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Gene: Nts (neurotensin) Ictidomys tridecemlineatus

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Symbol:

Nts

Name:

neurotensin

RGD ID:

12601118

Description:

ENCODES a protein that exhibits neuropeptide hormone activity (inferred); neuropeptide receptor binding (inferred); receptor ligand activity (inferred); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to lithium ion (ortholog); cellular response to nerve growth factor stimulus (ortholog); ASSOCIATED WITH Bradycardia (ortholog); breast ductal carcinoma (ortholog); Catalepsy (ortholog); FOUND IN axon terminus (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neurotensin/neuromedin N

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NTS (neurotensin)	NCBI	Ortholog
Mus musculus (house mouse):	Nts (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nts (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nts (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NTS (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NTS (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NTS (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NTS (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nts (neurotensin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	32,906,185 - 32,916,431 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936507	3,318,915 - 3,329,342 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936507	3,318,982 - 3,329,248 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bradycardia (ISO)

breast ductal carcinoma (ISO)

Catalepsy (ISO)

depressive disorder (ISO)

Experimental Arthritis (ISO)

Hyperkinesis (ISO)

Hypovolemia (ISO)

invasive ductal carcinoma (ISO)

Muscle Rigidity (ISO)

Peripheral Nerve Injuries (ISO)

sciatic neuropathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel diameter maintenance (IEA)

cellular response to dexamethasone stimulus (ISO)

cellular response to lithium ion (ISO)

cellular response to nerve growth factor stimulus (ISO)

digestive tract development (ISO)

hyperosmotic response (ISO)

liver development (ISO)

negative regulation of gene expression (IEA,ISO)

neuropeptide signaling pathway (IEA)

positive regulation of gene expression (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

regulation of locomotion involved in locomotory behavior (ISO)

response to amphetamine (ISO)

response to antipsychotic drug (ISO)

response to axon injury (ISO)

response to cocaine (ISO)

response to corticosterone (ISO)

response to estradiol (ISO)

response to mineralocorticoid (ISO)

visual learning (ISO)

Cellular Component

axon terminus (IEA,ISO)

cytoplasmic vesicle (IEA)

extracellular region (IEA)

intracellular membrane-bounded organelle (IEA)

neuronal cell body (ISO)

transport vesicle (IEA)

Molecular Function

neuropeptide hormone activity (IEA)

neuropeptide receptor binding (IEA)

protein binding (ISO)

receptor ligand activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Nts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	32,906,185 - 32,916,431 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936507	3,318,915 - 3,329,342 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936507	3,318,982 - 3,329,248 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NTS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	85,874,295 - 85,882,992 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	85,874,295 - 85,882,992 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	86,268,073 - 86,276,770 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	84,792,206 - 84,800,898 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	84,770,542 - 84,779,231	NCBI
Celera	12	85,930,823 - 85,939,559 (+)	NCBI		Celera
Cytogenetic Map	12	q21.31	NCBI
HuRef	12	83,324,584 - 83,333,603 (+)	NCBI		HuRef
CHM1_1	12	86,233,027 - 86,241,361 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	85,854,932 - 85,863,806 (+)	NCBI		T2T-CHM13v2.0

Nts
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	102,317,617 - 102,326,294 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	102,317,617 - 102,326,347 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	102,481,756 - 102,490,418 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	102,481,756 - 102,490,486 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	101,944,390 - 101,953,052 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	101,911,444 - 101,920,106 (-)	NCBI		MGSCv36	mm8
Celera	10	104,415,989 - 104,424,662 (-)	NCBI		Celera
Cytogenetic Map	10	D1	NCBI
cM Map	10	53.56	NCBI

Nts
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	39,451,484 - 39,460,888 (-)	NCBI		GRCr8
mRatBN7.2	7	37,564,944 - 37,574,350 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	37,564,533 - 37,574,423 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	39,491,733 - 39,501,228 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	41,694,804 - 41,704,299 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	41,469,771 - 41,479,266 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	44,111,594 - 44,120,998 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	44,111,151 - 44,121,130 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	44,140,647 - 44,150,051 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	40,474,654 - 40,484,058 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	40,494,497 - 40,495,295 (-)	NCBI
Celera	7	34,527,468 - 34,536,872 (-)	NCBI		Celera
Cytogenetic Map	7	q21	NCBI

Nts
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	23,748,280 - 23,758,529 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	23,696,258 - 23,758,487 (+)	NCBI	ChiLan1.0	ChiLan1.0

NTS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	93,932,967 - 93,940,591 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	93,929,364 - 93,936,989 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	83,402,313 - 83,410,356 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	86,640,722 - 86,648,708 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	86,640,720 - 86,648,745 (+)	Ensembl	panpan1.1		panPan2

NTS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	27,361,002 - 27,372,232 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	27,361,002 - 27,372,232 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	27,806,896 - 27,818,114 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	27,977,054 - 27,988,287 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	27,977,054 - 27,988,287 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	27,329,416 - 27,340,646 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	27,370,112 - 27,381,344 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	27,659,448 - 27,670,671 (+)	NCBI		UU_Cfam_GSD_1.0

