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Gene: Gjc1 (gap junction protein gamma 1) Ictidomys tridecemlineatus

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Symbol:

Gjc1

Name:

gap junction protein gamma 1

RGD ID:

12527818

Description:

ENCODES a protein that exhibits gap junction channel activity (ortholog); INVOLVED IN cardiac muscle tissue development (ortholog); cell development (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); hypertension (ortholog); FOUND IN gap junction (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	17,990,495 - 18,016,917 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	1,178,493 - 1,182,967 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	1,177,581 - 1,182,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary breast ovarian cancer syndrome (ISO)

hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

AV node cell to bundle of His cell communication by electrical coupling (IEA)

cardiac muscle tissue development (IEA,ISO)

cell communication (IEA)

cell development (IEA,ISO)

cell-cell signaling (IEA,ISO)

chemical synaptic transmission (IEA,ISO)

gap junction assembly (IEA)

heart development (IEA,ISO)

monoatomic ion transmembrane transport (IEA)

transmembrane transport (IEA)

vasculogenesis (IEA,ISO)

visual perception (IEA,ISO)

Cellular Component

connexin complex (IEA)

endoplasmic reticulum (IEA)

gap junction (IEA,ISO)

nucleoplasm (IEA)

plasma membrane (IEA)

synapse (IEA)

Molecular Function

gap junction channel activity (IEA,ISO)

gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling (IEA)

monoatomic ion channel activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

connexin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gjc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	17,990,495 - 18,016,917 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	1,178,493 - 1,182,967 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	1,177,581 - 1,182,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GJC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	44,794,104 - 44,831,364 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	44,798,448 - 44,830,816 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	42,875,816 - 42,908,202 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	40,231,342 - 40,263,705 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	40,237,520 - 40,238,711	NCBI
Celera	17	39,586,320 - 39,618,684 (-)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	38,640,950 - 38,673,263 (-)	NCBI		HuRef
CHM1_1	17	43,111,947 - 43,144,318 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	45,648,941 - 45,685,306 (-)	NCBI		T2T-CHM13v2.0

Gjc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	102,690,303 - 102,710,512 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	102,690,405 - 102,710,526 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	102,799,477 - 102,819,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	102,799,579 - 102,819,700 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	102,660,792 - 102,681,000 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	102,615,669 - 102,620,731 (-)	NCBI		MGSCv36	mm8
Celera	11	114,511,245 - 114,530,176 (-)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	66.48	NCBI

Gjc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	88,262,840 - 88,285,646 (-)	NCBI		GRCr8
mRatBN7.2	10	87,758,192 - 87,785,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,867 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	92,799,858 - 92,820,614 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,266,006 - 92,286,621 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	87,659,342 - 87,679,956 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	90,781,408 - 90,912,440 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	90,781,402 - 90,912,287 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,573,861 - 90,576,546 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	10	90,684,903 - 90,685,231 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	86,466,836 - 86,488,023 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Gjc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	17,626,859 - 17,630,247 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	17,626,859 - 17,639,002 (-)	NCBI	ChiLan1.0	ChiLan1.0

GJC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	20,002,494 - 20,040,325 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	21,971,082 - 22,003,446 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	12,492,285 - 12,524,615 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	12,663,614 - 12,696,618 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	12,689,251 - 12,690,441 (+)	Ensembl	panpan1.1		panPan2

GJC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	18,642,359 - 18,688,128 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	18,686,527 - 18,687,717 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	18,071,974 - 18,073,164 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	19,336,722 - 19,382,385 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	19,337,429 - 19,382,482 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	18,234,973 - 18,235,559 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	18,416,349 - 18,417,539 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	18,573,413 - 18,574,603 (+)	NCBI		UU_Cfam_GSD_1.0

GJC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	18,526,595 - 18,560,218 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	18,526,060 - 18,560,221 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	18,770,695 - 18,795,440 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GJC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	61,575,851 - 61,596,488 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	61,594,885 - 61,596,075 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	32,322,168 - 32,350,709 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gjc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	461,691 - 464,454 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	443,234 - 466,222 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000013676 ⟹ ENSSTOP00000012255

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936541	1,178,493 - 1,182,967 (-)	Ensembl

RefSeq Acc Id:

XM_005328128 ⟹ XP_005328185

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	17,990,495 - 18,016,917 (+)	NCBI
SpeTri2.0	NW_004936541	1,177,581 - 1,182,967 (-)	NCBI

