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Gene: Aqp5 (aquaporin 5) Ictidomys tridecemlineatus

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Symbol:

Aqp5

Name:

aquaporin 5

RGD ID:

12567145

Description:

ENCODES a protein that exhibits channel activity (inferred); identical protein binding (inferred); water channel activity (inferred); INVOLVED IN camera-type eye morphogenesis (inferred); carbon dioxide transport (inferred); cellular hypotonic response (inferred); PARTICIPATES IN E-cadherin signaling pathway; water transport pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Bothnian type palmoplantar keratoderma (ortholog); brain ischemia (ortholog); FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aquaporin-5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP5 (aquaporin 5)	NCBI	Ortholog
Mus musculus (house mouse):	Aqp5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Aqp5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aqp5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AQP5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp5 (aquaporin 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	65,521,588 - 65,525,295 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	7,639,668 - 7,642,756 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	7,639,518 - 7,643,242 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

Bothnian type palmoplantar keratoderma (ISO)

brain ischemia (ISO)

Diaphragmatic Hernia (ISO)

dry eye syndrome (ISO)

hypohidrosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

camera-type eye morphogenesis (IEA)

carbon dioxide transport (IEA)

cellular hypotonic response (IEA)

odontogenesis (IEA)

pancreatic juice secretion (IEA)

protein homotetramerization (IEA)

saliva secretion (IEA)

transmembrane transport (IEA)

water transport (IEA)

Cellular Component

apical plasma membrane (IEA,ISO)

basal plasma membrane (IEA)

cytoplasmic vesicle (IEA)

cytoplasmic vesicle membrane (IEA)

endoplasmic reticulum (IEA)

membrane (IEA)

microvillus (IEA)

plasma membrane (IEA,ISO)

Molecular Function

channel activity (IEA)

identical protein binding (IEA)

protein binding (ISO)

water channel activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

water transport pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aqp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	65,521,588 - 65,525,295 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	7,639,668 - 7,642,756 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	7,639,518 - 7,643,242 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	49,961,872 - 49,965,682 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	49,961,872 - 49,965,682 (+)	Ensembl			hg38	GRCh38
GRCh37	12	50,355,655 - 50,359,465 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	48,641,546 - 48,645,227 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	48,641,545 - 48,645,227	NCBI
Celera	12	49,151,383 - 49,155,562 (+)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	47,386,849 - 47,390,948 (+)	NCBI		HuRef
CHM1_1	12	50,321,440 - 50,325,624 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	49,924,863 - 49,928,671 (+)	NCBI		T2T-CHM13v2.0

Aqp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	99,488,909 - 99,492,710 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	99,488,663 - 99,492,710 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	99,591,028 - 99,594,829 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	99,590,782 - 99,594,829 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	99,421,459 - 99,425,260 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	99,418,814 - 99,422,856 (+)	NCBI		MGSCv36	mm8
Celera	15	101,746,743 - 101,750,221 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.13	NCBI

Aqp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	132,601,528 - 132,605,060 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	132,601,059 - 132,605,062 (+)	Ensembl				GRCr8
mRatBN7.2	7	130,722,675 - 130,726,207 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,721,748 - 130,726,209 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	132,526,264 - 132,529,796 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,751,843 - 134,755,375 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,664,370 - 134,667,902 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,249,044 - 141,252,576 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,249,044 - 141,252,578 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	115,753,747 - 115,757,279 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,337,725 - 138,341,257 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	127,204,033 - 127,207,565 (+)	NCBI		Celera
RGSC_v3.1	7	138,414,167 - 138,417,694 (+)	NCBI
Cytogenetic Map	7	q36	NCBI

Aqp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	558,927 - 564,376 (+)	Ensembl
ChiLan1.0	NW_004955547	558,296 - 562,455 (+)	NCBI	ChiLan1.0	ChiLan1.0

AQP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	44,223,016 - 44,226,823 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	44,219,778 - 44,223,584 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	38,789,505 - 38,793,305 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	39,683,503 - 39,687,772 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	39,684,008 - 39,687,127 (-)	Ensembl			panPan2	panpan1.1

AQP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	4,735,313 - 4,742,975 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	4,735,538 - 4,737,650 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	41,517,676 - 41,521,418 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	4,785,875 - 4,789,618 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	27	4,750,857 - 4,754,598 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	4,740,684 - 4,744,421 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	41,912,308 - 41,916,050 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

AQP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	15,876,407 - 15,880,067 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	15,876,527 - 15,879,608 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	16,079,774 - 16,082,855 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	46,190,504 - 46,195,461 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	199,926,134 - 199,930,017 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	2,326,010 - 2,329,544 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624816	2,326,059 - 2,329,525 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000011259 ⟹ ENSSTOP00000010100

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936512	7,639,668 - 7,642,756 (+)	Ensembl

RefSeq Acc Id:

