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Gene: Kdf1 (keratinocyte differentiation factor 1) Ictidomys tridecemlineatus

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Symbol:

Kdf1

Name:

keratinocyte differentiation factor 1

RGD ID:

12561194

Description:

INVOLVED IN negative regulation of stem cell proliferation (ortholog); ASSOCIATED WITH anodontia (ortholog); ectodermal dysplasia 12 (ortholog); genetic disease (ortholog); FOUND IN cell cortex (inferred); cell junction (inferred); cell leading edge (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	45,517,294 - 45,526,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	11,343,539 - 11,351,168 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	11,341,415 - 11,351,066 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anodontia (ISO)

ectodermal dysplasia 12 (ISO)

genetic disease (ISO)

retinitis pigmentosa 59 (ISO)

tooth agenesis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

developmental growth (IEA)

epidermal cell differentiation (IEA)

establishment of skin barrier (IEA)

keratinocyte development (IEA)

keratinocyte proliferation (IEA)

limb epidermis development (IEA)

morphogenesis of embryonic epithelium (IEA)

negative regulation of keratinocyte proliferation (IEA)

negative regulation of stem cell proliferation (IEA,ISO)

positive regulation of epidermal cell differentiation (IEA)

protein deubiquitination (IEA)

protein stabilization (IEA)

regulation of epidermal cell division (IEA)

skin development (IEA)

stem cell proliferation (IEA)

Cellular Component

cell cortex (IEA)

cell junction (IEA)

cell leading edge (IEA)

cytoplasm (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Kdf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	45,517,294 - 45,526,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	11,343,539 - 11,351,168 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	11,341,415 - 11,351,066 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KDF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,949,562 - 26,960,468 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,949,562 - 26,960,468 (-)	Ensembl			hg38	GRCh38
GRCh37	1	27,276,053 - 27,286,959 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	27,148,648 - 27,159,484 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	25,673,140 - 25,683,994 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	25,529,626 - 25,540,470 (-)	NCBI		HuRef
CHM1_1	1	27,389,393 - 27,400,245 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	26,787,618 - 26,798,705 (-)	NCBI		T2T-CHM13v2.0

Kdf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	133,246,274 - 133,258,101 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	133,246,274 - 133,258,101 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	133,518,733 - 133,530,790 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	133,518,963 - 133,530,790 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	133,074,878 - 133,086,705 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,791,111 - 132,802,866 (+)	NCBI		MGSCv36	mm8
Celera	4	131,688,107 - 131,699,976 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.25	NCBI

Kdf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,028,152 - 151,039,753 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	151,029,149 - 151,039,752 (+)	Ensembl				GRCr8
mRatBN7.2	5	145,744,753 - 145,758,150 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	145,745,099 - 145,755,878 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	148,447,139 - 148,457,927 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,216,744 - 150,227,530 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,203,304 - 150,214,086 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	151,740,902 - 151,752,863 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	151,741,817 - 151,752,597 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	155,430,208 - 155,442,122 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	5	144,165,183 - 144,176,199 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Kdf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	6,280,391 - 6,289,608 (-)	Ensembl
ChiLan1.0	NW_004955452	6,280,391 - 6,288,985 (-)	NCBI	ChiLan1.0	ChiLan1.0

KDF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,910,727 - 199,921,937 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,014,873 - 199,029,610 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,210,572 - 26,221,991 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,267,106 - 27,277,713 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,267,106 - 27,277,684 (-)	Ensembl			panPan2	panpan1.1

KDF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,198,278 - 73,206,691 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,197,580 - 73,207,153 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,776,306 - 69,784,741 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,761,802 - 73,770,459 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,767,812 - 73,769,916 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	70,587,054 - 70,595,485 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	71,592,397 - 71,600,846 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	72,595,415 - 72,603,855 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

KDF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,254,499 - 84,265,041 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	84,254,493 - 84,265,112 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	77,824,691 - 77,835,315 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KDF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,803,540 - 105,814,461 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,811,182 - 105,816,004 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	10,618,673 - 10,630,514 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kdf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	10,927,931 - 10,936,670 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	10,927,426 - 10,936,771 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021734589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000015233 ⟹ ENSSTOP00000013652

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	11,343,539 - 11,351,168 (-)	Ensembl

RefSeq Acc Id:

XM_021734589 ⟹ XP_021590264

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	45,517,294 - 45,526,324 (-)	NCBI
SpeTri2.0	NW_004936474	11,341,415 - 11,351,066 (-)	NCBI

