Ulk2 (unc-51 like autophagy activating kinase 2) - Rat Genome Database

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Gene: Ulk2 (unc-51 like autophagy activating kinase 2) Ictidomys tridecemlineatus
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Symbol: Ulk2
Name: unc-51 like autophagy activating kinase 2
RGD ID: 12520941
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (inferred); AMP-activated protein kinase activity (inferred); ATP binding (inferred); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); collateral sprouting (ortholog); PARTICIPATES IN autophagy pathway; mTOR signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); malignant mesothelioma (ortholog); Meckel Syndrome 9 (ortholog); FOUND IN autophagosome (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase ULK2; unc-51 like autophagy activating kinase 2, transcript variant X1; unc-51 like autophagy activating kinase 2, transcript variant X2; unc-51 like autophagy activating kinase 2, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560258,649,694 - 58,760,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368211,051,053 - 1,162,735 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368211,051,247 - 1,162,500 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ulk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560258,649,694 - 58,760,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368211,051,053 - 1,162,735 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368211,051,247 - 1,162,500 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ULK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,770,830 - 19,867,936 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,770,829 - 19,867,936 (-)EnsemblGRCh38hg38GRCh38
GRCh371719,674,143 - 19,771,249 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,618,058 - 19,711,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 341719,618,057 - 19,711,822NCBI
Celera1717,087,510 - 17,184,615 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1719,053,022 - 19,150,095 (-)NCBIHuRef
CHM1_11719,683,011 - 19,780,062 (-)NCBICHM1_1
T2T-CHM13v2.01719,719,468 - 19,816,591 (-)NCBIT2T-CHM13v2.0
Ulk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,666,424 - 61,750,754 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,666,475 - 61,745,899 (-)EnsemblGRCm39 Ensembl
GRCm381161,775,598 - 61,855,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,775,649 - 61,855,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv371161,589,100 - 61,668,594 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,204,725 - 62,284,394 (-)NCBIMGSCv36mm8
MGSCv361161,591,855 - 61,670,812 (-)NCBIMGSCv36mm8
Celera1168,383,250 - 68,384,791 (-)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Ulk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,951,038 - 47,029,844 (-)NCBIGRCr8
mRatBN7.21046,451,578 - 46,530,462 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,454,030 - 46,530,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,154,771 - 51,233,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,645,302 - 50,724,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,148,711 - 46,227,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,050,079 - 48,129,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,050,803 - 48,129,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,842,925 - 47,922,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,931,165 - 48,009,986 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,945,282 - 48,023,093 (-)NCBI
Celera1045,699,296 - 45,777,617 (-)NCBICelera
Cytogenetic Map10q22NCBI
Ulk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467818,076 - 894,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955467818,975 - 894,103 (-)NCBIChiLan1.0ChiLan1.0
ULK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,761,346 - 54,860,712 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,573,111 - 59,672,009 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,262,168 - 31,362,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,409,345 - 36,506,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,409,312 - 36,507,786 (+)Ensemblpanpan1.1panPan2
ULK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,355,070 - 40,437,758 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,354,263 - 40,435,747 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,497,254 - 40,579,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,461,264 - 40,543,745 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,460,587 - 40,543,662 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,432,809 - 40,515,241 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,378,308 - 40,460,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,571,030 - 40,653,437 (+)NCBIUU_Cfam_GSD_1.0
ULK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,806,955 - 59,878,388 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11259,806,904 - 59,878,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,666,986 - 62,754,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ULK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11618,335,095 - 18,434,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1618,335,235 - 18,433,578 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660592,410,799 - 2,511,676 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000007186   ⟹   ENSSTOP00000006422
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049368211,051,053 - 1,162,735 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000035392   ⟹   ENSSTOP00000024729
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049368211,051,053 - 1,162,735 (+)Ensembl
RefSeq Acc Id: XM_005340826   ⟹   XP_005340883
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,649,694 - 58,760,958 (-)NCBI
SpeTri2.0NW_0049368211,051,247 - 1,162,500 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720552   ⟹   XP_021576227
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,651,617 - 58,760,486 (-)NCBI
SpeTri2.0NW_0049368211,051,300 - 1,160,582 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021720553   ⟹   XP_021576228
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,656,775 - 58,760,486 (-)NCBI
SpeTri2.0NW_0049368211,051,300 - 1,155,363 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040269584   ⟹   XP_040125518
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,651,617 - 58,760,486 (-)NCBI
RefSeq Acc Id: XM_040269585   ⟹   XP_040125519
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,655,924 - 58,760,486 (-)NCBI
RefSeq Acc Id: XM_040269586   ⟹   XP_040125520
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,651,617 - 58,757,647 (-)NCBI
RefSeq Acc Id: XM_040269587   ⟹   XP_040125521
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560258,651,617 - 58,757,637 (-)NCBI
RefSeq Acc Id: XP_005340883   ⟸   XM_005340826
- Peptide Label: isoform X2
- UniProtKB: I3M993 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021576227   ⟸   XM_021720552
- Peptide Label: isoform X1
- UniProtKB: A0A287CTX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021576228   ⟸   XM_021720553
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_040125518   ⟸   XM_040269584
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040125520   ⟸   XM_040269586
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040125521   ⟸   XM_040269587
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040125519   ⟸   XM_040269585
- Peptide Label: isoform X4
Ensembl Acc Id: ENSSTOP00000006422   ⟸   ENSSTOT00000007186
Ensembl Acc Id: ENSSTOP00000024729   ⟸   ENSSTOT00000035392
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007174 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007186.3 UniProtKB/TrEMBL
  ENSSTOT00000035392.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Atg1-like UniProtKB/TrEMBL
  ATG1-like_MIT2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_kinase_C UniProtKB/TrEMBL
NCBI Gene Ulk2 ENTREZGENE
PANTHER PTHR24348 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ULK2 UniProtKB/TrEMBL
Pfam ATG1-like_MIT2 UniProtKB/TrEMBL
  DUF3543 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CTX4 ENTREZGENE, UniProtKB/TrEMBL
  I3M993 ENTREZGENE, UniProtKB/TrEMBL