XM_005325110 ⟹ XP_005325167

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	65,521,588 - 65,525,295 (-)	NCBI
SpeTri2.0	NW_004936512	7,639,518 - 7,643,242 (+)	NCBI

Sequence:

show sequence

CCCCTGGCCGGCCCGCGCCAGGCAGCCAGCCACGGAGTGGGCGCTAGAGAGCGCGCGGCGCCTC
GCAGCCAGACCCCTGCCCCCGCCGCCTCCACTGCCCGAACGGCCGCCCCTTGTCGCGGCCTTTG
CCGCCGGGCCCCCAAGGCCACCATGAAGACAGAGGTGTGCTCCGTGGCCTTCCTCAAGGCCGTG
TTTGCAGAGTTCCTGGCCACCCTCATCTTCGTTTTCTTCGGCCTCGGCTCAGCCCTCAAGTGGC
CATCTGCACTGCCCTCCATTCTGCAGATCTCCATGGCCTTTGGTCTGGCCATAGGCACTATGGC
CCAGGCCCTGGGGCCCGTGAGCGGGGGCCACATCAACCCTGCCATCACCCTGGCCCTCTTAATA
GGCAACCAGATCTCACTGCTCCGGGCTATCTTCTACGTGGCAGCCCAGCTGGTGGGTGCCATCG
CCGGGGCAGGCATCCTCTATGCGCTGGTGCCGACCAATGCCCGGGGCAACCTGGCAGTCAACGC
GATCAACAACAACACAACGCCAAGCCAGGCTGTGGCAGTGGAGCTCATTCTCACCTTCCAGCTG
GCACTCTGCATCTTCTCCTCCACTGACTCCCGCCGCACCAGCCCTGTGGGCTCTCCAGCTCTAT
CCATTGGCCTGTCTGTCACGCTGGGCCACCTTGTAGGGATCTACTTCACCGGCTGCTCCATGAA
CCCAGCCCGCTCTTTTGGCCCCGCAGTGGTCATGAATCGGTTCAGCCCCTCACACTGGGTCTTC
TGGGTGGGGCCCATCGTGGGGGCCACCATGGCTGCCATCCTCTACTTCTACCTGCTCTTCCCTA
CCTCCCTGAGCCGCAGTGATCGTATTGCAGTCATCAAAGGCACCTATGAGCCAGAGAACATCGG
AAGAGTATAGAGCTGACCGCCCACTGACCAGCATCAGGCAGGGACAGCCCCTGAACCACAGAAG
AAAAAAGAAGAAAACTATGACAACGAAGCTTCCTTCTCTTGACTGGGGAGGAGGTGCTGGCTTC
CTGGGCTGCACAGTTAGAGATGGGAGCAGGACCCCATGATCAAATGCTCCAGTGGGGTCAGTGG
CTGGGGTCTGGTGGGAACAGGGTCTCTTTGGGACAGGGCAGATTGTGCTGCTGTGGGGTCAGAC
CTTGGAGATTGTGAGCATGATGCCAAGCTCGCTGACTGCTTCAGGGTCAGGCCAGAAAACAGAG
GCTGCTATCTGCTCCCCACACCTGCAGACCCTCAAGAGCTAGAACCAGGCCTTTGGTGTGGAGA
GTGGACCCTCCCCCAAAGCTCCTTAGTAGACTGATTCATTGAATGCCATCTTATTTATTTCTGA
TCAAGGATGCACGGGTGAGCTGCTGCTGTTTGGGTTGGGGGCTTCCTAATAAACCAATGATCTC
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325167	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010100.3
GenBank Protein	KAG3292005	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325167 ⟸ XM_005325110

- UniProtKB:

I3MGZ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKTEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPSILQISMAFGLAIGTMAQALGPVS
GGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGAGILYALVPTNARGNLAVNAINNNTTP
SQAVAVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGP
AVVMNRFSPSHWVFWVGPIVGATMAAILYFYLLFPTSLSRSDRIAVIKGTYEPENIGRV

hide sequence

Ensembl Acc Id:

ENSSTOP00000010100 ⟸ ENSSTOT00000011259

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011261	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011259.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1080.10	UniProtKB/TrEMBL
InterPro	Aquaporin-like	UniProtKB/TrEMBL
	Aquaporin_5	UniProtKB/TrEMBL
	Aquaporin_transptr	UniProtKB/TrEMBL
	MIP	UniProtKB/TrEMBL
	MIP_CS	UniProtKB/TrEMBL
NCBI Gene	Aqp5	ENTREZGENE
PANTHER	PTHR19139	UniProtKB/TrEMBL
	PTHR19139:SF38	UniProtKB/TrEMBL
Pfam	MIP	UniProtKB/TrEMBL
PRINTS	AQUAPORIN5	UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/TrEMBL
PROSITE	MIP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF81338	UniProtKB/TrEMBL
UniProt	I3MGZ3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)