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Gene: Hsp90ab1 (heat shock protein 90 alpha family class B member 1) Ictidomys tridecemlineatus

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Symbol:

Hsp90ab1

Name:

heat shock protein 90 alpha family class B member 1

RGD ID:

12582915

Description:

ENCODES a protein that exhibits ATP binding (ortholog); CTP binding (ortholog); dATP binding (ortholog); INVOLVED IN cellular response to interleukin-4 (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of complement-dependent cytotoxicity (ortholog); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; ASSOCIATED WITH Female Infertility (ortholog); human immunodeficiency virus infectious disease (ortholog); intrahepatic cholangiocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); brush border membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock protein HSP 90-beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	48,123,181 - 48,129,743 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	15,830,459 - 15,835,535 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	15,830,459 - 15,836,994 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Female Infertility (ISO)

human immunodeficiency virus infectious disease (ISO)

intrahepatic cholangiocarcinoma (ISO)

multiple sclerosis (ISO)

muscular atrophy (ISO)

pancreatitis (ISO)

Prostatic Neoplasms (ISO)

pulmonary fibrosis (ISO)

Spinal Cord Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (IEA)

cellular response to interleukin-4 (IEA,ISO)

chaperone-mediated protein complex assembly (IEA)

chaperone-mediated protein folding (IEA)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of complement-dependent cytotoxicity (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of proteasomal protein catabolic process (IEA)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

placenta development (IEA,ISO)

positive regulation of cell differentiation (IEA)

positive regulation of cell size (ISO)

positive regulation of protein binding (ISO)

positive regulation of protein import into nucleus (ISO)

positive regulation of protein localization to cell surface (IEA)

positive regulation of protein serine/threonine kinase activity (ISO)

positive regulation of transforming growth factor beta receptor signaling pathway (IEA)

protein folding (IEA)

regulation of cell cycle (IEA)

regulation of protein localization (IEA)

regulation of protein ubiquitination (IEA)

response to cocaine (ISO)

response to salt stress (ISO)

response to xenobiotic stimulus (ISO)

supramolecular fiber organization (IEA)

telomerase holoenzyme complex assembly (IEA)

telomere maintenance via telomerase (IEA,ISO)

virion attachment to host cell (IEA)

Cellular Component

apical plasma membrane (ISO)

aryl hydrocarbon receptor complex (IEA)

axonal growth cone (IEA)

basolateral plasma membrane (ISO)

brush border membrane (ISO)

cell surface (ISO)

COP9 signalosome (IEA,ISO)

cytoplasm (IEA)

cytosol (IEA)

dendritic growth cone (IEA)

extracellular region (IEA)

HSP90-CDC37 chaperone complex (IEA)

inclusion body (ISO)

lysosomal membrane (ISO)

melanosome (IEA)

neuronal cell body (IEA)

nucleus (IEA)

ooplasm (ISO)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

protein folding chaperone complex (IEA,ISO)

protein-containing complex (IEA)

sperm head plasma membrane (ISO)

Molecular Function

ATP binding (IEA,ISO)

ATP hydrolysis activity (IEA)

ATP-dependent protein binding (IEA)

ATP-dependent protein folding chaperone (IEA)

CTP binding (ISO)

dATP binding (ISO)

disordered domain specific binding (IEA)

DNA polymerase binding (IEA)

double-stranded RNA binding (IEA)

GTP binding (ISO)

heat shock protein binding (IEA)

heterocyclic compound binding (ISO)

histone deacetylase binding (IEA)

histone methyltransferase binding (IEA)

identical protein binding (IEA)

kinase binding (IEA)

peptide binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

protein folding chaperone (IEA)

protein homodimerization activity (IEA)

protein kinase binding (IEA)

protein kinase regulator activity (IEA,ISO)

protein phosphatase activator activity (IEA)

receptor ligand inhibitor activity (IEA)

sulfonylurea receptor binding (ISO)

tau protein binding (IEA)

transmembrane transporter binding (ISO)

ubiquitin protein ligase binding (IEA)

unfolded protein binding (IEA)