Sequence:

show sequence

GAAGGGGGCGGGGGAAGCGCTGAGCCGGAGGCCGCTCACCTGGCGGGACAGGCAGGTACCTGGC
TGCAGGAGACCATGCAGTGAGCCATGCCCCGGCCAGGACAGCCCCGCCCATTATCTGGGCCACC
TCGCTTGGGACCCTGGGAGCAGCCAACAGAGCTATGCTTGGAGGCGTATAATGAAACACCGCAG
CACCCACCAGGCCGCCGCACCCGGAGACCAGACCCCAAGGACCCTGGCCACCATGGGCCAGAGA
GCATTACCTTCATCTCGGGCTCTGCAGAGCCTGCCACAGAGCCCCCAGCCTGCTGCCTGCTCTG
GCGTCCCTGGGGGTGGGACTGGTGTCGGGCTGCTTTCTGCTTCCGCCGCTGCAGGGATTGCCTC
CAGCGCTGCGGGGCCTGTGTGCGGGGCTGCAGCCCCTGCTTGTCTGCTGGGGACTCCACCGAGG
AGGCTGCTGAGGCCAGCTGGGCCAAGGAGCACAATGGAGTACCCCCCAGCCCCGACCGCCCACC
CCCTAGCCGCCGGGATGGCCAGCGGCTCAAGTCTGCCGTGGGCAGCAGCTTCAGCTACCCTGAT
GTCAAGCTCAAAGGCGTCCCTGTGTACCCCTACCGCAGCACCACCTCCCCAGCTCCGGACTCGG
ACTCCTGCTGCAAGGAGCCACTGGCCCAGCCCCCTCCCACGCGGCACAGCCTGCCGAGCACCCT
TGCCAGCAGTCCCCGAGGCTCAGAGGAGTACTACTCTTTCCACGAGTCGGACCTGGACCTGCCG
GAGATGGGCAGCGGCTCCATGTCTAGCCGGGAAATCGACGTGCTCATATTCAAGAAGTTGACCG
AGCTGTTCAGCGTACACCAGATCGACGAGCTGGCCAAATGCACGTCGGACACGGTGTTCCTGGA
GAAGACCAGTAAGATCTCGGACCTGATCAGCAGCATCACGCAGGACTACCATCTGGACGAGCAG
GACGCGGAGGGCCGCCTGGTGCGCGGCATTATTCGCATTAGTACCCGAAAGAGCCGCGCCCGCC
CACAGACCTCAGAGGGGCGCTCCACCCGGGCTGCAGCCCCAGCTGCTGCCCCTGACAGTGGCCA
TGAGACTATGGTGGGCTCAGGTCTCAGCCAGGATGAACTGACAGTGCAGATCTCCCAGGAGACA
ACAGCAGATGCCATCGCCCGGAAGCTGCGGCCATATGGAACCCCAGGGTACCCAGCCAGCCATG
ACTCGGCCTTCCAGGGCACTGACACAGACTCCTCAGGGGCACCCCTGCTCCAGGTGTACTGCTA
ATCCCTTCTGGGTATAGCAGCACAACCCTTCTTGGGAGCAACGTAGCCTACAAAATAAAGAGGC
ATCAGGACCTTCTTTGAGGGAGGCTGGACTGTGAGGCCAGAAGCAGTGCCCACTCTAGCTCTTC
CTGCCTTCACTGACTGCTTCCTGGACCATGTGCATTTCACAGGGCCAAAGTGCCCACATCCCCA
GCTGGCCTGACCCCTGCCTGGACCTATTCCTTTCTGTGGATCGATCATGGAAAACAAAGACTTA
AAGTTATCTTCCAGGACTGAATCCCAACTCTGTCCTCGTAATGTCACCCTAAGCAGTCATCATT
GCAAACTTGAAGCTTAAGTAGACTGAGTTGTGGGTGGGCAGTGCCCACTTCACCTTATGCTGCT
GAGCAGTTTGTTCTAGCTAACCACCACAGTTGAAAGTACAAAGGTAATGGACTCCTATCTTATA
ATCTGGGCTACCACATAGTCCTTTCTGCCTGCTTTGCCTTGCCTAATGGCTGCCCAGGAGACAG
GACATGGGTATGAGGCTGGGCTGTGTGGCAGAGTTGAGGTCATGATGTGAAGCAATACTGCCTG
TGTTCCAAGAACAGTGTGGTACCTGAATAGCTTTTGGAGTTCTCAGTTCTAGGGGTGCTTGTTG
GCACCATCGCTGCTCCCCTTGTCCACTGCCTGCAGGGTGGCCTGTCAGCCATCCCAGTCCCCCC
AAATCCCTGATCATTTGTCAGCAGCCCCCACCCAGTTTAACCCTGCTGCTCCCCTCCACCTCTT
CCCTGTGCTAACAGCACAGTGGTTTTCAGTTACCTTGGCCTTTCTTGCAACCCTAGAGTATAAG
GGAACCTGGGGCTGAAAAGTCAAGGAATTAGTGGGTCACAGAGGTGGTAACTGCGGCTTTGGAC
CTGGAAGCTAACCTTGGGACAGCAAGAGGCTCCCCTTGCTTGGGCACCAGCATCCAGCCTATCC
TTCACTGCTCCTCAAACAGGCATGTCTAATAGGATCCTTTCAGCAGAGACTGGGGCAGGTCCAC
