Nr1h2 (nuclear receptor subfamily 1 group H member 2) - Rat Genome Database

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Gene: Nr1h2 (nuclear receptor subfamily 1 group H member 2) Ictidomys tridecemlineatus
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Symbol: Nr1h2
Name: nuclear receptor subfamily 1 group H member 2
RGD ID: 12492066
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); nuclear retinoid X receptor binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN lipid metabolic process (ortholog); negative regulation of gene expression (ortholog); positive regulation of cholesterol efflux (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); cholestasis (ortholog); Colorectal Cancer 10 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); RNA polymerase II transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear receptor subfamily 1 group H member 2, transcript variant X1; nuclear receptor subfamily 1 group H member 2, transcript variant X2; oxysterols receptor LXR-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889223,101 - 229,990 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889223,137 - 229,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cholesterol homeostasis  (IEA)
intracellular receptor signaling pathway  (IEA)
lipid homeostasis  (IEA)
lipid metabolic process  (IEA,ISO)
negative regulation of cholesterol storage  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of lipid transport  (IEA)
negative regulation of pinocytosis  (IEA)
negative regulation of proteolysis  (IEA)
negative regulation of response to endoplasmic reticulum stress  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
phosphatidylcholine acyl-chain remodeling  (IEA)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of cholesterol transport  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of fatty acid biosynthetic process  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of high-density lipoprotein particle assembly  (IEA)
positive regulation of lipid storage  (IEA)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of pancreatic juice secretion  (IEA)
positive regulation of protein metabolic process  (IEA)
positive regulation of secretion of lysosomal enzymes  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of triglyceride biosynthetic process  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to nutrient levels  (ISO)
retinoic acid receptor signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nr1h2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889223,101 - 229,990 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889223,137 - 229,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1H2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,329,653 - 50,383,388 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,879,714 - 50,886,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36Build 36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
T2T-CHM13v2.01953,464,005 - 53,470,940 (+)NCBIT2T-CHM13v2.0
Nr1h2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,199,040 - 44,204,928 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,199,040 - 44,203,375 (-)EnsemblGRCm39 Ensembl
GRCm38744,549,616 - 44,553,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,549,616 - 44,553,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,805,002 - 51,809,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,417,674 - 44,421,965 (-)NCBIMGSCv36mm8
Celera739,999,761 - 40,004,052 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Nr1h2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,178,483 - 104,183,863 (-)NCBIGRCr8
mRatBN7.2195,041,967 - 95,047,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,427,372 - 100,432,752 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,900,016 - 108,905,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,190,437 - 102,195,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
Nr1h2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBIChiLan1.0ChiLan1.0
NR1H2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,442,021 - 56,448,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,363,472 - 58,370,113 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,340,077 - 47,346,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,243,124 - 56,250,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,243,124 - 56,250,024 (+)Ensemblpanpan1.1panPan2
NR1H2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,332,691 - 106,339,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,843,781 - 106,850,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBIUU_Cfam_GSD_1.0
NR1H2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,239,500 - 55,245,456 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,238,536 - 55,245,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,087,383 - 51,094,318 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR1H2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,438,428 - 43,445,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,437,950 - 43,446,063 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,425,677 - 23,432,503 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1h2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,132,904 - 4,140,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,136,052 - 4,141,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000011734   ⟹   ENSSTOP00000010529
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936889224,387 - 229,415 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000036709   ⟹   ENSSTOP00000028032
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936889223,101 - 229,990 (+)Ensembl
RefSeq Acc Id: XM_005341659   ⟹   XP_005341716
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBI
SpeTri2.0NW_004936889223,137 - 229,798 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005341716 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000010529.3
  ENSSTOP00000028032.1
GenBank Protein KAG3256567 (Get FASTA)   NCBI Sequence Viewer  
  KAG3256568 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005341716   ⟸   XM_005341659
- UniProtKB: I3MHW7 (UniProtKB/TrEMBL),   A0A287D3D1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000010529   ⟸   ENSSTOT00000011734
Ensembl Acc Id: ENSSTOP00000028032   ⟸   ENSSTOT00000036709
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011725 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011734.3 UniProtKB/TrEMBL
  ENSSTOT00000036709.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro Liver_X_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Nr1h2 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  OXYSTEROLS RECEPTOR LXR-BETA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS LIVERXRECPTR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A287D3D1 ENTREZGENE, UniProtKB/TrEMBL
  I3MHW7 ENTREZGENE, UniProtKB/TrEMBL