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Gene: Hax1 (HCLS1 associated protein X-1) Ictidomys tridecemlineatus

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Symbol:

Hax1

Name:

HCLS1 associated protein X-1

RGD ID:

12505577

Description:

ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN mitochondrion organization (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); dyschromatosis symmetrica hereditaria (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin-coated vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

HCLS1-associated protein X-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	24,931,036 - 24,933,940 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	3,961,441 - 3,964,322 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	3,961,433 - 3,964,322 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

dyschromatosis symmetrica hereditaria (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hereditary sensory neuropathy type 4 (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

neutropenia (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to cytokine stimulus (IEA)

granulocyte colony-stimulating factor signaling pathway (IEA)

mitochondrion organization (ISO)

negative regulation of apoptotic process (IEA)

positive regulation of granulocyte differentiation (IEA)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of actin filament organization (IEA)

regulation of actin filament polymerization (IEA)

Cellular Component

actin cytoskeleton (IEA)

apical plasma membrane (IEA,ISO)

clathrin-coated vesicle (IEA,ISO)

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IEA)

lamellipodium (IEA)

membrane (IEA)

mitochondrial intermembrane space (IEA)

mitochondrial matrix (IEA)

mitochondrial outer membrane (IEA)

mitochondrion (IEA)

nuclear membrane (IEA)

nucleus (IEA)

sarcoplasmic reticulum (IEA)

transcription regulator complex (IEA)

Molecular Function

interleukin-1 binding (IEA)

protein binding (ISO)

protein domain specific binding (ISO)

signaling adaptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hax1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	24,931,036 - 24,933,940 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	3,961,441 - 3,964,322 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	3,961,433 - 3,964,322 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HAX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	154,272,629 - 154,275,875 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	154,272,355 - 154,275,875 (+)	Ensembl			hg38	GRCh38
GRCh37	1	154,245,105 - 154,248,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	152,511,663 - 152,514,975 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	127,316,760 - 127,320,072 (+)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	125,608,714 - 125,612,284 (+)	NCBI		HuRef
CHM1_1	1	155,641,372 - 155,644,684 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	153,409,836 - 153,413,082 (+)	NCBI		T2T-CHM13v2.0

Hax1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	89,902,753 - 89,906,023 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	89,902,753 - 89,906,087 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	89,995,446 - 89,998,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	89,995,446 - 89,998,780 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	89,799,379 - 89,802,608 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	90,081,384 - 90,084,613 (-)	NCBI		MGSCv36	mm8
Celera	3	90,031,997 - 90,035,226 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	39.19	NCBI

Hax1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	177,731,918 - 177,735,670 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	177,731,921 - 177,735,390 (-)	Ensembl				GRCr8
mRatBN7.2	2	175,434,242 - 175,437,926 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	175,434,238 - 175,437,714 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	182,580,384 - 182,584,008 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	180,602,762 - 180,606,385 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	175,203,701 - 175,207,091 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	189,330,900 - 189,333,305 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	189,330,902 - 189,333,322 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	208,762,955 - 208,765,360 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	2	169,373,704 - 169,377,128 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Hax1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	816,793 - 819,667 (+)	Ensembl
ChiLan1.0	NW_004955545	816,789 - 819,667 (+)	NCBI	ChiLan1.0	ChiLan1.0

HAX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	95,558,149 - 95,561,448 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	95,293,380 - 95,296,608 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	129,627,564 - 129,630,920 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	133,241,077 - 133,244,431 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	133,241,077 - 133,244,431 (+)	Ensembl			panPan2	panpan1.1

HAX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	42,969,711 - 42,972,783 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	42,969,713 - 42,972,710 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	42,460,105 - 42,463,208 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	42,839,626 - 42,842,730 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	42,839,626 - 42,842,623 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	42,618,971 - 42,622,074 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	42,672,236 - 42,675,339 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	42,956,327 - 42,959,430 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

HAX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	95,467,632 - 95,470,290 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	95,467,629 - 95,470,972 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	104,384,708 - 104,387,371 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HAX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	9,537,544 - 9,545,214 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	9,537,525 - 9,545,299 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	8,899,738 - 8,903,169 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hax1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	3,039,256 - 3,042,362 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624885	3,039,711 - 3,042,702 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040287637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040287638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000014611 ⟹ ENSSTOP00000013090

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936580	3,961,441 - 3,964,322 (+)	Ensembl

RefSeq Acc Id:

XM_005331299 ⟹ XP_005331356

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	24,931,036 - 24,933,940 (+)	NCBI
SpeTri2.0	NW_004936580	3,961,433 - 3,964,322 (+)	NCBI