CAACCCATCTTAAACTAACAAACAAGCTGGAAGATGTCCATGGTCTTCCATTCCTACCCCTTTA
TCTGCAGCCCTTTTTATGTCCCCATGGGCACCCTTTGGAAAGTGACTAGACAAACTACTTGTTT
GTCCAGTTTCCTATTAGATACACAGGATACTCCCCTAGGGCTATGACCATGGGGCCCAGTTGTA
GCTCCTGCAGTCTAACTGGGCCCTTTCCTCAGGCTCTGTTGTCCCATCTAGGTCAAGGCCTGAG
AATAAAACCAGGCTGGGGTGTGTGTAGCTCAGTGGCAGCATTTGTCTAGTAGTCAGGTCCTCCC
TGGGTTTGATTTCCATCCAACCAACTGCAGAGCACCAGAGTAGGAGAGTGACACCAGTCCCTCC
ACTCCAGCCTCAGCCGTAAAACACCTTTTTCTAGTAAACAGCCTTGTGAACTATCATGTGCATT
CCCCCAAAACAGGATTTATCAAATTTGGGAAAGAGACAAAGGTAAGTGCCTGCAATGACCTCTA
CCCTCTGGCAGAAGCAGGGCAGGGCCAGCTAAAGGTCCTGGGGCTGGACAGAGGTAACATGTCC
TCAGCTCTGTTACTGCCTAGGGGCTGGCTCTGAGGCTTTAAAAACTGCACATGTCCAGATGAGA
GACAAAAACAGTAGGGCCTTACCAGACTTTAGCCTATACTTTAGGGCAGGTCCCTGTACTACAC
AGAACAAATCTAAGGCATGGGTGATCCCATCTCCCTCACCTGAGCTAGGCAGTGTCACCAAGGC
CTTGTTGCTCTTTTGCCCTGGGAAACAGTCCAGAGTTGGAAAAATACTTGATTCAGGGCTGGGG
GTGGTGGAGGGACTCTCAGAGATGAAAATAAAATCAATTAAGTCCAGCTGGCCTTAATCTTTGC
TGGTTCATGGGCTCCTTTGAGAATCTGACATACGTCTTGCTCTCTGTAGCCAGAAAAACTCTCC
TTTGCTTGGAGCCATACAGACTAAAAACCTTGTCCCAATCCTCCAAGAGAGGAGGAGAAATTGA
GGCCCCATGAGGGGCAAGGACTTGCTCTAGGTCACATGGCAGAATCTGGGCTAAAAGCCAAAAC
CCTATCTCCTAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_021590264	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013652.2
GenBank Protein	KAG3282508	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021590264 ⟸ XM_021734589

- UniProtKB:

I3MPE4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRPGQPRPLSGPPRLGPWEQPTELCLEAYNETPQHPPGRRTRRPDPKDPGHHGPESITFISGS
AEPATEPPACCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDSTEEAAEASWA
KEHNGVPPSPDRPPPSRRDGQRLKSAVGSSFSYPDVKLKGVPVYPYRSTTSPAPDSDSCCKEPL
AQPPPTRHSLPSTLASSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQI
DELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRARPQTSEGRS
TRAAAPAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGTPGYPASHDSAFQGTD
TDSSGAPLLQVYC

hide sequence

Ensembl Acc Id:

ENSSTOP00000013652 ⟸ ENSSTOT00000015233

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015233	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015233.3	UniProtKB/TrEMBL
InterPro	KDF1	UniProtKB/TrEMBL
NCBI Gene	Kdf1	ENTREZGENE
PANTHER	KERATINOCYTE DIFFERENTIATION FACTOR 1	UniProtKB/TrEMBL
	PTHR35085	UniProtKB/TrEMBL
Pfam	DUF4656	UniProtKB/TrEMBL
UniProt	I3MPE4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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