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Gene: Eda2r (ectodysplasin A2 receptor) Ictidomys tridecemlineatus

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Symbol:

Eda2r

Name:

ectodysplasin A2 receptor

RGD ID:

12575892

Description:

ENCODES a protein that exhibits signaling receptor activity (inferred); transmembrane signaling receptor activity (inferred); tumor necrosis factor receptor activity (inferred); INVOLVED IN cytokine-mediated signaling pathway (inferred); intrinsic apoptotic signaling pathway by p53 class mediator (inferred); positive regulation of canonical NF-kappaB signal transduction (inferred); ASSOCIATED WITH anodontia (ortholog); autistic disorder (ortholog); autosomal hemophilia A (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ectodysplasin A2 receptor, transcript variant X1; ectodysplasin A2 receptor, transcript variant X2; ectodysplasin A2 receptor, transcript variant X3; ectodysplasin A2 receptor, transcript variant X4; ectodysplasin A2 receptor, transcript variant X5; tumor necrosis factor receptor superfamily member 27

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	50,538,211 - 50,572,294 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936635	1,303,858 - 1,337,868 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936635	1,303,855 - 1,335,766 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anodontia (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

ectodermal dysplasia 1 (ISO)

factor VIII deficiency (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

tooth agenesis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (IEA)

intrinsic apoptotic signaling pathway by p53 class mediator (IEA)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of JNK cascade (IEA)

tumor necrosis factor-mediated signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

signaling receptor activity (IEA)

transmembrane signaling receptor activity (IEA)

tumor necrosis factor receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Eda2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	50,538,211 - 50,572,294 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936635	1,303,858 - 1,337,868 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936635	1,303,855 - 1,335,766 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EDA2R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	66,595,637 - 66,639,269 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	66,595,637 - 66,639,298 (-)	Ensembl			hg38	GRCh38
GRCh37	X	65,815,479 - 65,859,111 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	65,732,204 - 65,752,598 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	65,598,503 - 65,618,894	NCBI
Celera	X	66,163,047 - 66,183,441 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI
HuRef	X	59,642,932 - 59,686,455 (-)	NCBI		HuRef
CHM1_1	X	65,708,158 - 65,751,820 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	65,023,365 - 65,067,011 (-)	NCBI		T2T-CHM13v2.0

Eda2r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	96,375,936 - 96,420,786 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	96,377,446 - 96,420,822 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	97,333,837 - 97,377,234 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	97,333,840 - 97,377,216 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	94,529,180 - 94,572,548 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	93,538,638 - 93,579,891 (-)	NCBI		MGSCv36	mm8
Celera	X	84,324,759 - 84,367,800 (-)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	42.74	NCBI

Eda2r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	66,225,557 - 66,280,674 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	66,236,111 - 66,280,663 (-)	Ensembl				GRCr8
mRatBN7.2	X	62,224,763 - 62,269,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	62,228,229 - 62,269,268 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	63,691,820 - 63,736,363 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	67,192,369 - 67,236,902 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	64,755,977 - 64,800,507 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	66,560,200 - 66,602,509 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	66,561,286 - 66,602,506 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	67,389,639 - 67,430,026 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	85,010,195 - 85,049,670 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	62,627,786 - 62,667,518 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

Eda2r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	6,087,687 - 6,143,432 (-)	Ensembl
ChiLan1.0	NW_004955475	6,080,153 - 6,143,339 (-)	NCBI	ChiLan1.0	ChiLan1.0

EDA2R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	66,194,757 - 66,239,254 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	66,198,397 - 66,242,834 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	55,786,361 - 55,830,798 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	65,851,559 - 65,894,775 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	65,850,306 - 65,894,975 (-)	Ensembl			panPan2	panpan1.1

EDA2R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	52,522,231 - 52,533,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EDA2R
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	56,527,838 - 56,574,646 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	56,531,860 - 56,574,448 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666083	3,894,520 - 3,942,652 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eda2r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624898	657,924 - 676,365 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624898	643,941 - 679,421 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021733155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040282161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000008358 ⟹ ENSSTOP00000007491

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936635	1,303,858 - 1,337,868 (+)	Ensembl

RefSeq Acc Id:

XM_021733157 ⟹ XP_021588832

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	50,538,211 - 50,572,294 (+)	NCBI
SpeTri2.0	NW_004936635	1,318,420 - 1,335,754 (+)	NCBI

