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Gene: Atp12a (ATPase H+/K+ transporting non-gastric alpha2 subunit) Ictidomys tridecemlineatus

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Symbol:

Atp12a

Name:

ATPase H+/K+ transporting non-gastric alpha2 subunit

RGD ID:

12553887

Description:

ENCODES a protein that exhibits P-type potassium:proton transporter activity (ortholog); INVOLVED IN response to metal ion (ortholog); ASSOCIATED WITH hypokalemia (ortholog); Metabolic Syndrome (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN apical plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

potassium-transporting ATPase alpha chain 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	120,815,441 - 120,830,841 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936720	2,363,933 - 2,378,426 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936720	2,363,933 - 2,378,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypokalemia (ISO)

Metabolic Syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment or maintenance of transmembrane electrochemical gradient (IEA)

intracellular potassium ion homeostasis (IEA)

intracellular sodium ion homeostasis (IEA)

monoatomic ion transport (IEA)

potassium ion homeostasis (IEA)

potassium ion import across plasma membrane (IEA)

potassium ion transport (IEA)

proton transmembrane transport (IEA)

regulation of pH (IEA)

response to metal ion (ISO)

sodium ion export across plasma membrane (IEA)

Cellular Component

actin cytoskeleton (IEA)

apical plasma membrane (IEA,ISO)

basolateral plasma membrane (IEA)

cytosol (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATPase-coupled monoatomic cation transmembrane transporter activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

P-type potassium transmembrane transporter activity (IEA)

P-type potassium:proton transporter activity (IEA,ISO)

P-type sodium:potassium-exchanging transporter activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Atp12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	120,815,441 - 120,830,841 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936720	2,363,933 - 2,378,426 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936720	2,363,933 - 2,378,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP12A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	24,680,408 - 24,712,472 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	24,680,408 - 24,712,472 (+)	Ensembl			hg38	GRCh38
GRCh37	13	25,254,546 - 25,286,610 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	24,152,695 - 24,183,918 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	24,152,694 - 24,183,909	NCBI
Celera	13	6,318,100 - 6,349,140 (+)	NCBI		Celera
Cytogenetic Map	13	q12.12	NCBI
HuRef	13	6,067,884 - 6,098,930 (+)	NCBI		HuRef
CHM1_1	13	25,223,064 - 25,254,444 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	23,888,443 - 23,920,536 (+)	NCBI		T2T-CHM13v2.0

Atp12a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	56,602,525 - 56,626,008 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	56,602,525 - 56,626,007 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	56,364,669 - 56,388,551 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	56,365,068 - 56,388,550 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	56,983,905 - 57,007,388 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	55,319,139 - 55,342,661 (+)	NCBI		MGSCv36	mm8
Celera	14	54,162,904 - 54,186,387 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Atp12a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	34,559,209 - 34,583,866 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	34,559,209 - 34,583,866 (+)	Ensembl				GRCr8
mRatBN7.2	15	30,443,571 - 30,468,229 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	30,443,571 - 30,468,229 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	32,434,949 - 32,459,608 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	33,585,588 - 33,610,251 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	31,843,686 - 31,868,345 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	36,561,306 - 36,590,171 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	36,565,495 - 36,590,171 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	40,419,506 - 40,444,086 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	35,295,274 - 35,321,453 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	30,164,486 - 30,189,115 (+)	NCBI		Celera
RGSC_v3.1	15	35,310,973 - 35,337,153 (+)	NCBI
Cytogenetic Map	15	p12	NCBI

Atp12a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955497	225,158 - 252,789 (+)	Ensembl
ChiLan1.0	NW_004955497	225,401 - 251,024 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP12A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	24,276,840 - 24,308,884 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	15,385,828 - 15,417,870 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	5,972,372 - 6,004,411 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	24,263,240 - 24,294,136 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	24,268,003 - 24,294,136 (+)	Ensembl			panPan2	panpan1.1

ATP12A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	18,753,192 - 18,779,781 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	18,753,872 - 18,779,831 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	18,779,443 - 18,805,985 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	18,891,731 - 18,918,495 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	18,892,411 - 18,918,565 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	18,753,678 - 18,780,440 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	18,765,635 - 18,792,406 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	18,822,596 - 18,849,151 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

ATP12A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	114,325 - 144,092 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	113,901 - 144,765 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	87,521,754 - 87,551,316 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP12A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	4,146,462 - 4,178,880 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	4,147,308 - 4,177,888 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666057	40,312,486 - 40,336,633 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp12a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624776	18,467,967 - 18,495,651 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624776	18,466,952 - 18,495,693 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000041045 ⟹ ENSSTOP00000027742

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936720	2,363,933 - 2,378,426 (-)	Ensembl

RefSeq Acc Id:

XM_005338636 ⟹ XP_005338693

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	120,815,441 - 120,830,841 (-)	NCBI
SpeTri2.0	NW_004936720	2,363,933 - 2,378,426 (-)	NCBI