NTS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	96,260,560 - 96,272,976 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	96,261,299 - 96,272,947 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	101,076,752 - 101,088,628 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NTS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	81,270,147 - 81,278,327 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	81,270,593 - 81,277,713 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	164,046,316 - 164,054,238 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nts
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624837	5,035,159 - 5,045,651 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624837	5,035,237 - 5,045,560 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005324414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000010246 ⟹ ENSSTOP00000009194

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936507	3,318,915 - 3,329,342 (+)	Ensembl

RefSeq Acc Id:

XM_005324414 ⟹ XP_005324471

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	32,906,185 - 32,916,431 (-)	NCBI
SpeTri2.0	NW_004936507	3,318,982 - 3,329,248 (+)	NCBI

Sequence:

show sequence

GGAAGAGATGAGGGACAAAGGAAAAAGGGAGGAGGAAGTGGGGGGAGAAAGAGAGGGATAGAAA
TGAGGACAGGAACACCCCTAATCCCTGTACAGTCATGACATCATCCTCCTGCTTAAATATATAT
AGGGAATGGCCAGAGCATCTCTTATAGTTCTCTCACTCTCAGAGTCAGCTGAAGGCTAGAGAAA
GCTCTACAGAAAGCCTTTCAGTGTCTGACTTCTGTGGACTTGGCTTGAGAGAAGGCTGAGAGAG
ATGATGGCAAGCATGAAAATCCACCTGGTGTGCATGATACTCCTGGCTTGCAGCTCCTGGAGTC
TGTGCTCAGATTCTGAAGAGGAAATGAAAGCATTAGAAGCAGATTTATTGACCAATATACATAC
GTCAAAGATCAGTAAAGCAAGTGTTCCTTCATGGAAAATGACCCTGCTAAATGTCTGCAGTTTT
ATAAATAACTTCAACGGCCAAACTGAGGAAACAGGAGAGGTTCATGAGGAAGAACTTGTTACAA
GAAGGAAACTTCCTGTTGTTCTAGATGGCTTTAGCCTGGAAGCAATGCTGACAATCTACCAGCT
CCAAAAAATCTGTCACAGCCGAGCCTTTCAACACTGGGAGATAATTCAGGAAGACATTCTTGAT
AATGGAAATGAAAAAAATGAGAAGGAAGAAGTCATAAAGAGAAAAATTCCTTACATCCTGAAAA
GGCAACTGTATGAGAATAAACCAAGAAGACCCTACATACTTAAAAGGGGTTCTTACTACTACTG
AGGAGATATTCATTTTCTTTACATTTGATTGTGATTTATCATCCTTGTTTGAATACTAATTATA
TATGTGTGAAAATGTGACAAAATATGCTAATTTTGACTCTTCCACAATTGTGGTGTATTGGGTG
TGATTTTTCTGCATACATATAAATTGGACTAAAAGTTTTCAAATAAATCTACATCTTGAGCATG
ATGTGTTATGTATAATTGGAATAAACAGCTATCACGTTACATATAGCGTGTTTTGTAGTTTTGC
AAAACACATTATGGGTTGTTTAAACAGTCAAAATGTTTGACATTTTATGTGAAATTATGAGAAA
TTCTAACAAAGTAGGACAGCAAAGTCTAGCCTATATTATCATTAATACAAAACAAAGTAATGGC
ACATATTCTGTTATTTGACTGAGTATTTTATCAAATTGAGAGGAATACTTTCTTTTTTCAAGAC
TCACTCATGTATCTCATATATAAGGATAGTTGTTGTAGGCCCATCAGAAAGACTGATAAGTGGC
CTGTTGTTAATTTTGCCTGCTGTAGTGAATGGTTTTCAAGTGAAATTTTGTCTGTGCAATGAAT
TTGATAGCTAATAAAAAGACAATAAGCCATCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005324471	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009194.3
GenBank Protein	KAG3291297	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005324471 ⟸ XM_005324414
- UniProtKB:	I3MF44 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMASMKIHLVCMILLACSSWSLCSDSEEEMKALEADLLTNIHTSKISKASVPSWKMTLLNVCSF INNFNGQTEETGEVHEEELVTRRKLPVVLDGFSLEAMLTIYQLQKICHSRAFQHWEIIQEDILD NGNEKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY hide sequence

Ensembl Acc Id:

ENSSTOP00000009194 ⟸ ENSSTOT00000010246

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010252	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000010246.3	UniProtKB/TrEMBL
InterPro	NeurotensiN	UniProtKB/TrEMBL
NCBI Gene	Nts	ENTREZGENE
PANTHER	NEUROTENSIN/NEUROMEDIN N	UniProtKB/TrEMBL
	PTHR15356	UniProtKB/TrEMBL
Pfam	Pro-NT_NN	UniProtKB/TrEMBL
PRINTS	NEUROTENSIN	UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
UniProt	I3MF44	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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