCr8
mRatBN7.28102,507,549 - 102,944,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8102,507,549 - 102,944,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8108,174,355 - 108,610,838 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08106,373,671 - 106,810,017 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08104,216,189 - 104,652,675 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08110,376,954 - 110,813,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8110,376,954 - 110,813,000 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08109,782,848 - 110,218,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48106,871,856 - 107,328,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18106,892,184 - 107,347,611 (-)NCBI
Celera8101,892,152 - 102,327,473 (-)NCBICelera
Cytogenetic Map8q32NCBI
Ephb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555013,423,977 - 3,821,890 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555013,424,112 - 3,821,727 (-)NCBIChiLan1.0ChiLan1.0
EPHB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22132,721,019 - 133,188,676 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13132,725,745 - 133,193,405 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03131,841,459 - 132,309,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13139,312,933 - 139,778,166 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3139,313,387 - 139,776,802 (+)Ensemblpanpan1.1panPan2
EPHB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12331,485,701 - 31,918,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2331,485,534 - 31,917,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2331,423,133 - 31,897,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02332,297,984 - 32,440,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2332,322,030 - 32,439,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12331,656,516 - 32,130,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02331,717,030 - 32,191,562 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,963,973 - 32,438,568 (+)NCBIUU_Cfam_GSD_1.0
EPHB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1375,905,676 - 76,345,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11375,904,678 - 76,351,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21383,511,907 - 83,816,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11555,144,178 - 55,592,252 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1555,143,630 - 55,589,862 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604128,194,516 - 28,305,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473011,119,909 - 11,565,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473011,120,018 - 11,564,972 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000014873   ⟹   ENSSTOP00000013324
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365297,839,768 - 8,261,942 (+)Ensembl
RefSeq Acc Id: XM_040269825   ⟹   XP_040125759
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560271,222,370 - 71,501,426 (+)NCBI
RefSeq Acc Id: XM_040269826   ⟹   XP_040125760
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560271,079,838 - 71,501,438 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040125759 (Get FASTA)   NCBI Sequence Viewer  
  XP_040125760 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013324.2
GenBank Protein KAG3270687 (Get FASTA)   NCBI Sequence Viewer  
  KAG3270688 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_040125760   ⟸   XM_040269826
- Peptide Label: isoform X2
- UniProtKB: I3MNQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040125759   ⟸   XM_040269825
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000013324   ⟸   ENSSTOT00000014873
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014868 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014873.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphB1_rcpt_lig-bd UniProtKB/TrEMBL
  EphB1_SAM UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  Ephrin_rcpt_TKs UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene Ephb1 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-B RECEPTOR 1 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt I3MNQ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Ephb1  EPH receptor B1  LOC110598325  ephrin type-B receptor 1-like  Data merged from RGD:13080343 737654 PROVISIONAL