Sequence:

show sequence

ACCATGGATTGCCAAGAAAATGAATACCAGGACCAATGGGGACGGTGCGTCACATGCCAACAGT
GTGGTCCTGGACAAGAGCTCTCCAAGGATTGTGGTTATGGAGAGGGTGGAGATGCATACTGTAC
AGCTTGCCCTCCTCGAAGGTACAAAAGCAGTTGGGGCCATCACAGATGTCAGACTTGCATTACC
TGCGCCATCATCAATCGTGTCCAGAAGGCCAACTGTACAGCTACCTCTAATGCAGTCTGTGGGG
ACTGTCTGCCCAGGTTCTACCGAAAGACACGCATTGGAGGGCTACAGGACCAAGAGTGCATCCC
ATGCACAAAGCAGACCCCCACCTCTGAGGTTCAGTGTGCCTTCCAGTTGAGCTTAGTGAAGGCA
GATGCACCCACAGTGCCCCCTCAGGAGGCCACACTTGTTGCACTGGTGAGCAGTCTGCTAGTGG
TGTTTACCCTGGCCTTCCTGGGGCTCTTCTTCCTCTACTGCAAGCAGTTCTTCAACAGACATTG
CCAGCGTGTTGCAGGAGGTTCGTTGCAGTTTGAGGCTGACGAAGCAGTGGAGGAGGAATCTCTT
TTCCCCGTGCCACCTGGCCAGGAGACCAGTCCTGAGTCCCCAGTGAGTGAGAGCATCTTTGAGA
CCCAGCCACTTAACCCCATCCTGGATGACGACTGCAGCTCGACTCGTGGCTTCCCCACACAGGA
GTCATTTACCGTGGCCTCCTGTGCCTCAGAGAGCCACTCCCACTGGGTCCACACCCCCATCGAA
TGCACAGAGCTGGACCTACAAAAGTTTTCCAGCTCTGCCTCCTGTACTGGAACCGAAAACTTGG
GTGGGAATACAACTGACAGCGTTGGAGACAGGCGGGAGCTCAATGTGCCCTATGAAGTTCCTAG
CCCTTAA

hide sequence

RefSeq Acc Id:

XM_040282161 ⟹ XP_040138095

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	50,538,211 - 50,572,294 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_021588832	(Get FASTA)	NCBI Sequence Viewer
	XP_040138095	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007491.3
GenBank Protein	KAG3272413	(Get FASTA)	NCBI Sequence Viewer
	KAG3272414	(Get FASTA)	NCBI Sequence Viewer
	KAG3272415	(Get FASTA)	NCBI Sequence Viewer
	KAG3272416	(Get FASTA)	NCBI Sequence Viewer
	KAG3272417	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021588832 ⟸ XM_021733157

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDCQENEYQDQWGRCVTCQQCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQTCITC
AIINRVQKANCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVKAD
APTVPPQEATLVALVSSLLVVFTLAFLGLFFLYCKQFFNRHCQRVAGGSLQFEADEAVEEESLF
PVPPGQETSPESPVSESIFETQPLNPILDDDCSSTRGFPTQESFTVASCASESHSHWVHTPIEC
TELDLQKFSSSASCTGTENLGGNTTDSVGDRRELNVPYEVPSP

hide sequence

RefSeq Acc Id:	XP_040138095 ⟸ XM_040282161
- Peptide Label:	isoform X2
- UniProtKB:	I3MBH5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000007491 ⟸ ENSSTOT00000008358

Protein Domains

TNFR-Cys

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008369	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008358.3	UniProtKB/TrEMBL
Gene3D-CATH	Tumor Necrosis Factor Receptor, subunit A, domain 2	UniProtKB/TrEMBL
InterPro	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	TNFR/NGFR_Cys_rich_reg	UniProtKB/TrEMBL
	TNFR_27	UniProtKB/TrEMBL
	TNFRSF27_N	UniProtKB/TrEMBL
	TNR19/27/EDAR	UniProtKB/TrEMBL
NCBI Gene	Eda2r	ENTREZGENE
PANTHER	PTHR12120:SF8	UniProtKB/TrEMBL
	TNFR-CYS DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	TNFR_c6	UniProtKB/TrEMBL
PRINTS	TNFACTORR27	UniProtKB/TrEMBL
PROSITE	TNFR_NGFR_1	UniProtKB/TrEMBL
	TNFR_NGFR_2	UniProtKB/TrEMBL
SMART	TNFR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/TrEMBL
UniProt	I3MBH5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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