Cdkn1a (cyclin dependent kinase inhibitor 1A) - Rat Genome Database

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Gene: Cdkn1a (cyclin dependent kinase inhibitor 1A) Ictidomys tridecemlineatus
Analyze
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
RGD ID: 12523774
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to gamma radiation (ortholog); cellular response to heat (ortholog); PARTICIPATES IN G1/S transition pathway; Notch signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); Acute Experimental Pancreatitis (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleus (ortholog); PCNA-p21 complex (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase inhibitor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,717,260 - 22,725,182 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute Experimental Pancreatitis  (ISO)
Animal Mammary Neoplasms  (ISO)
Arsenic Poisoning  (ISO)
atrial fibrillation  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Barrett's esophagus  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholesteatoma of middle ear  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Congenital Cholesteatoma  (ISO)
Diabetic Nephropathies  (ISO)
ductal carcinoma in situ  (ISO)
Embryo Loss  (ISO)
Endometrial Neoplasms  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
facioscapulohumeral muscular dystrophy  (ISO)
Fuchs' endothelial dystrophy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
Habitual Abortions  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperoxia  (ISO)
Hyperplasia  (ISO)
Hypertrophy  (ISO)
Hypovolemia  (ISO)
Intestinal Neoplasms  (ISO)
inverted papilloma  (ISO)
kidney disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Lip Neoplasms  (ISO)
lipoid nephrosis  (ISO)
liver benign neoplasm  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
malignant mesothelioma  (ISO)
maxillary sinus squamous cell carcinoma  (ISO)
melanoma  (ISO)
Neoplasm Metastasis  (ISO)
ocular hypertension  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES  (ISO)
Salivary Gland Neoplasms  (ISO)
sarcoidosis  (ISO)
Sarcopenia  (ISO)
sebaceous gland neoplasm  (ISO)
Sepsis  (ISO)
serous cystadenocarcinoma  (ISO)
Skin Neoplasms  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to amino acid starvation  (IEA)
cellular response to cell-matrix adhesion  (IEA)
cellular response to gamma radiation  (IEA,ISO)
cellular response to heat  (ISO)
cellular response to ionizing radiation  (IEA)
cellular response to UV-B  (IEA)
cellular senescence  (IEA,ISO)
DNA damage response  (IEA,ISO)
epidermis development  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
heart development  (IEA)
import into nucleus  (IEA)
in utero embryonic development  (IEA,ISO)
intestinal epithelial cell maturation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
keratinocyte differentiation  (IEA,ISO)
keratinocyte proliferation  (IEA,ISO)
mitotic G1 DNA damage checkpoint signaling  (ISO)
mitotic G2 DNA damage checkpoint signaling  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle tissue regeneration  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cyclin-dependent protein kinase activity  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA biosynthetic process  (IEA)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA)
obsolete DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (ISO)
oncogene-induced cell senescence  (IEA,ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of programmed cell death  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of response to biotic stimulus  (ISO)
protein import into nucleus  (IEA,ISO)
Ras protein signal transduction  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell cycle G1/S phase transition  (IEA)
regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
regulation of DNA biosynthetic process  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of G2/M transition of mitotic cell cycle  (IEA)
regulation of mitotic cell cycle  (IEA,ISO)
replicative senescence  (IEA)
response to aldosterone  (ISO)
response to arsenic-containing substance  (ISO)
response to corticosterone  (ISO)
response to glucocorticoid  (ISO)
response to hyperoxia  (ISO)
response to toxic substance  (ISO)
response to UV  (IEA,ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction by p53 class mediator  (IEA)
tissue regeneration  (IEA)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cdkn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,717,260 - 22,725,182 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,676,460 - 36,687,397 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,644,240 - 36,655,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
T2T-CHM13v2.0636,497,108 - 36,508,013 (+)NCBIT2T-CHM13v2.0
Cdkn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,309,953 - 29,319,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,309,950 - 29,319,701 (+)EnsemblGRCm39 Ensembl
GRCm381729,090,979 - 29,100,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,090,976 - 29,100,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,227,931 - 29,237,667 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,821,439 - 28,828,386 (+)NCBIMGSCv36mm8
Celera1729,647,617 - 29,657,304 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.12NCBI
Cdkn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,150,820 - 7,161,373 (+)NCBIGRCr8
mRatBN7.2207,149,177 - 7,159,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,149,217 - 7,159,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,860,502 - 7,870,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,222,359 - 7,232,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,697,344 - 7,707,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,348,422 - 6,358,864 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,351,458 - 6,358,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,592,437 - 8,602,879 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,376,325 - 7,386,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,379,612 - 7,385,803 (+)NCBI
Celera208,699,290 - 8,709,718 (+)NCBICelera
Cytogenetic Map20p12NCBI
Cdkn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,254,309 - 6,261,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,254,638 - 6,261,278 (-)NCBIChiLan1.0ChiLan1.0
CDKN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,147,920 - 51,156,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,017,498 - 47,026,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,241,405 - 36,250,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,436,963 - 37,445,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,436,990 - 37,445,599 (+)Ensemblpanpan1.1panPan2
CDKN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,746,898 - 5,755,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,745,852 - 5,892,281 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,765,839 - 5,774,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,095,734 - 6,103,965 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1125,750,615 - 5,758,848 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,829,928 - 5,838,160 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,928,229 - 5,936,457 (+)NCBIUU_Cfam_GSD_1.0
CDKN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,354,672 - 32,363,761 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,354,776 - 32,363,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,258,037 - 37,267,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,445,668 - 35,454,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,445,223 - 35,454,342 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,625,094 - 36,634,245 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,108,874 - 21,115,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,109,074 - 21,115,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000027932   ⟹   ENSSTOP00000019336
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647622,717,260 - 22,725,182 (-)Ensembl
RefSeq Acc Id: XM_005318754   ⟹   XP_005318811
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBI
SpeTri2.0NW_00493647622,717,308 - 22,725,127 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040282580   ⟹   XP_040138514
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494641,235,185 - 41,242,922 (+)NCBI
RefSeq Acc Id: XM_040282581   ⟹   XP_040138515
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494641,235,060 - 41,242,922 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005318811 (Get FASTA)   NCBI Sequence Viewer  
  XP_040138514 (Get FASTA)   NCBI Sequence Viewer  
  XP_040138515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000019336.1
GenBank Protein KAG3289343 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005318811   ⟸   XM_005318754
- Peptide Label: isoform X1
- UniProtKB: I3N4P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040138515   ⟸   XM_040282581
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040138514   ⟸   XM_040282580
- Peptide Label: isoform X1
- UniProtKB: I3N4P0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000019336   ⟸   ENSSTOT00000027932
Protein Domains
Cyclin-dependent kinase inhibitor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021551 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027932.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/TrEMBL
InterPro CDI_dom UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/TrEMBL
  CDKN1A UniProtKB/TrEMBL
NCBI Gene Cdkn1a ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR46778 UniProtKB/TrEMBL
Pfam CDI UniProtKB/TrEMBL
UniProt I3N4P0 ENTREZGENE, UniProtKB/TrEMBL