Ezr (ezrin) - Rat Genome Database

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Gene: Ezr (ezrin) Ictidomys tridecemlineatus
Analyze
Symbol: Ezr
Name: ezrin
RGD ID: 12598505
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); establishment of epithelial cell apical/basal polarity (ortholog); filopodium assembly (ortholog); PARTICIPATES IN FasL mediated signaling pathway; parathyroid hormone signaling pathway; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte projection (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ezrin, transcript variant X1; ezrin, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament bundle assembly  (IEA)
astral microtubule organization  (IEA)
cellular response to cAMP  (IEA)
cortical microtubule organization  (IEA)
epithelial cell differentiation  (ISO)
establishment of centrosome localization  (IEA)
establishment of endothelial barrier  (IEA)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of apical/basal cell polarity  (IEA)
filopodium assembly  (IEA,ISO)
gland morphogenesis  (ISO)
intestinal D-glucose absorption  (IEA)
leukocyte cell-cell adhesion  (IEA)
membrane to membrane docking  (IEA)
microvillus assembly  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of interleukin-2 production  (IEA)
negative regulation of p38MAPK cascade  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of early endosome to late endosome transport  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of multicellular organism growth  (IEA)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein localization to early endosome  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
postsynaptic actin cytoskeleton organization  (IEA)
protein kinase A signaling  (IEA)
protein localization to cell cortex  (IEA)
protein localization to plasma membrane  (IEA)
protein-containing complex localization  (IEA)
receptor internalization  (IEA)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell shape  (IEA)
regulation of cell size  (ISO)
regulation of microvillus length  (IEA)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of organelle assembly  (IEA)
sphingosine-1-phosphate receptor signaling pathway  (IEA)
terminal web assembly  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ezr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386158,765,748 - 158,819,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6158,765,741 - 158,819,368 (-)EnsemblGRCh38hg38GRCh38
GRCh376159,186,780 - 159,240,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,106,764 - 159,159,247 (-)NCBINCBI36Build 36hg18NCBI36
Build 346159,157,186 - 159,209,668NCBI
Celera6159,834,789 - 159,888,323 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6156,657,307 - 156,711,123 (-)NCBIHuRef
CHM1_16159,449,491 - 159,503,058 (-)NCBICHM1_1
T2T-CHM13v2.06160,010,984 - 160,064,812 (-)NCBIT2T-CHM13v2.0
Ezr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,005,530 - 7,050,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,005,440 - 7,050,183 (-)EnsemblGRCm39 Ensembl
GRCm38176,738,131 - 6,782,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl176,738,041 - 6,782,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv37176,942,480 - 6,987,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36176,587,789 - 6,632,438 (-)NCBIMGSCv36mm8
Celera1514,687,905 - 14,732,667 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.38NCBI
Ezr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,373,033 - 49,416,573 (-)NCBIGRCr8
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Celera142,655,531 - 42,699,079 (-)NCBICelera
Cytogenetic Map1q11NCBI
Ezr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554393,703,013 - 3,740,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554393,701,722 - 3,740,345 (+)NCBIChiLan1.0ChiLan1.0
EZR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25178,869,668 - 178,923,683 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16176,774,286 - 176,828,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16161,670,483 - 161,723,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensemblpanpan1.1panPan2
EZR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBIUU_Cfam_GSD_1.0
EZR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18,403,453 - 8,452,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118,403,362 - 8,452,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,423,530 - 10,432,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11386,342,954 - 86,399,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,344,051 - 86,370,622 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604058,721,321 - 58,778,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624929826,531 - 873,572 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624929827,275 - 873,743 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000006350   ⟹   ENSSTOP00000005678
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648910,414,512 - 10,434,999 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000031619   ⟹   ENSSTOP00000031192
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000042869   ⟹   ENSSTOP00000030029
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,449,561 (-)Ensembl
RefSeq Acc Id: XM_005321411   ⟹   XP_005321468
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBI
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321468 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000005678.3
  ENSSTOP00000030029.1
  ENSSTOP00000031192.1
GenBank Protein KAG3290512 (Get FASTA)   NCBI Sequence Viewer  
  KAG3290513 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005321468   ⟸   XM_005321411
- UniProtKB: A0A287DC95 (UniProtKB/TrEMBL),   I3M7R6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000005678   ⟸   ENSSTOT00000006350
Ensembl Acc Id: ENSSTOP00000030029   ⟸   ENSSTOT00000042869
Ensembl Acc Id: ENSSTOP00000031192   ⟸   ENSSTOT00000031619
Protein Domains
FERM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006325 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006350.3 UniProtKB/TrEMBL
  ENSSTOT00000031619.1 UniProtKB/TrEMBL
  ENSSTOT00000042869.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.450 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  ERM UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Ezr ENTREZGENE
PANTHER PTHR23281 UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PIRSF ERM UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF48678 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A287D914_ICTTR UniProtKB/TrEMBL
  A0A287DC95 ENTREZGENE, UniProtKB/TrEMBL
  I3M7R6 ENTREZGENE, UniProtKB/TrEMBL