Sequence:

show sequence

TTGGCTGCTTCAGGGAATAGGGCACGCAGGGTGAAGAATTTTGCTAGGCCCTTAGGAACCGTTT
TCAGTTTGCTTGGATTCTTTTTTGGCTTTTTGCTATAGGTGCCAGAGTTTTCACAAATGACTCA
TCTTCCTCTCAGATTTTCTTAGGCTGCAGTGATTTAAGAATCTTTGGGTCACTGTTACATAGTT
TCTCCTACCACATGGATTGTGTGGGATAAAGTAGTCATATTGAAAGTCAAACCTGTTTCCATCT
CATTCTGAGTGATTCCTGTGGTACATAGAAAACTTTGTTTCTTCCTGAAAAATTATGTTTTAGT
GATTCGATGTTTTAGTGATTCATTGTTTTCTGTGGGTGGAAGTTTATCACCAACTCTTCTTTTT
CCCTTCCAGAAGGAATTTGGGAAAGTTGCAAGCAAAACATCATTTCTCAAAGAAGATTTTGGGT
AACAGAAGTTCTGCATAACAGGACAAACCAAGTTTATCACCATGAGTTGGAGCTTCCTGACTCG
CCTGCTAGAGGAGATTCACAACCATTCCACATTCGTAGGGAAGATCTGGCTCACTGTATTGATT
GTGTTTCGGATTGTCCTAACAGCTGTAGGAGGAGAGTCCATCTATTATGATGAGCAAAGCAAAT
TTGTGTGCAACACAGAACAGCCAGGCTGTGAGAATGTCTGCTATGATGCCTTTGCACCACTCTC
CCATGTGCGGTTCTGGGTGTTCCAGATCATTCTGGTGGCCACTCCCTCGGTGATGTACCTGGGC
TATGCCATTCATAAGATTGCCAAAATGGAGCATGGTGAGGCGGACAAGAAGGCGGCTCGGAGCA
AACCCTATGCTATGCGTTGGAAACAGCACCGGGCCCTGGAAGAAACAGAAGAGGACCATGAAGA
GGATCCCATGATGTATCCAGAAATGGAATTAGAAAGTGAAAAAGAAAATAAAGAACAGAGCCAA
CCGAAACCCAAGCATGATGGCCGACGACGGATTCGGGAGGATGGGCTCATGAAAATCTATGTAC
TACAGTTGCTGGCAAGGACCGTGTTTGAGGTGGGTTTTCTGATAGGGCAATATTTCCTGTATGG
CTTCCAAGTCCATCCATTTTATGTGTGCAGCAGACTTCCTTGCCCTCATAAAATAGACTGCTTT
ATTTCTAGACCCACTGAAAAGACCATCTTCCTTCTGATAATGTATGGTGTTACAGGCCTCTGCC
TATTGCTTAACATTTGGGAGATGCTTCATTTAGGGTTTGGGACCATTCGAGACTCACTAAACAG
TAAAAGGAGGGAACTTGAAGATCCGGGTGCTTATAATTATCCTTTCACTTGGAATACACCATCT
GCTCCCCCTGGCTATAACATTGCTGTCAAACCAGATCAAATCCAGTACACCGAATTGTCCAATG
CTAAGATCGCCTATAAGCAAAACAAAGCCAACATCGCCCAGGAGCAGCAGTATGGCAGCCACGA
GGAGCACCTCCCAGCTGATCTGGAGACTCTGCAGCGGGAGATCAGAATGGCTCAGGAACGCTTG
GATCTAGCAATCCAGGCCTATAATCACCAAAACAACCCCCATGGTCCTCGCGAAAAAAAGGCCA
AAGTGGGGTCCAAAGCTGGGTCCAACAAAAGCAGTGTTAGTAGCAAATCAGGGGATGGGAAGAC
CTCCGTCTGGATTTAATCTTTGCTGGGCTTAAAACTTGGGCTTTTCATAGTTTATGGTAAGCAA
CGGCTCACTGAATAATGACTTCCATTGAGTAAACATTTGGCTCTGGTTATCTTCAGGGATGCTG
TTGGCTCATGATCCAAACTCAGGGGACTCTGAAGGTGGGGCTGAGATGAGTGGGGAAAGGGAAA
CACAGTGTTCCAGGGCACATGTTCTCAGCAATAATACAATTGCAGAACTTTACATTTGTGTCTT
CCAGATCCAGAGAAGAACAGATATATTTAAATCATTCTTGTTGAACAGTTTTTGTATGTACAGT
ATTATGGTACATTTTTTTTCTTTTTCTTTTTTTTTAGTATGAGAACTTTTTTGTATTTGTACAT
TGAACTGCTGTAGTTATACTTTTTTATATTAAAGGAAAAAAAATCCTTGTAAGTAATGCCTATT
AGGCTAGTGTTATTACTTTGTTTAGCAAAATCTACCCTGGGTTTAGAGTTTTAGTAGATGCTAC
ATTCAATACAAGTGCCTCTCATGTTGCAGGGAACATTTCAATGGAGACTGAGGAGGAGATACCA
GTTTTCTGTCTTAGAAAGGAAGACTACATTAGAAAGAGATTGAGATCTTCTCTCTTCTACCTGA
GAAATCTGGGAATCTCAACTTTTATAACCAGAGCTGTAGCCATTCTTTGAAAACATGTTTCCAA
GGGAAGTAAATAATTAGCTGCAGGATTTCTTCAAATTCCAAGCATTGCCAATATGTGCTTTGAT
GTTATATACATAAGTTCTTTCAAAAAACTGATATGCAGTGGTGTCCCCCATCTAGTAGCTACAT
TCAATATAAGTGCCCAGGAGCAGTATGAAGCGCCTGGCTAGATTTTGGTGCTAAGCTGCTTGTC
TCAGAGAGCTCAGTCGCGCCTGGGAAATGAGGCCTAATAGGATGTTTAGCTGTGAACCCTTTTG
ATTGGCTTTAAGCCTCAATCCAGAAATCTGCCCATCTCTCTGGTTTCTTAAGCCAATAATGAAT
ATTTTCCGTACTTGTTAACATTAGAAATATAAAAATTCCCTTATAGACTAAGAATATTCAAAAC
TTCCTATACTGCAAATGGCAGAAGGCTTAAATCCAGATTTTTAAATTTCTTTTTATAATGGAAT
TTATGATTGACTTACTTCTGCCAATGTAGGTATCTGCCTAAGTGGCCATTCTCACTTGGGATTT
GTCTGTAAATAAACCAAAAGAGGTGTTCAGTATTTATTCCCTGTTGGTATATGTTATTTGTTAA
TGACAAGCATTATTGTTTATGAAACTAGTGTTTTATAAACAGTATTTATTGCCATCCTTTTTTT
TTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328185	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000012255.2
GenBank Protein	KAG3268791	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005328185 ⟸ XM_005328128