Sequence:

show sequence

GCCGCCTCAATTTTCGGCAGCGTAGTGCAGGCTTCCCTCTGGGGCGAATGGGCCGCGCAAGAGG
TCCCAAGGTTCGAGTCCCAGTGCGGGAATGAGCCTCTTTGACCTCTTCCGGGGCTTTTTCGGCT
TTTCTGGACCTCGGAGAGATCCCTTTTTTGGAGGGATGACTCGAGACGAAGATGAGGACGATGA
GGAAGAGGAAGAGGAAGGAGCCCCATGGAGCCGTGGGAACCGGAGGTTTGATGGTTCCCAGCAC
CCAGAGGAATTTGGCTTCAGCTTCAGCTTCAGCCCAGAAGAAGGGATGCGTTTCCAGGATAACT
TCGGCTTCGATGACCTCGTACGGGACTTCAATAGTATCTTCAGCGAGATGGGGGCCTGGACCTT
GCCTTCCCGCCCACCTGAGCTTCCAGGGCCTCAGTCGGAAGCACCTGGTGAGAGACTGCAGGAG
GGACAGACCCTTCGGGACTCAATGCTTAAGTACCCAGATAGTCACCAACCCAGGATCTTTGGTG
GGGTCTTGGAGAGTGATGCAAGAACTGAGTCCCCGAAACCAGCACCAGACTGGGGGTCCCAGAG
ACCTTTTCATAGGTTTGATGATATGTGGCCAGTGACTCCCCATCCTAGAGCCAGAGAAGACAAT
GATCTTGATTCCCAGGTTTCCCAGGAAGGTCTTGGCCCAGTTCTCCAGCCCCAGCCCAAATCCT
ATTTCAAGAGCATCTCTGTGACCAAGATCACTAAGCCAGATGGGATAGTGGAGGAGCGCAGGAC
TGTGGTGGACAGTGAGGGCCGGAGGGAGACCACAGTGACCCGTCAAGAACCAGAGAGCAGTCCT
AGATGTGATCCAGAATCACCAAGACCTCCGGCCCTGGATGATGCTTTTTCCATTCTGGATTTAT
TCCTAGGACGTTGGTTTCGGTCCCGGTAGCCTTGTTAATCTTAGGGGCCTTCAGGTCCTTTCTA
CTTCTCACTCATTGCCCACCATCATTAAGCTTAGCTTCTTCTGCCACCTCAGGGGCTTGGGTAT
GTGGAACAGTGATTTGGGGGTGTGTTAGTCTGCCACTCACCTAGACTGACCAATAAAACCTTTA
TTTATGCTA

hide sequence

RefSeq Acc Id:

XM_040287637 ⟹ XP_040143571

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	24,931,047 - 24,933,940 (+)	NCBI

RefSeq Acc Id:

XM_040287638 ⟹ XP_040143572

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	24,931,204 - 24,933,940 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005331356	(Get FASTA)	NCBI Sequence Viewer
	XP_040143571	(Get FASTA)	NCBI Sequence Viewer
	XP_040143572	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013090.3
GenBank Protein	KAG3281683	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005331356 ⟸ XM_005331299

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSLFDLFRGFFGFSGPRRDPFFGGMTRDEDEDDEEEEEEGAPWSRGNRRFDGSQHPEEFGFSFS
FSPEEGMRFQDNFGFDDLVRDFNSIFSEMGAWTLPSRPPELPGPQSEAPGERLQEGQTLRDSML
KYPDSHQPRIFGGVLESDARTESPKPAPDWGSQRPFHRFDDMWPVTPHPRAREDNDLDSQVSQE
GLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRRETTVTRQEPESSPRCDPESPRP
PALDDAFSILDLFLGRWFRSR

hide sequence

RefSeq Acc Id:	XP_040143571 ⟸ XM_040287637
- Peptide Label:	isoform X2
- UniProtKB:	I3MN90 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040143572 ⟸ XM_040287638
- Peptide Label:	isoform X2
- UniProtKB:	I3MN90 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000013090 ⟸ ENSSTOT00000014611

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014614	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014611.3	UniProtKB/TrEMBL
InterPro	HAX-1	UniProtKB/TrEMBL
NCBI Gene	Hax1	ENTREZGENE
PANTHER	HCLS1-ASSOCIATED PROTEIN X-1	UniProtKB/TrEMBL
	PTHR14938	UniProtKB/TrEMBL
PIRSF	HS1-associating_X-1	UniProtKB/TrEMBL
UniProt	I3MN90	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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