Il21 (interleukin 21) - Rat Genome Database

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Gene: Il21 (interleukin 21) Ictidomys tridecemlineatus
Analyze
Symbol: Il21
Name: interleukin 21
RGD ID: 12610946
Description: ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); interleukin-2 receptor binding (inferred); INVOLVED IN cellular response to virus (ortholog); germinal center B cell differentiation (ortholog); natural killer cell differentiation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Animal Toxoplasmosis (ortholog); anogenital venereal wart (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,610,108 - 122,621,066 (-)EnsemblGRCh38hg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
T2T-CHM13v2.04125,914,209 - 125,925,168 (-)NCBIT2T-CHM13v2.0
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 Ensembl
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.36NCBI
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,045,240 - 122,055,142 (-)NCBIGRCr8
mRatBN7.22120,117,105 - 120,127,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Celera2115,067,969 - 115,075,326 (-)NCBICelera
Cytogenetic Map2q25NCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,394,845 - 120,405,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,660,750 - 120,671,701 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,940,979 - 125,951,915 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)Ensemblpanpan1.1panPan2
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,760,158 - 17,769,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBIUU_Cfam_GSD_1.0
IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,054,368 - 3,061,304 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005336532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000012115   ⟹   ENSSTOP00000010864
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000042434   ⟹   ENSSTOP00000031177
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366621,689,920 - 1,696,883 (-)Ensembl
RefSeq Acc Id: XM_005336532   ⟹   XP_005336589
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBI
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005336589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000010864.2
  ENSSTOP00000031177.1
GenBank Protein KAG3276236 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005336589   ⟸   XM_005336532
- UniProtKB: I3MIK7 (UniProtKB/TrEMBL),   A0A287DC80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000031177   ⟸   ENSSTOT00000042434
Ensembl Acc Id: ENSSTOP00000010864   ⟸   ENSSTOT00000012115


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012108 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012115.2 UniProtKB/TrEMBL
  ENSSTOT00000042434.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.70 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-15/IL-21_fam UniProtKB/TrEMBL
NCBI Gene Il21 ENTREZGENE
PANTHER INTERLEUKIN-21 UniProtKB/TrEMBL
  PTHR14356 UniProtKB/TrEMBL
Pfam IL15 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A287DC80 ENTREZGENE, UniProtKB/TrEMBL
  I3MIK7 ENTREZGENE, UniProtKB/TrEMBL