Sequence:

show sequence

AAAGTCGTGGTTGGAGATGCCTCGGAAACTGCTCTTTTGAAATTCTCAGAGGTCATTTTGGGTG
ATGTGATGGAAATTAGAAAAAGAAACCGCAAAGTAGCTGAAATCCCTTTTAACTCTACGAACAA
ATTTCAGCTCTCCATACATGAGACAGAGGACCCCAACGACAAGCGCTTCCTCATGGTGATGAAA
GGGGCTCCCGAGAGGATCTTGGAGAAGTGCAGCACTATAATGATCAATGGTCAGGAGCAGCCAC
TGGACAAAAGCACCGCTGCGGAATTCCATACAGCCTACATGGAGCTGGGTGGGCTGGGCGAGCG
TGTGTTGGGTTTCTGTCATCTCTACCTGCCAGCAGACAAGTTTCCAGAGACCTACTCCTTTGAT
ATAGACACCATTAACTTTCCTACCTCCAACCTCTGTTTTGTGGGGCTCTTGTCGATGATAGATC
CCCCTCGGTCTACTGTGCCAGATGCAGTTACCAAATGCCGGAGTGCAGGGATCAAGGTTATTAT
GGTTACAGGTGATCATCCCATCACAGCCAAAGCTATTGCCAAGAGTGTAGGGATTATTTCAGCC
AACAGTGAAACAGTGGAAGACATTGCAAAACGCCTCAACATTGCTGTGGAGCAAGTTGACAAAC
GGGATGCTAAAGCTGCTGTGGTGACTGGCATGGAGCTGAAGGATATGAGCCCAGAACAGCTGGA
TGAGCTCTTAGCCAACTACCCAGAAATTGTCTTTGCCCGAACATCCCCTCAACAGAAGCTGATC
ATTGTGGAGGGTTGTCAGAGGCAGGATGCAGTTGTTGCTGTGACAGGAGATGGAGTAAATGATT
CTCCAGCTCTAAAGAAAGCAGACATTGGGATTGCCATGGGGATAGCAGGTTCTGATGCTGCCAA
AAATGCAGCCGACATGGTCTTGCTGGATGACAACTTTGCATCTATAGTCACAGGAGTGGAGGAA
GGCCGCCTGATTTTTGACAACCTAAAGAAGACTATTGCGTATACCCTGACCAAGAACATTGCTG
AACTTTGCCCCTTTTTGATCTACATCATTGTTGGGCTCCCTCTTCCCATTGGCACCATCACCAT
CCTGTTCATTGACCTGGGCACAGACATTATCCCCTCCATTGCCTTGGCATATGAGAAAGCTGAA
AGTGACATTATGAACAGGAAGCCTCGCCACAAGAAGAAAGACAGATTGGTAAACGAGCAACTTG
CCATCTACTCTTACCTGCACATTGGTCTCATGCAAGCCCTGGGAGCTTTCCTTGTATATTTCAC
TGTCTATGCACAAGAAGGCTTTTGGCCCACCTCTCTCATTAACCTACGGGTAGAATGGGAAAAA
GATGATATGAATGATTTAGAAGACAGCTATGGACAGGAATGGACAAGGTACCAGAGGAAATACT
TAGAGTGGACAGGATACACAGCCTTCTTTGTTGGCATCATGATCCAGCAAATAGCAGATCTGAT
CATCAGGAAAACTCGGAGAAATTCTATCTTCCAACAGGGGCTCTTCAGAAATAAAGTCATCTGG
GTGGGAATCGCCTCACAGATCATCATCGCACTGATCCTATCCTATGGCCTTGGGAGCGTCACAG
CCCTGAGTTTTACTATGCTTAGGCCTCAGTATTGGTTCGTGGCTATACCACATGCCATCTTGAT
TTGGGTGTATGATGAAGTGCGAAAACTCTTCATCAGGCTCTACCCTGGAAGCTGGTGGGATAAG
AATATGTACTATTAAGACCACATCACTCTCCACGTTTCCCAGTAGCATATTGGGAATATTCTTC
ATCTTCTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338693	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000027742.1
GenBank Protein	KAG3292855	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005338693 ⟸ XM_005338636

- UniProtKB:

A0A287D2J1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

KVVVGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHETEDPNDKRFLMVMK
GAPERILEKCSTIMINGQEQPLDKSTAAEFHTAYMELGGLGERVLGFCHLYLPADKFPETYSFD
IDTINFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISA
NSETVEDIAKRLNIAVEQVDKRDAKAAVVTGMELKDMSPEQLDELLANYPEIVFARTSPQQKLI
IVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEE
GRLIFDNLKKTIAYTLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAE
SDIMNRKPRHKKKDRLVNEQLAIYSYLHIGLMQALGAFLVYFTVYAQEGFWPTSLINLRVEWEK
DDMNDLEDSYGQEWTRYQRKYLEWTGYTAFFVGIMIQQIADLIIRKTRRNSIFQQGLFRNKVIW
VGIASQIIIALILSYGLGSVTALSFTMLRPQYWFVAIPHAILIWVYDEVRKLFIRLYPGSWWDK
NMYY

hide sequence

Ensembl Acc Id:

ENSSTOP00000027742 ⟸ ENSSTOT00000041045

Protein Domains

Cation-transporting P-type ATPase C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000033518	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000041045.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	Calcium-transporting ATPase, transmembrane domain	UniProtKB/TrEMBL
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/TrEMBL
	Cation_transp_ATPase_P-type	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	P-type_ATPase_IIC	UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/TrEMBL
KEGG Report	iti:101963004	UniProtKB/TrEMBL
NCBI Gene	Atp12a	ENTREZGENE
PANTHER	PTHR43294:SF1	UniProtKB/TrEMBL
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	UniProtKB/TrEMBL
Pfam	Cation_ATPase	UniProtKB/TrEMBL
	Cation_ATPase_C	UniProtKB/TrEMBL
	Hydrolase	UniProtKB/TrEMBL
PRINTS	NAKATPASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
UniProt	A0A287D2J1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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