Fmr1<sup>em1Mzhe</sup> (FMRP translational regulator 1; CRISPR/Cas9 induced mutant1, Mzhe) - Rat Genome Database

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Gene: Fmr1em1Mzhe (FMRP translational regulator 1; CRISPR/Cas9 induced mutant1, Mzhe) Rattus norvegicus
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Symbol: Fmr1em1Mzhe
Name: FMRP translational regulator 1; CRISPR/Cas9 induced mutant1, Mzhe
RGD ID: 124715480
Description: CRISPR/Cas9 system was used to introduce deletions/mutations in exon 4 of rat Fmr1 gene of outbred Sprague-Dawley embryos. The resulting mutation a deletion of five amino acids and a G-A mutation in the Fmr1 gene. This genetic modification resulted in a frame-shift starting from the second Agenet-like 2 domain in Fmr1 protein.
ASSOCIATED WITH abnormal response to social novelty; abnormal temporal memory; enlarged testis; ASSOCIATED WITH fragile X syndrome
Type: allele  of Fmr1  
Previously known as: Fmr1^[em1Mzhe]
Is Marker For: Strains:   SD-Fmr1em1Mzhe  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Tian Y, etal., Front Mol Neurosci. 2017 Aug 28;10:269. doi: 10.3389/fnmol.2017.00269. eCollection 2017.

Genomics


Related Rat Strains
The following Strains have been annotated to Fmr1em1Mzhe


Expression


Sequence

Nucleotide Sequences


Additional Information