UTP binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

aldosterone signaling pathway (ISO)

androgen signaling pathway (ISO)

cortisol signaling pathway (ISO)

estrogen signaling pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hsp90ab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	48,123,181 - 48,129,743 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	15,830,459 - 15,835,535 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	15,830,459 - 15,836,994 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSP90AB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	44,246,194 - 44,253,883 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	44,246,166 - 44,253,888 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	44,213,931 - 44,221,620 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	44,322,827 - 44,329,592 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	44,322,826 - 44,329,592	NCBI
Celera	6	45,767,994 - 45,774,759 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	43,935,917 - 43,943,640 (+)	NCBI		HuRef
CHM1_1	6	44,217,626 - 44,225,330 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	44,080,360 - 44,088,031 (+)	NCBI		T2T-CHM13v2.0

Hsp90ab1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	45,878,704 - 45,884,187 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	45,878,701 - 45,884,197 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	45,567,778 - 45,573,261 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	45,567,775 - 45,573,271 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	45,704,727 - 45,710,210 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	45,031,359 - 45,036,842 (-)	NCBI		MGSCv36	mm8
Celera	17	49,000,428 - 49,005,921 (-)	NCBI		Celera
Cytogenetic Map	17	B3	NCBI
cM Map	17	22.59	NCBI

Hsp90ab1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	22,930,249 - 22,935,929 (+)	NCBI		GRCr8
mRatBN7.2	9	15,432,986 - 15,438,358 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	15,433,691 - 15,438,488 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	24,019,488 - 24,024,885 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	29,082,165 - 29,087,562 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	27,382,927 - 27,388,324 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	17,817,791 - 17,823,163 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	17,817,721 - 17,823,243 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	16,706,512 - 16,711,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	11,033,496 - 11,038,868 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	11,030,786 - 11,036,319 (+)	NCBI
Celera	9	13,176,225 - 13,181,597 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

Hsp90ab1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	9,873,908 - 9,878,459 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	9,872,649 - 9,878,459 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSP90AB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	58,750,514 - 58,757,909 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	54,620,583 - 54,627,983 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	43,842,796 - 43,849,637 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	45,126,060 - 45,132,972 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	45,125,773 - 45,133,872 (+)	Ensembl	panpan1.1		panPan2

HSP90AB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	12,658,415 - 12,664,945 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	12,660,008 - 12,664,940 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	12,682,075 - 12,689,685 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	13,139,324 - 13,147,144 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	13,140,459 - 13,147,650 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	12,665,005 - 12,672,579 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	12,752,685 - 12,760,264 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	12,846,448 - 12,854,258 (+)	NCBI		UU_Cfam_GSD_1.0

HSP90AB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	39,244,458 - 39,250,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	39,237,299 - 39,250,479 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	45,106,779 - 45,119,936 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSP90AB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	27,914,261 - 27,921,666 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	27,911,013 - 27,921,251 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	44,300,580 - 44,307,963 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsp90ab1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	15,609,920 - 15,614,263 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	15,609,932 - 15,615,580 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040282730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000027899 ⟹ ENSSTOP00000022132

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936476	15,830,459 - 15,835,535 (-)	Ensembl

RefSeq Acc Id:

XM_005318621 ⟹ XP_005318678

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	48,123,181 - 48,129,743 (+)	NCBI
SpeTri2.0	NW_004936476	15,830,459 - 15,836,994 (-)	NCBI