- UniProtKB:

I3MLG8 (UniProtKB/TrEMBL), A0A654ICH8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVC
YDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALE
ETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFL
IGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFG
TIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQ
EQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYNHQNNPHGPREKKAKVGSKAGSNKSSVS
SKSGDGKTSVWI

hide sequence

Ensembl Acc Id:

ENSSTOP00000012255 ⟸ ENSSTOT00000013676

Protein Domains

Connexin N-terminal Gap junction protein cysteine-rich

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000013682	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000013676.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1440.80	UniProtKB/TrEMBL
InterPro	Connexin	UniProtKB/TrEMBL
	Connexin45	UniProtKB/TrEMBL
	Connexin_CCC	UniProtKB/TrEMBL
	Connexin_CS	UniProtKB/TrEMBL
	Connexin_N	UniProtKB/TrEMBL
	Connexin_N_sf	UniProtKB/TrEMBL
NCBI Gene	Gjc1	ENTREZGENE
PANTHER	GAP JUNCTION GAMMA-1 PROTEIN	UniProtKB/TrEMBL
	PTHR11984	UniProtKB/TrEMBL
Pfam	Connexin	UniProtKB/TrEMBL
PRINTS	CONNEXIN	UniProtKB/TrEMBL
	CONNEXINA6	UniProtKB/TrEMBL
PROSITE	CONNEXINS_1	UniProtKB/TrEMBL
	CONNEXINS_2	UniProtKB/TrEMBL
SMART	CNX	UniProtKB/TrEMBL
	Connexin_CCC	UniProtKB/TrEMBL
UniProt	A0A654ICH8	ENTREZGENE, UniProtKB/TrEMBL
	I3MLG8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations