Hdac2 (histone deacetylase 2) - Rat Genome Database

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Gene: Hdac2 (histone deacetylase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Hdac2
Name: histone deacetylase 2
RGD ID: 12566838
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); deacetylase activity (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cardiac muscle cell development (ortholog); cardiac muscle cell proliferation (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); alcohol use disorder (ortholog); FOUND IN chromatin (ortholog); heterochromatin (ortholog); replication fork (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366792,448,390 - 2,474,641 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to ethanol  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy  (ISO)
cellular response to dopamine  (ISO)
cellular response to heat  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to trichostatin A  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
circadian regulation of gene expression  (ISO)
dendrite development  (ISO)
embryonic digit morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
eyelid development in camera-type eye  (ISO)
fungiform papilla formation  (ISO)
hair follicle placode formation  (ISO)
heterochromatin formation  (IEA)
hippocampus development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of peptidyl-lysine acetylation  (ISO)
negative regulation of transcription by competitive promoter binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of interleukin-1 production  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of male mating behavior  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of protein modification process  (ISO)
positive regulation of proteolysis  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
progesterone receptor signaling pathway  (ISO)
protein deacetylation  (ISO)
protein modification process  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of protein deacetylation  (ISO)
regulation of sarcomere organization  (ISO)
response to alcohol  (ISO)
response to amphetamine  (ISO)
response to amyloid-beta  (ISO)
response to caffeine  (ISO)
response to cocaine  (ISO)
response to hyperoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to xenobiotic stimulus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Hdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366792,448,390 - 2,474,641 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6113,933,028 - 114,011,308 (-)EnsemblGRCh38hg38GRCh38
GRCh376114,254,192 - 114,292,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
T2T-CHM13v2.06115,116,117 - 115,154,233 (-)NCBIT2T-CHM13v2.0
Hdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,850,293 - 36,877,885 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1036,850,540 - 36,877,885 (+)EnsemblGRCm39 Ensembl
GRCm381036,974,297 - 37,001,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,974,544 - 37,001,889 (+)EnsemblGRCm38mm10GRCm38
MGSCv371036,694,350 - 36,721,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361036,663,960 - 36,691,304 (+)NCBIMGSCv36mm8
Celera1037,867,952 - 37,895,247 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.44NCBI
Hdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,101,815 - 42,126,486 (+)NCBIGRCr8
mRatBN7.22040,548,244 - 40,571,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2042,287,370 - 42,310,647 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,946,582 - 41,969,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,695,816 - 42,719,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Celera2041,298,790 - 41,322,159 (+)NCBICelera
Cytogenetic Map20q12NCBI
Hdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,728,377 - 2,759,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555262,739,099 - 2,759,640 (+)NCBIChiLan1.0ChiLan1.0
HDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25133,936,717 - 133,967,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16131,832,186 - 131,863,124 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06111,731,139 - 111,761,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16115,802,367 - 115,833,004 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,802,367 - 115,833,004 (-)Ensemblpanpan1.1panPan2
HDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,053,822 - 70,083,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,053,297 - 70,103,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1269,799,259 - 69,828,714 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01270,933,049 - 70,962,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1270,932,535 - 70,961,523 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11270,285,352 - 70,314,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01270,123,758 - 70,153,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01270,454,633 - 70,484,021 (-)NCBIUU_Cfam_GSD_1.0
HDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,863,094 - 79,901,585 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,929,206 - 89,962,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,873,248 - 59,904,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1359,873,767 - 59,905,742 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604032,233,290 - 32,264,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,834,217 - 4,861,592 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248564,834,197 - 4,861,546 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005337424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000012782   ⟹   ENSSTOP00000011457
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366792,448,390 - 2,474,641 (-)Ensembl
RefSeq Acc Id: XM_005337424   ⟹   XP_005337481
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBI
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005337481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011457.2
GenBank Protein KAG3290089 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005337481   ⟸   XM_005337424
- UniProtKB: I3MJS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000011457   ⟸   ENSSTOT00000012782
Protein Domains
Histone deacetylase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012779 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012782.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
InterPro HDAC_PDAC UniProtKB/TrEMBL
  His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_dom_sf UniProtKB/TrEMBL
NCBI Gene Hdac2 ENTREZGENE
PANTHER HISTONE DEACETYLASE 2 UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/TrEMBL
PIRSF His_deacetylse_1 UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt I3MJS8 ENTREZGENE, UniProtKB/TrEMBL