Sequence:

show sequence

TATATAGAGCGACTGGGGGCACACGGTAGCTCTCTTGAGTCACCCCCACGCTGCCTAGGTGTCG
CGAGCGAGTCGCACACTCTTCGGGCCCACCCTTCTTTAACACTCGCAGTCCTTTCTCTCTCAAG
ATGCCTGAGGAAGTGCACCATGGAGAGGAGGAGGTGGAGACGTTTGCCTTTCAGGCAGAAATTG
CCCAACTCATGTCTCTCATCATCAATACCTTTTATTCCAACAAGGAAATTTTCCTTCGGGAATT
GATCTCTAATGCTTCTGATGCCTTGGACAAGATTCGATATGAGAGCCTGACAGACCCTTCCAAG
TTGGACAGTGGTAAAGAGCTGAAAATTGACATAATCCCCAACCCTCAGGAAAGGACTCTGACTT
TGGTGGACACAGGCATTGGCATGACCAAGGCTGATCTCATAAACAACTTGGGAACCATTGCCAA
GTCTGGAACTAAAGCATTTATGGAGGCTCTTCAGGCTGGTGCAGACATATCCATGATTGGGCAA
TTTGGTGTTGGATTTTATTCTGCTTATCTAGTGGCAGAGAAAGTGGTTGTGATCACAAAGCATA
ATGATGATGAACAGTATGCTTGGGAGTCTTCTGCTGGGGGATCTTTCACTGTGCGGGCTGATCA
TGGTGAGCCCATTGGCCGGGGTACTAAAGTCATTCTCCACCTCAAAGAAGACCAGACAGAGTAC
TTGGAGGAGAGGCGTGTCAAAGAAGTGGTGAAGAAGCACTCACAGTTCATAGGCTATCCAATCA
CCCTTTATTTGGAGAAGGAACGAGAGAAGGAAATCAGTGATGATGAGGCAGAGGAAGAGAAAGG
TGAGAAAGAAGAGGAAGATAAAGATGATGAGGAGAAACCCAAGATTGAAGATGTGGGCTCAGAT
GAGGAGGATGACACTAGTAAGGATAAGAAGAAGAAAACAAAGAAGATTAAGGAGAAATATATTG
ATCAAGAAGAACTGAACAAGACCAAGCCCATTTGGACCAGAAACCCTGATGACATCACTCAGGA
AGAATATGGAGAATTCTACAAGAGCCTAACCAATGATTGGGAAGACCACCTGGCAGTCAAGCAC
TTCTCTGTAGAAGGTCAGTTGGAATTCAGGGCATTGCTGTTCATCCCTCGGCGGGCTCCCTTTG
ACCTCTTTGAGAACAAGAAGAAGAAGAACAACATCAAACTCTATGTCCGTCGTGTGTTCATCAT
GGAGAGTTGTGATGAGCTGATACCAGAGTATCTCAATTTTATTCGTGGTGTTGTTGACTCTGAG
GATCTGCCCCTGAATATCTCCCGAGAAATGCTCCAGCAGAGCAAAATCTTGAAAGTTATTCGCA
AAAACATTGTGAAGAAGTGCCTTGAGCTCTTCTCTGAGTTGGCAGAAGACAAGGAGAACTACAA
AAAATTCTATGAGGCATTCTCTAAAAATCTTAAGCTTGGAATCCATGAAGATTCTACTAATCGG
CGACGCCTTTCTGAGCTGCTGCGCTACCACACCTCTCAGTCTGGAGATGAGATGACTTCTCTGT
CAGAGTATGTCTCTCGCATGAAGGAGACACAGAAGTCCATCTATTACATTACTGGTGAAAGCAA
AGAGCAGGTGGCCAACTCTGCTTTTGTGGAGCGTGTGCGGAAGCGTGGCTTTGAGGTAGTATAT
ATGACTGAGCCTATTGATGAGTACTGTGTACAGCAACTCAAGGAGTTTGATGGGAAGAGCCTGG
TCTCTGTGACCAAGGAAGGCCTGGAGCTACCTGAGGATGAGGAGGAAAAAAAGAAAATGGAGGA
GAGCAAGGCGAAATTTGAGAACCTTTGCAAGCTTATGAAAGAAATCTTGGATAAAAAGGTTGAG
AAGGTGACAATCTCCAATAGGCTTGTGTCTTCACCCTGCTGCATTGTTACCAGCACCTATGGCT
GGACAGCCAATATGGAGCGGATTATGAAGGCCCAGGCACTTCGAGACAACTCCACAATGGGCTA
CATGATGGCCAAAAAGCACCTGGAGATCAACCCTGATCACCCCATTGTGGAGACATTGCGGCAA
AAGGCAGAGGCAGATAAAAATGACAAGGCTGTCAAGGACCTGGTGGTGCTGCTATTTGAAACTG
CGCTGCTCTCTTCTGGCTTCTCACTTGAGGATCCCCAGACCCACTCCAATCGCATCTACCGCAT
GATAAAGCTAGGCCTAGGCATTGATGAAGATGAAGTGACAGCAGAGGAACCCAGCAGTGCTGTT
CCTGATGAGATACCCCCTCTCGAGGGTGATGAGGATGCATCTCGCATGGAAGAAGTAGATTAGG
AGTTGCTACTGAGAAATCTGCCCTCTGTATAGTTTCCCCATGGCTCCCACAGTAGCCTTGAGTG
GCCCTCTCCCACCTGGCTTCCTCTGCTGATTGGTGTAATAGTGTTTTTTTCTCCTGTCCTTGGC
ATCTTAATTAAGGCAGGAAATAAGGGCCTCAAGCCCTCCATCCCCTACCTAGTTTGGCCGTAGG
GTTGGATGTTGTATTGTGTTTTTGTTTTATTTTGTTCCACAATTAAAGTATGCAAAATAAAGAA
GATGCAGTTTTATACA

