LOC101967362 (mediator of RNA polymerase II transcription subunit 6) - Rat Genome Database

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Gene: LOC101967362 (mediator of RNA polymerase II transcription subunit 6) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101967362 (Ensembl: ADAM21)
Name: mediator of RNA polymerase II transcription subunit 6 (Ensembl:ADAM metallopeptidase domain 21)
RGD ID: 12503543
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); protein ubiquitination (ortholog); somatic stem cell population maintenance (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; FOUND IN nucleus (ortholog); ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ADAM metallopeptidase domain 21; Adam21; disintegrin and metalloproteinase domain-containing protein 21; Med6; mediator complex subunit 6; mediator complex subunit 6, transcript variant X1; mediator complex subunit 6, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864031,850,117 - 31,972,073 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936488195,140 - 218,814 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493648897,118 - 99,286 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936488195,629 - 218,762 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101967362
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864031,850,117 - 31,972,073 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936488195,140 - 218,814 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493648897,118 - 99,286 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936488195,629 - 218,762 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381470,583,221 - 70,600,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1470,581,257 - 70,600,690 (-)EnsemblGRCh38hg38GRCh38
GRCh371471,049,938 - 71,067,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361470,120,710 - 70,137,137 (-)NCBINCBI36Build 36hg18NCBI36
Build 341470,120,709 - 70,137,137NCBI
Celera1451,114,912 - 51,131,341 (-)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1451,219,608 - 51,236,039 (-)NCBIHuRef
CHM1_11470,989,144 - 71,005,574 (-)NCBICHM1_1
T2T-CHM13v2.01464,789,242 - 64,806,677 (-)NCBIT2T-CHM13v2.0
Med6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,620,331 - 81,641,782 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,620,331 - 81,641,782 (-)EnsemblGRCm39 Ensembl
GRCm381281,573,557 - 81,595,008 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,573,557 - 81,595,008 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,674,551 - 82,695,945 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,492,412 - 82,513,806 (-)NCBIMGSCv36mm8
Celera1283,040,726 - 83,062,061 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.8NCBI
Med6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86107,001,664 - 107,015,130 (-)NCBIGRCr8
mRatBN7.26101,270,410 - 101,283,929 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6101,270,410 - 101,283,876 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6101,419,701 - 101,433,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,718,892 - 101,732,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06101,091,521 - 101,105,008 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06105,302,558 - 105,316,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6105,302,558 - 105,316,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06113,448,725 - 113,462,191 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46105,432,911 - 105,446,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16105,436,367 - 105,449,955 (-)NCBI
Celera699,104,393 - 99,117,857 (-)NCBICelera
Cytogenetic Map6q24NCBI
Med6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555234,550,348 - 4,558,806 (+)NCBIChiLan1.0ChiLan1.0
MED6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,702,358 - 71,719,495 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,918,876 - 70,936,008 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,171,280 - 51,189,026 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11470,040,797 - 70,058,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1470,038,686 - 70,058,469 (-)Ensemblpanpan1.1panPan2
MED6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1844,301,449 - 44,323,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl844,301,297 - 44,323,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,966,808 - 43,987,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,525,850 - 44,546,220 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl844,526,104 - 44,581,506 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1844,179,821 - 44,200,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0844,224,815 - 44,245,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,585,829 - 44,606,192 (-)NCBIUU_Cfam_GSD_1.0
MED6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl794,157,731 - 94,219,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1794,157,624 - 94,184,606 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27100,607,074 - 100,629,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12447,785,637 - 47,801,404 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2447,781,875 - 47,801,361 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605336,007,877 - 36,024,008 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473430,604,254 - 30,621,213 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473430,604,314 - 30,621,116 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000014084   ⟹   ENSSTOP00000012621
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936488195,632 - 218,767 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000026486   ⟹   ENSSTOP00000023706
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648897,118 - 99,286 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034764   ⟹   ENSSTOP00000025752
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936488195,140 - 214,270 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000036414   ⟹   ENSSTOP00000026512
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936488195,140 - 218,814 (-)Ensembl
RefSeq Acc Id: XM_005321188   ⟹   XP_005321245
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,850,120 - 31,873,338 (+)NCBI
SpeTri2.0NW_004936488195,629 - 218,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005321189   ⟹   XP_005321246
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,850,119 - 31,873,338 (+)NCBI
SpeTri2.0NW_004936488195,629 - 218,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356818   ⟹   XP_013212272
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,956,772 - 31,972,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040274295   ⟹   XP_040130229
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,850,117 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274296   ⟹   XP_040130230
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,850,189 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274297   ⟹   XP_040130231
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,860,002 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274298   ⟹   XP_040130232
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,860,831 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274299   ⟹   XP_040130233
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,956,772 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274300   ⟹   XP_040130234
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,952,502 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274301   ⟹   XP_040130235
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,956,771 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274302   ⟹   XP_040130236
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,956,771 - 31,972,073 (+)NCBI
RefSeq Acc Id: XM_040274303   ⟹   XP_040130237
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864031,956,771 - 31,972,073 (+)NCBI
RefSeq Acc Id: XP_005321246   ⟸   XM_005321189
- Peptide Label: isoform X6
- UniProtKB: I3MM91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005321245   ⟸   XM_005321188
- Peptide Label: isoform X5
- UniProtKB: A0A287CYX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040130229   ⟸   XM_040274295
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040130230   ⟸   XM_040274296
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040130231   ⟸   XM_040274297
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040130232   ⟸   XM_040274298
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040130234   ⟸   XM_040274300
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040130236   ⟸   XM_040274302
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040130237   ⟸   XM_040274303
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040130235   ⟸   XM_040274301
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040130233   ⟸   XM_040274299
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_013212272   ⟸   XM_013356818
- Peptide Label: isoform X4
- UniProtKB: I3NH59 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000026512   ⟸   ENSSTOT00000036414
Ensembl Acc Id: ENSSTOP00000025752   ⟸   ENSSTOT00000034764
Ensembl Acc Id: ENSSTOP00000023706   ⟸   ENSSTOT00000026486
Ensembl Acc Id: ENSSTOP00000012621   ⟸   ENSSTOT00000014084
Protein Domains
Disintegrin   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014084 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00000028832 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014084.3 UniProtKB/TrEMBL
  ENSSTOT00000026486.2 UniProtKB/TrEMBL
  ENSSTOT00000034764.1 UniProtKB/TrEMBL
  ENSSTOT00000036414.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.580 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Mediator_Med6 UniProtKB/TrEMBL
  Mediator_Med6_met/pln UniProtKB/TrEMBL
  Mediator_Med6_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene Med6 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21 UniProtKB/TrEMBL
  MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 6 UniProtKB/TrEMBL
  PTHR13104 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Med6 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PIRSF Mediator_MED6_meta/pln UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A287CWS7_ICTTR UniProtKB/TrEMBL
  A0A287CYX4 ENTREZGENE, UniProtKB/TrEMBL
  I3MM91 ENTREZGENE, UniProtKB/TrEMBL
  I3NH59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101967362  mediator of RNA polymerase II transcription subunit 6  Med6  mediator complex subunit 6  Symbol and/or name change 5135510 APPROVED
2021-03-25 Med6  mediator complex subunit 6  Adam21  ADAM metallopeptidase domain 21  Data merged from RGD:12586576 737654 PROVISIONAL