Traf3ip2 (TRAF3 interacting protein 2) - Rat Genome Database

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Gene: Traf3ip2 (TRAF3 interacting protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Traf3ip2
Name: TRAF3 interacting protein 2
RGD ID: 12561316
Description: ENCODES a protein that exhibits signaling receptor binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN B cell affinity maturation (inferred); B cell apoptotic process (inferred); B cell homeostasis (inferred); ASSOCIATED WITH atopic dermatitis (ortholog); Candidiasis, Familial, 8 (ortholog); Discoid Lupus Erythematosus (ortholog); FOUND IN cytoplasmic vesicle (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adapter protein CIKS; E3 ubiquitin ligase TRAF3IP2; TRAF3 interacting protein 2, transcript variant X1; TRAF3 interacting protein 2, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,076,436 - 103,116,386 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679316,277 - 336,557 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679308,508 - 348,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell affinity maturation  (IEA)
B cell apoptotic process  (IEA)
B cell homeostasis  (IEA)
B cell mediated immunity  (IEA)
CD40 signaling pathway  (IEA)
cellular response to cytokine stimulus  (IEA)
cellular response to interleukin-17  (IEA)
cytokine-mediated signaling pathway  (IEA)
eosinophil homeostasis  (IEA)
eosinophil mediated immunity  (IEA)
establishment of T cell polarity  (IEA)
gene expression  (IEA)
heart development  (IEA)
humoral immune response  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
interleukin-17-mediated signaling pathway  (IEA)
interleukin-17A-mediated signaling pathway  (IEA)
kidney development  (IEA)
leukocyte activation involved in inflammatory response  (IEA)
lymph node development  (IEA)
mRNA stabilization  (IEA)
mucus secretion  (IEA)
neutrophil activation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of defense response to virus by host  (IEA)
protein import into nucleus  (IEA)
protein K63-linked ubiquitination  (IEA)
protein localization to nucleus  (IEA)
protein localization to P-body  (IEA)
protein polyubiquitination  (IEA)
protein ubiquitination  (IEA)
response to cytokine  (IEA)
response to xenobiotic stimulus  (IEA)
signal transduction involved in regulation of gene expression  (IEA)
skin development  (IEA)
spleen development  (IEA)
T cell activation  (IEA)
T cell differentiation  (IEA)
T-helper 17 type immune response  (IEA)
transitional two stage B cell differentiation  (IEA)
tumor necrosis factor-mediated signaling pathway  (IEA)
type 2 immune response  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Traf3ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,076,436 - 103,116,386 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679316,277 - 336,557 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679308,508 - 348,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAF3IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386111,555,381 - 111,605,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6111,555,381 - 111,606,906 (-)EnsemblGRCh38hg38GRCh38
GRCh376111,876,584 - 111,927,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,986,836 - 112,034,014 (-)NCBINCBI36Build 36hg18NCBI36
Build 346111,986,835 - 112,034,014NCBI
Celera6112,626,739 - 112,674,049 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,448,986 - 109,500,061 (-)NCBIHuRef
CHM1_16112,139,458 - 112,190,300 (-)NCBICHM1_1
T2T-CHM13v2.06112,738,381 - 112,788,887 (-)NCBIT2T-CHM13v2.0
Traf3ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391039,488,930 - 39,531,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1039,488,930 - 39,531,303 (+)EnsemblGRCm39 Ensembl
GRCm381039,612,934 - 39,655,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,612,934 - 39,655,307 (+)EnsemblGRCm38mm10GRCm38
MGSCv371039,332,740 - 39,375,113 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361039,302,350 - 39,344,723 (+)NCBIMGSCv36mm8
Celera1040,498,927 - 40,541,335 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.86NCBI
Traf3ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,565,992 - 44,609,240 (+)NCBIGRCr8
mRatBN7.22043,011,405 - 43,054,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,011,450 - 43,054,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,760,488 - 44,803,525 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,419,713 - 44,462,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,161,986 - 45,205,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,679,861 - 44,722,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,680,449 - 44,722,872 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,401,898 - 46,445,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,747,622 - 43,792,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2043,727,541 - 43,769,944 (+)NCBICelera
Cytogenetic Map20q12NCBI
Traf3ip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541136,326,926 - 36,363,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541136,328,152 - 36,363,614 (-)NCBIChiLan1.0ChiLan1.0
TRAF3IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25131,572,937 - 131,620,512 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,458,898 - 129,506,170 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,367,333 - 109,414,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,443,540 - 113,490,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,444,005 - 113,485,533 (-)Ensemblpanpan1.1panPan2
TRAF3IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,029,861 - 68,070,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,030,197 - 68,058,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,849,673 - 67,891,354 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,911,754 - 68,953,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,911,760 - 68,952,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,263,251 - 68,304,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,109,790 - 68,151,470 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,435,643 - 68,477,316 (-)NCBIUU_Cfam_GSD_1.0
TRAF3IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl177,487,577 - 77,541,198 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1177,483,997 - 77,541,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,044,462 - 87,102,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAF3IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,272,893 - 62,320,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1362,285,589 - 62,324,312 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,579,431 - 34,626,946 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Traf3ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624933506,254 - 554,015 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624933507,879 - 558,357 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000040072   ⟹   ENSSTOP00000024348
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936679316,277 - 336,557 (-)Ensembl
RefSeq Acc Id: XM_005337418   ⟹   XP_005337475
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946103,076,436 - 103,116,386 (-)NCBI
SpeTri2.0NW_004936679308,508 - 348,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283221   ⟹   XP_040139155
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946103,076,436 - 103,088,005 (-)NCBI
RefSeq Acc Id: XM_040283222   ⟹   XP_040139156
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946103,076,436 - 103,084,131 (-)NCBI
RefSeq Acc Id: XM_040283223   ⟹   XP_040139157
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946103,076,436 - 103,083,488 (-)NCBI
RefSeq Acc Id: XP_005337475   ⟸   XM_005337418
- Peptide Label: isoform X1
- UniProtKB: A0A287CSV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139155   ⟸   XM_040283221
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040139156   ⟸   XM_040283222
- Peptide Label: isoform X3
- UniProtKB: I3M728 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139157   ⟸   XM_040283223
- Peptide Label: isoform X3
- UniProtKB: I3M728 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000024348   ⟸   ENSSTOT00000040072
Protein Domains
SEFIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005987 UniProtKB/TrEMBL
  ENSSTOG00000031707 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005986.3 UniProtKB/TrEMBL
  ENSSTOT00000040072.1 UniProtKB/TrEMBL
InterPro E3_ubiq_ligase_TRAF3IP2 UniProtKB/TrEMBL
  SEFIR_dom UniProtKB/TrEMBL
NCBI Gene Traf3ip2 ENTREZGENE
PANTHER ADAPTER PROTEIN CIKS UniProtKB/TrEMBL
  E3 UBIQUITIN LIGASE TRAF3IP2 UniProtKB/TrEMBL
Pfam SEFIR UniProtKB/TrEMBL
PROSITE SEFIR UniProtKB/TrEMBL
UniProt A0A287CSV9 ENTREZGENE, UniProtKB/TrEMBL
  I3M728 ENTREZGENE, UniProtKB/TrEMBL