hide sequence

RefSeq Acc Id:

XM_040282730 ⟹ XP_040138664

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404946	48,124,149 - 48,129,743 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005318678	(Get FASTA)	NCBI Sequence Viewer
	XP_040138664	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022132.1
GenBank Protein	KAG3289559	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318678 ⟸ XM_005318621

- UniProtKB:

I3NCN5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSK
LDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQ
FGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEY
LEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSD
EEDDTSKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKH
FSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMESCDELIPEYLNFIRGVVDSE
DLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNR
RRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVY
MTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVE
KVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ
KAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSSAV
PDEIPPLEGDEDASRMEEVD

hide sequence

RefSeq Acc Id:	XP_040138664 ⟸ XM_040282730
- UniProtKB:	I3NCN5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000022132 ⟸ ENSSTOT00000027899

Protein Domains

Histidine kinase/HSP90-like ATPase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024614	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000027899.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.790	UniProtKB/TrEMBL
	3.30.230.80	UniProtKB/TrEMBL
	3.30.565.10	UniProtKB/TrEMBL
	3.40.50.11260	UniProtKB/TrEMBL
InterPro	HATPase_C	UniProtKB/TrEMBL
	HATPase_C_sf	UniProtKB/TrEMBL
	Heat_shock_protein_90_CS	UniProtKB/TrEMBL
	HSP90_C	UniProtKB/TrEMBL
	Hsp90_fam	UniProtKB/TrEMBL
	Hsp90_N	UniProtKB/TrEMBL
	Ribosomal_S5_D2-typ_fold	UniProtKB/TrEMBL
NCBI Gene	Hsp90ab1	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN HSP 90-BETA	UniProtKB/TrEMBL
	PTHR11528	UniProtKB/TrEMBL
Pfam	HATPase_c_3	UniProtKB/TrEMBL
	HSP90	UniProtKB/TrEMBL
PIRSF	Hsp90	UniProtKB/TrEMBL
PRINTS	HEATSHOCK90	UniProtKB/TrEMBL
PROSITE	HSP90	UniProtKB/TrEMBL
SMART	HATPase_c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF110942	UniProtKB/TrEMBL
	SSF54211	UniProtKB/TrEMBL
	SSF55874	UniProtKB/TrEMBL
UniProt	I3NCN5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)