Vdr<sup>em2Thka</sup> (vitamin D receptor; CRISPR/Cas9 induced mutant 2, Thka) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Vdrem2Thka (vitamin D receptor; CRISPR/Cas9 induced mutant 2, Thka) Rattus norvegicus
Analyze
Symbol: Vdrem2Thka
Name: vitamin D receptor; CRISPR/Cas9 induced mutant 2, Thka
RGD ID: 124713550
Description: This mutation was created by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to disrupt the array near the arginine codon (CGC) at position 270 of the Vdr gene. This resulted in 1bp deletion and caused premature stop at p266 of the Vdr gene.
ASSOCIATED WITH abnormal cartilage morphology; abnormal skin appearance; abnormal trabecular bone morphology; ASSOCIATED WITH vitamin D-dependent rickets type 2A
Type: allele  of Vdr  
Previously known as: Vdr^[em2Thka]
Is Marker For: Strains:   W-Vdrem2Thka  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions. Nishikawa M, etal., Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.

Genomics


Related Rat Strains
The following Strains have been annotated to Vdrem2Thka
W-Vdrem2Thka    


Expression


Sequence

Nucleotide Sequences


Additional Information